Package: spatzie 1.13.0

Jennifer Hammelman

spatzie: Identification of enriched motif pairs from chromatin interaction data

Identifies motifs that are significantly co-enriched from enhancer-promoter interaction data. While enhancer-promoter annotation is commonly used to define groups of interaction anchors, spatzie also supports co-enrichment analysis between preprocessed interaction anchors. Supports BEDPE interaction data derived from genome-wide assays such as HiC, ChIA-PET, and HiChIP. Can also be used to look for differentially enriched motif pairs between two interaction experiments.

Authors:Jennifer Hammelman [aut, cre, cph], Konstantin Krismer [aut], David Gifford [ths, cph]

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spatzie.pdf |spatzie.html
spatzie/json (API)
NEWS

# Install 'spatzie' in R:
install.packages('spatzie', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:

On BioConductor:spatzie-1.13.0(bioc 3.21)spatzie-1.12.0(bioc 3.20)

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

dna3dstructuregeneregulationpeakdetectionepigeneticsfunctionalgenomicsclassificationhictranscription

4.30 score 5 scripts 128 downloads 8 exports 174 dependencies

Last updated 23 days agofrom:c97feec465. Checks:OK: 1 WARNING: 6. Indexed: yes.

TargetResultDate
Doc / VignettesOKNov 14 2024
R-4.5-winWARNINGNov 14 2024
R-4.5-linuxWARNINGNov 14 2024
R-4.4-winWARNINGNov 14 2024
R-4.4-macWARNINGNov 14 2024
R-4.3-winWARNINGNov 14 2024
R-4.3-macWARNINGNov 14 2024

Exports:anchor_pair_enrichcompare_motif_pairsfilter_motifsfilter_pair_motifsfind_ep_coenrichmentget_specific_interactionsplot_motif_occurrencescan_motifs

Dependencies:abindannotateAnnotationDbiAnnotationFilteraskpassbackportsbase64encBHBiobaseBiocFileCacheBiocGenericsBiocIOBiocParallelbiomaRtBiostringsbiovizBasebitbit64bitopsblobBSgenomebslibcachemcaToolscheckmateclicliprclusterCNErcodetoolscolorspacecpp11crayoncurldata.tableDBIdbplyrDelayedArraydeldirdichromatdigestDirichletMultinomialdplyrensembldbevaluatefansifarverfastmapfilelockfontawesomeforeignformatRFormulafsfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicFeaturesGenomicInteractionsGenomicRangesggplot2glueGO.dbgridExtragtablegtoolsGvizhighrHmischmshtmlTablehtmltoolshtmlwidgetshttrhttr2igraphInteractionSetinterpIRangesisobandjpegjquerylibjsonliteKEGGRESTknitrlabelinglambda.rlatticelatticeExtralazyevallifecyclemagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemotifmatchrmunsellnlmennetopensslpillarpkgconfigplogrplyrpngpoweRlawpracmaprettyunitsprogressProtGenericspurrrpwalignR.methodsS3R.ooR.utilsR6rappdirsRColorBrewerRcppRcppArmadilloRcppEigenRCurlreadrreshape2restfulrRhtslibrjsonrlangrmarkdownrpartRsamtoolsRSQLiterstudioapirtracklayerS4ArraysS4VectorssassscalesseqLogosnowSparseArraystringistringrSummarizedExperimentsysTFBSToolsTFMPvaluetibbletidyrtidyselecttinytextzdbUCSC.utilsutf8VariantAnnotationvctrsviridisviridisLitevroomwithrxfunXMLxml2xtableXVectoryamlzlibbioc

YY1 ChIA-PET motif analysis (single call)

Rendered fromsingle-call.Rmdusingknitr::rmarkdownon Nov 14 2024.

Last update: 2022-02-03
Started: 2021-05-20

YY1 ChIA-PET motif analysis (step-by-step)

Rendered fromindividual-steps.Rmdusingknitr::rmarkdownon Nov 14 2024.

Last update: 2022-02-03
Started: 2021-05-20

Readme and manuals

Help Manual

Help pageTopics
Determine enriched motifs in anchorsanchor_pair_enrich
spatzie count correlation data setanchor_pair_example_count
spatzie match association data setanchor_pair_example_match
spatzie score correlation data setanchor_pair_example_score
Compare pairs of motifs between two interaction datasetscompare_motif_pairs
compare_motif_pairs examplecompare_pairs_example
Filter motifs based on occurrence within interaction datafilter_motifs
Filter significant motif interactionsfilter_pair_motifs
spatzie score correlation filtered data setfilter_pairs_example
Find co-enriched motif pairs in enhancer-promoter interactionsfind_ep_coenrichment
Get interactions that contain a specific motif pairget_specific_interactions
K562 Enhancer - Promoter Interactions Data Setint_data_k562
MSLCL Enhancer - Promoter Interactions Data Setint_data_mslcl
Mouse YY1 Enhancer - Promoter Interactions Data Setint_data_yy1
Mouse YY1 Enhancer - Promoter Interactions Data Setinteractions_yy1
Mouse YY1 Enhancer - Promoter Interactions Data Set - YY1 enhancersinteractions_yy1_enhancer
Mouse YY1 Enhancer - Promoter Interactions Data Set - YY1 enhancers/promotersinteractions_yy1_ep
Mouse YY1 Enhancer - Promoter Interactions Data Set - YY1 promotersinteractions_yy1_promoter
Plot motif occurrenceplot_motif_occurrence
Interactions scanned for motifs - interactionData objectscan_interactions_example
Interactions with motifs filtered for significance - interactionData objectscan_interactions_example_filtered
Scans interaction file for motif instancesscan_motifs
spatziespatzie