Package: ctdR 0.99.11
ctdR: Enrichment Analysis of Chemical-Gene Interactions from the Comparative Toxicogenomics Database
Identifies chemicals significantly associated with a set of genes using data from the Comparative Toxicogenomics Database (CTD, <https://ctdbase.org>). Supports four enrichment methods through a unified interface: Over-Representation Analysis (ORA) via a hypergeometric test on stats::phyper(), Gene Set Enrichment Analysis (GSEA) via 'fgsea', the competitive gene-set test CAMERA via 'limma', and per-sample Gene Set Variation Analysis (GSVA) via 'GSVA'. Users download the CTD chemical-gene interactions file once, import it with import_CTD(), and then run enrichment_CTD() on either a gene list (ORA, GSEA) or an expression matrix (CAMERA, GSVA). This package does not bundle or redistribute CTD data. Users must download the required data files directly from <https://ctdbase.org> and comply with the CTD data licensing terms (see <https://ctdbase.org/about/legal.jsp>).
Authors:
ctdR_0.99.11.tar.gz
ctdR_0.99.11.zip(r-4.7-any)ctdR_0.99.11.zip(r-4.6-any)ctdR_0.99.11.zip(r-4.5-any)
ctdR_0.99.11.tgz(r-4.6-any)ctdR_0.99.11.tgz(r-4.5-any)
ctdR_0.99.11.tar.gz(r-4.7-any)ctdR_0.99.11.tar.gz(r-4.6-any)
ctdR_0.99.11.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
ctdR/json (API)
| # Install 'ctdR' in R: |
| install.packages('ctdR', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/drake69/ctdr/issues
Pkgdown/docs site:https://luigicorsaro.com
On BioConductor:ctdR-0.99.11(bioc 3.24)
genesetenrichmentpathwaysannotationgeneexpressiondataimport
Last updated from:57961d56c8. Checks:1 NOTE, 9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| bioc-checks | NOTE | 179 | ||
| linux-devel | OK | 374 | ||
| source / vignettes | OK | 289 | ||
| linux-release | OK | 379 | ||
| macos-release | OK | 286 | ||
| macos-oldrel | OK | 279 | ||
| windows-devel | OK | 204 | ||
| windows-release | OK | 289 | ||
| windows-oldrel | OK | 268 | ||
| wasm-release | OK | 173 |
Exports:as_genesets_CTDctd_cachectd_provenanceCTDFileenrichment_CTDimportimport_CTDplot_CTD
Dependencies:abindannotateAnnotationDbiaskpassBHBiobaseBiocBaseUtilsBiocFileCacheBiocGenericsBiocIObiocmakeBiocParallelBiostringsbitbit64blobcachemclicliprcodetoolscowplotcpp11crayoncurldata.tableDBIdbplyrDelayedArrayDelayedMatrixStatsdir.expirydplyrfarverfastmapfastmatchfgseafilelockformatRfutile.loggerfutile.optionsgenericsGenomicRangesggplot2gluegraphGSEABaseGSVAgtableh5mreadHDF5Arrayhmshttrhttr2IRangesisobandjsonliteKEGGRESTlabelinglambda.rlatticelifecyclelimmamagickmagrittrMatrixMatrixGenericsmatrixStatsmemoisememusemimeopensslorg.Hs.eg.dbpillarpkgconfigpngprettyunitsprogresspurrrR6RColorBrewerRcppreadrrhdf5rhdf5filtersRhdf5librjsonrlangRSQLiteS4ArraysS4VectorsS7scalesSeqinfoSingleCellExperimentsnowSparseArraysparseMatrixStatsSpatialExperimentstatmodstringistringrSummarizedExperimentsystibbletidyrtidyselecttzdbutf8vctrsviridisLitevroomwithrXMLxtableXVector
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| ctdR: Enrichment Analysis of Chemical-Gene Interactions from CTD | ctdR-package ctdR |
| Export CTD Gene Sets for Existing Enrichment Engines | as_genesets_CTD |
| Retrieve Cached CTD Data | ctd_cache |
| Provenance of the CTD data an analysis ran on | ctd_provenance print.ctd_provenance |
| CTD Chemical-Gene Interactions File | .CTDFile CTDFile CTDFile-class import,CTDFile,ANY,ANY-method |
| Chemical Enrichment Analysis Using CTD | enrichment_CTD |
| Import CTD Chemical-Gene Interaction Data | import_CTD |
| Plot Chemical Enrichment Results | plot_CTD |
