Package: Repitools 1.53.0
Repitools: Epigenomic tools
Tools for the analysis of enrichment-based epigenomic data. Features include summarization and visualization of epigenomic data across promoters according to gene expression context, finding regions of differential methylation/binding, BayMeth for quantifying methylation etc.
Authors:
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Repitools.pdf |Repitools.html✨
Repitools/json (API)
# Install 'Repitools' in R: |
install.packages('Repitools', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org')) |
- chr21genes - Positions of Genes on Human Chromosome 21
On BioConductor:Repitools-1.53.0(bioc 3.21)Repitools-1.52.0(bioc 3.20)
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
dnamethylationgeneexpressionmethylseq
Last updated 5 months agofrom:b707049a0a. Checks:1 OK, 11 WARNING. Indexed: yes.
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Exports:abcdDNAabsoluteCNAdjustedCopyEstimateannoDF2GRannoGR2DFannotationBlocksCountsannotationBlocksLookupannotationCountsannotationLookupBAM2GRangesBAM2GRangesListBasic_StatisticsBayMethListbinPlotsblocksblocksStatscheckProbesChromaBlockschromosomeCNplotsClusteredScoresListclusterPlotsclusterscontrolcontrol<-CopyEstimatecpgBoxplotscpgDenscpgDens<-cpgDensityCalccpgDensityPlotcutoffdetermineOffsetempBayesenrichmentCalcenrichmentPlotFDRTablefeatureBlocksfeatureScoresfindClustersfOffsetfOffset<-GCadjustCopyGCAdjustParamsGCbiasPlotsgcContentCalcgenomeBlocksgenQCgetSampleOffsetshyperg2F1_vecloadPairFileloadSampleDirectorymakeWindowLookupTablemappabilityCalcmaskEmpBayesmaskEmpBayes<-maskOutmergeReplicatesmethEstmethEst<-methylEstMismatchesMismatchTablemultiHeatmapncontrolnsampleInterestOverrepresented_sequencesPer_base_GC_contentPer_base_N_contentPer_base_sequence_contentPer_base_sequence_qualityPer_sequence_GC_contentPer_sequence_quality_scoresplotClustersplotQdnaByCNpriorTabpriorTab<-processNDFprofilePlotsQdnaDatareadFastQCregionsregionStatsrelativeCNsampleInterestsampleInterest<-Sequence_Duplication_LevelsSequence_Length_DistributionsequenceCalcsetCNVOffsetsshowsubsetRowssummarizeScorestableswindows<-writeWig
Dependencies:abindaskpassBHBiobaseBiocGenericsBiocIOBiocParallelBiostringsbitopsBSgenomecaToolsclustercodetoolscpp11crayoncurlDelayedArrayDNAcopyedgeRformatRfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicRangesgplotsgsmoothrgtoolshttrIRangesjsonliteKernSmoothlambda.rlatticelimmalocfitMASSMatrixMatrixGenericsmatrixStatsmimeopensslR6RCurlrestfulrRhtslibrjsonRsamtoolsRsolnprtracklayerS4ArraysS4VectorssnowSparseArraystatmodSummarizedExperimentsystruncnormUCSC.utilsXMLXVectoryaml
Citation
Please cite the Bioinformatics paper for the software itself and the other papers for the various original statistical methods implemented in Repitools.
Statham AL, Strbenac D, Coolen MW, Stirzaker C, Clark SJ, Robinson MD. (2010). Repitools: an R package for the analysis of enrichment-based epigenomic data, Bioinformatics 26(13), 1662-3
Robinson MD, Strbenac D, Stirzaker C, Statham AL, Song J, Speed TP, Clark SJ (2012). Copy-number-aware differential analysis of quantitative DNA sequencing data. Genome Research 22(12):2489-96.
Riebler A, Menigatti M, Song JZ, Statham AL, Stirzaker C, Mahmud N, Mein CA, Clark SJ, Robinson MD (2014). BayMeth: Improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach, Genome Biol. 15(2):R35.
Corresponding BibTeX entries:
@Article{, title = {Repitools: an R package for the analysis of enrichment-based epigenomic data}, author = {Statham AL and Strbenac D and Coolen MW and Stirzaker C and Clark SJ and Robinson MD}, journal = {Bioinformatics}, volume = {26}, pages = {1659}, year = {2010}, }
@Article{, title = {Copy-number-aware differential analysis of quantitative DNA sequencing data}, author = {Robinson MD and Strbenac D and Stirzaker C and Statham AL and Song J and Speed TP and Clark SJ}, journal = {Genome Research}, volume = {22}, pages = {2393}, year = {2012}, }
@Article{, title = {BayMeth: Improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach}, author = {Riebler A and Menigatti M and Song JZ and Statham AL and Stirzaker C and Mahmud N and Mein CA and Clark SJ and Robinson MD}, journal = {Genome Biology}, year = {2014}, volume = {15}, pages = {R35}, }
Readme and manuals
Help Manual
Help page | Topics |
---|---|
A wrapper for fitting the offset-adjusted ABCD-DNA GLM | abcdDNA |
Calculate and Segment Absolute Copy Number from Sequencing Counts | absoluteCN absoluteCN,data.frame,matrix,GCAdjustParams-method absoluteCN,GRanges,matrix,GCAdjustParams-method |
Container for results of GC adjusted copy number estimation. | AdjustedCopyEstimate AdjustedCopyEstimate,numeric,GRanges,numeric,numeric,matrix,list,matrix,character-method AdjustedCopyEstimate-class show,AdjustedCopyEstimate-method |
Placeholder For AffymetrixCdfFile Documentation | AffymetrixCdfFile AffymetrixCdfFile-class |
Placeholder For AffymetrixCelSet Documentation | AffymetrixCelSet AffymetrixCelSet-class |
Convert a 'data.frame' to a 'GRanges'. | annoDF2GR annoDF2GR,data.frame-method |
Convert an annotated 'GRanges' to a 'data.frame'. | annoGR2DF annoGR2DF,GRanges-method |
Counts the number of sequencing reads within supplied genomic blocks. | annotationBlocksCounts annotationBlocksCounts,ANY,data.frame-method annotationBlocksCounts,character,GRanges-method annotationBlocksCounts,GRanges,GRanges-method annotationBlocksCounts,GRangesList,GRanges-method |
Forms a mapping between probe locations and chromosomal blocks (regions). | annotationBlocksLookup annotationBlocksLookup,data.frame,data.frame-method annotationBlocksLookup,data.frame,GRanges-method |
Counts the number of sequencing reads surrounding supplied annotations | annotationCounts annotationCounts,ANY,data.frame-method annotationCounts,ANY,GRanges-method |
Forms a mapping between probes on a tiling array and windows surrounding the TSSs of genes. | annotationLookup annotationLookup,data.frame,data.frame-method annotationLookup,data.frame,GRanges-method |
Read in a (list of) BAM file(s) into a GRanges(List) object. | BAM2GRanges BAM2GRanges,character-method BAM2GRangesList BAM2GRangesList,character-method |
Class '"BayMethList"' | BayMethList BayMethList,GRanges,matrix,matrix,numeric-method BayMethList-class control control,BayMethList-method control<- control<-,BayMethList-method cpgDens cpgDens,BayMethList-method cpgDens<- cpgDens<-,BayMethList-method fOffset fOffset,BayMethList-method fOffset<- fOffset<-,BayMethList-method length length,BayMethList-method maskEmpBayes maskEmpBayes,BayMethList-method maskEmpBayes<- maskEmpBayes<-,BayMethList-method methEst methEst,BayMethList-method methEst<- methEst<-,BayMethList-method ncontrol ncontrol,BayMethList-method nsampleInterest nsampleInterest,BayMethList-method priorTab priorTab,BayMethList-method priorTab<- priorTab<-,BayMethList-method sampleInterest sampleInterest,BayMethList-method sampleInterest<- sampleInterest<-,BayMethList-method show,BayMethList-method windows windows,BayMethList-method windows<- windows<-,BayMethList-method [,BayMethList,ANY,missing,ANY-method |
Create line plots of averaged signal across a promoter | binPlots binPlots,ScoresList-method |
Calculate statistics for regions in the genome | blocksStats blocksStats,ANY,data.frame-method blocksStats,ANY,GRanges-method |
Check Probe Specificity for Some Regions | checkProbes checkProbes,data.frame,data.frame-method checkProbes,GRanges,GRanges-method |
Positions of Genes on Human Chromosome 21 | chr21genes |
A function to find areas of enrichment in sequencing data | ChromaBlocks ChromaBlocks,GRangesList,GRangesList-method |
ChromaResults class | blocks blocks,ChromaResults-method ChromaResults ChromaResults-class class:ChromaResults cutoff cutoff,ChromaResults-method FDRTable FDRTable,ChromaResults-method regions regions,ChromaResults-method show,ChromaResults-method |
Plot copy number by chromosome | chromosomeCNplots chromosomeCNplots,AdjustedCopyEstimate-method chromosomeCNplots,CopyEstimate-method |
Container for coverage matrices with clustering results. | ClusteredScoresList ClusteredScoresList,ScoresList-method ClusteredScoresList-class clusters clusters,ClusteredScoresList-method show,ClusteredScoresList-method subsetRows,ClusteredScoresList-method [,ClusteredScoresList,ANY,missing,ANY-method |
Visualisation of tables of feature coverages. | clusterPlots clusterPlots,ClusteredScoresList-method clusterPlots,ScoresList-method |
Container for results of fold change copy number estimation. | CopyEstimate CopyEstimate,GRanges,matrix,GRangesList,character-method CopyEstimate-class show,CopyEstimate-method |
Boxplots of intensity, binned by Cpg Density | cpgBoxplots cpgBoxplots,AffymetrixCelSet-method cpgBoxplots,matrix-method |
Calculate CpG Density in a Window | cpgDensityCalc cpgDensityCalc,data.frame,BSgenome-method cpgDensityCalc,GRanges,BSgenome-method cpgDensityCalc,GRangesList,BSgenome-method |
Plot the distribution of sequencing reads CpG densities. | cpgDensityPlot cpgDensityPlot,GRangesList-method |
Function to determine the normalising offset f that accounts for the relative sequencing depth. | determineOffset |
Function to calculate prior parameters using empirical Bayes. | empBayes |
Calculate sequencing enrichment | enrichmentCalc enrichmentCalc,GRanges-method enrichmentCalc,GRangesList-method |
Plot the distribution of sequencing enrichment. | enrichmentPlot enrichmentPlot,GRangesList-method |
Vector of expression differences | expr |
FastQC and associated classes | Basic_Statistics Basic_Statistics,FastQC-method Basic_Statistics,SequenceQC-method Basic_Statistics,SequenceQCSet-method class:FastQC class:SequenceQC class:SequenceQCSet FastQC-class Mismatches Mismatches,SequenceQC-method Mismatches,SequenceQCSet-method MismatchTable MismatchTable,SequenceQC-method MismatchTable,SequenceQCSet-method Overrepresented_sequences Overrepresented_sequences,FastQC-method Overrepresented_sequences,SequenceQC-method Overrepresented_sequences,SequenceQCSet-method Per_base_GC_content Per_base_GC_content,FastQC-method Per_base_GC_content,SequenceQC-method Per_base_GC_content,SequenceQCSet-method Per_base_N_content Per_base_N_content,FastQC-method Per_base_N_content,SequenceQC-method Per_base_N_content,SequenceQCSet-method Per_base_sequence_content Per_base_sequence_content,FastQC-method Per_base_sequence_content,SequenceQC-method Per_base_sequence_content,SequenceQCSet-method Per_base_sequence_quality Per_base_sequence_quality,FastQC-method Per_base_sequence_quality,SequenceQC-method Per_base_sequence_quality,SequenceQCSet-method Per_sequence_GC_content Per_sequence_GC_content,FastQC-method Per_sequence_GC_content,SequenceQC-method Per_sequence_GC_content,SequenceQCSet-method Per_sequence_quality_scores Per_sequence_quality_scores,FastQC-method Per_sequence_quality_scores,SequenceQC-method Per_sequence_quality_scores,SequenceQCSet-method readFastQC SequenceQC-class SequenceQCSet SequenceQCSet-class Sequence_Duplication_Levels Sequence_Duplication_Levels,FastQC-method Sequence_Duplication_Levels,SequenceQC-method Sequence_Duplication_Levels,SequenceQCSet-method Sequence_Length_Distribution Sequence_Length_Distribution,FastQC-method Sequence_Length_Distribution,SequenceQC-method Sequence_Length_Distribution,SequenceQCSet-method show,FastQC-method show,SequenceQC-method show,SequenceQCSet-method [,SequenceQCSet,ANY,missing,ANY-method |
Make windows for distances around a reference point. | featureBlocks featureBlocks,data.frame-method featureBlocks,GRanges-method |
Get scores at regular sample points around genomic features. | featureScores featureScores,ANY,data.frame-method featureScores,ANY,GRanges-method |
Find Clusters Epigenetically Modified Genes | findClusters |
Calculate Absolute Copy Number from Sequencing Counts | GCadjustCopy GCadjustCopy,data.frame,matrix,GCAdjustParams-method GCadjustCopy,GRanges,matrix,GCAdjustParams-method |
Container for parameters for mappability and GC content adjusted absolute copy number estimation. | GCAdjustParams GCAdjustParams,BSgenome,MappabilitySource-method GCAdjustParams-class |
Plot GC content vs. Read Counts Before Normalising, and GC content vs. Copy Estimates After Normalising. | GCbiasPlots GCbiasPlots,AdjustedCopyEstimate-method |
Calculate The gcContent of a Region | gcContentCalc gcContentCalc,data.frame,BSgenome-method gcContentCalc,GRanges,BSgenome-method |
Creates bins across a genome. | genomeBlocks genomeBlocks,BSgenome-method genomeBlocks,numeric-method |
Plot Quality Checking Information for Sequencing Data | genQC genQC,character-method genQC,SequenceQCSet-method |
Translate Affymetrix probe information in a table. | getProbePositionsDf getProbePositionsDf,AffymetrixCdfFile-method |
Calculates the sample-specific offsets, using the neutral state | getSampleOffsets |
Masking files for hg19 | hcRegions |
Gaussian hypergeometric function for vectorial arguments | hyperg2F1_vec |
A routine to read Nimblegen tiling array intensities | loadPairFile |
A routine to read Nimblegen tiling array intensities | loadSampleDirectory |
Using the output of 'annotationLookup', create a tabular storage of the indices | makeWindowLookupTable |
Calculate The Mappability of a Region | mappabilityCalc mappabilityCalc,data.frame,MappabilitySource-method mappabilityCalc,GRanges,MappabilitySource-method |
Superclass for datatypes that can refer to genome mappability data. | MappabilitySource MappabilitySource-class |
Function to mask suspicious regions. | maskOut |
Merge GRanges that are of replicate experiments. | mergeReplicates mergeReplicates,GRangesList-method |
Function to derive regional methylation estimates. | methylEst |
Superfigure plots | multiHeatmap |
Plot Scores of Cluster Regions | plotClusters plotClusters,data.frame-method plotClusters,GRanges-method |
Plotting the response of qDNA-seq data by CNV | plotQdnaByCN |
Reads in a Nimblegen microarray design file (NDF) | processNDF |
Create line plots of averaged signal across a promoter for gene sets, compared to random sampling. | profilePlots profilePlots,ScoresList-method |
A container for quantitative DNA sequencing data for ABCD-DNA analyses | class:QdnaData QdnaData QdnaData-class show,QdnaData-method |
Find Regions of significance in microarray data | class:RegionStats regionStats regionStats,AffymetrixCelSet-method regionStats,matrix-method RegionStats-class show,RegionStats-method |
Calculate and Segment Relative Copy Number From Sequencing Counts | relativeCN relativeCN,data.frame,matrix-method relativeCN,GRanges,matrix-method |
Short Reads from Cancer and Normal | samplesList |
Container for 'featureScores()' output. | length,ScoresList-method names,ScoresList-method names<-,ScoresList-method ScoresList ScoresList-class show,ScoresList-method subsetRows subsetRows,ScoresList-method tables tables,ScoresList-method [,ScoresList,ANY,missing,ANY-method |
Find occurences of a DNA pattern | sequenceCalc sequenceCalc,data.frame,BSgenome-method sequenceCalc,GRanges,BSgenome-method |
Set the CNVOffsets of a 'QdnaData' object | setCNVOffsets |
Subtract scores of different samples. | summarizeScores summarizeScores,ScoresList,matrix-method |
Writes sequencing data out into wiggle files | writeWig writeWig,AffymetrixCelSet-method writeWig,GRangesList-method |