Package: Repitools 1.53.0

Mark Robinson

Repitools: Epigenomic tools

Tools for the analysis of enrichment-based epigenomic data. Features include summarization and visualization of epigenomic data across promoters according to gene expression context, finding regions of differential methylation/binding, BayMeth for quantifying methylation etc.

Authors:Mark Robinson <[email protected]>, Dario Strbenac <[email protected]>, Aaron Statham <[email protected]>, Andrea Riebler <[email protected]>

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# Install 'Repitools' in R:
install.packages('Repitools', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • chr21genes - Positions of Genes on Human Chromosome 21

On BioConductor:Repitools-1.53.0(bioc 3.21)Repitools-1.52.0(bioc 3.20)

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

dnamethylationgeneexpressionmethylseq

5.90 score 263 scripts 525 downloads 14 mentions 95 exports 65 dependencies

Last updated 2 months agofrom:b707049a0a. Checks:OK: 1 WARNING: 8. Indexed: yes.

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Exports:abcdDNAabsoluteCNAdjustedCopyEstimateannoDF2GRannoGR2DFannotationBlocksCountsannotationBlocksLookupannotationCountsannotationLookupBAM2GRangesBAM2GRangesListBasic_StatisticsBayMethListbinPlotsblocksblocksStatscheckProbesChromaBlockschromosomeCNplotsClusteredScoresListclusterPlotsclusterscontrolcontrol<-CopyEstimatecpgBoxplotscpgDenscpgDens<-cpgDensityCalccpgDensityPlotcutoffdetermineOffsetempBayesenrichmentCalcenrichmentPlotFDRTablefeatureBlocksfeatureScoresfindClustersfOffsetfOffset<-GCadjustCopyGCAdjustParamsGCbiasPlotsgcContentCalcgenomeBlocksgenQCgetSampleOffsetshyperg2F1_vecloadPairFileloadSampleDirectorymakeWindowLookupTablemappabilityCalcmaskEmpBayesmaskEmpBayes<-maskOutmergeReplicatesmethEstmethEst<-methylEstMismatchesMismatchTablemultiHeatmapncontrolnsampleInterestOverrepresented_sequencesPer_base_GC_contentPer_base_N_contentPer_base_sequence_contentPer_base_sequence_qualityPer_sequence_GC_contentPer_sequence_quality_scoresplotClustersplotQdnaByCNpriorTabpriorTab<-processNDFprofilePlotsQdnaDatareadFastQCregionsregionStatsrelativeCNsampleInterestsampleInterest<-Sequence_Duplication_LevelsSequence_Length_DistributionsequenceCalcsetCNVOffsetsshowsubsetRowssummarizeScorestableswindows<-writeWig

Dependencies:abindaskpassBHBiobaseBiocGenericsBiocIOBiocParallelBiostringsbitopsBSgenomecaToolsclustercodetoolscpp11crayoncurlDelayedArrayDNAcopyedgeRformatRfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicRangesgplotsgsmoothrgtoolshttrIRangesjsonliteKernSmoothlambda.rlatticelimmalocfitMASSMatrixMatrixGenericsmatrixStatsmimeopensslR6RCurlrestfulrRhtslibrjsonRsamtoolsRsolnprtracklayerS4ArraysS4VectorssnowSparseArraystatmodSummarizedExperimentsystruncnormUCSC.utilsXMLXVectoryamlzlibbioc

Using Repitools for Epigenomic Sequencing Data

Rendered fromRepitools_vignette.Rnwusingutils::Sweaveon Dec 01 2024.

Last update: 2013-11-01
Started: 2013-11-01

Readme and manuals

Help Manual

Help pageTopics
A wrapper for fitting the offset-adjusted ABCD-DNA GLMabcdDNA
Calculate and Segment Absolute Copy Number from Sequencing CountsabsoluteCN absoluteCN,data.frame,matrix,GCAdjustParams-method absoluteCN,GRanges,matrix,GCAdjustParams-method
Container for results of GC adjusted copy number estimation.AdjustedCopyEstimate AdjustedCopyEstimate,numeric,GRanges,numeric,numeric,matrix,list,matrix,character-method AdjustedCopyEstimate-class show,AdjustedCopyEstimate-method
Placeholder For AffymetrixCdfFile DocumentationAffymetrixCdfFile AffymetrixCdfFile-class
Placeholder For AffymetrixCelSet DocumentationAffymetrixCelSet AffymetrixCelSet-class
Convert a 'data.frame' to a 'GRanges'.annoDF2GR annoDF2GR,data.frame-method
Convert an annotated 'GRanges' to a 'data.frame'.annoGR2DF annoGR2DF,GRanges-method
Counts the number of sequencing reads within supplied genomic blocks.annotationBlocksCounts annotationBlocksCounts,ANY,data.frame-method annotationBlocksCounts,character,GRanges-method annotationBlocksCounts,GRanges,GRanges-method annotationBlocksCounts,GRangesList,GRanges-method
Forms a mapping between probe locations and chromosomal blocks (regions).annotationBlocksLookup annotationBlocksLookup,data.frame,data.frame-method annotationBlocksLookup,data.frame,GRanges-method
Counts the number of sequencing reads surrounding supplied annotationsannotationCounts annotationCounts,ANY,data.frame-method annotationCounts,ANY,GRanges-method
Forms a mapping between probes on a tiling array and windows surrounding the TSSs of genes.annotationLookup annotationLookup,data.frame,data.frame-method annotationLookup,data.frame,GRanges-method
Read in a (list of) BAM file(s) into a GRanges(List) object.BAM2GRanges BAM2GRanges,character-method BAM2GRangesList BAM2GRangesList,character-method
Class '"BayMethList"'BayMethList BayMethList,GRanges,matrix,matrix,numeric-method BayMethList-class control control,BayMethList-method control<- control<-,BayMethList-method cpgDens cpgDens,BayMethList-method cpgDens<- cpgDens<-,BayMethList-method fOffset fOffset,BayMethList-method fOffset<- fOffset<-,BayMethList-method length length,BayMethList-method maskEmpBayes maskEmpBayes,BayMethList-method maskEmpBayes<- maskEmpBayes<-,BayMethList-method methEst methEst,BayMethList-method methEst<- methEst<-,BayMethList-method ncontrol ncontrol,BayMethList-method nsampleInterest nsampleInterest,BayMethList-method priorTab priorTab,BayMethList-method priorTab<- priorTab<-,BayMethList-method sampleInterest sampleInterest,BayMethList-method sampleInterest<- sampleInterest<-,BayMethList-method show,BayMethList-method windows windows,BayMethList-method windows<- windows<-,BayMethList-method [,BayMethList,ANY,missing,ANY-method
Create line plots of averaged signal across a promoterbinPlots binPlots,ScoresList-method
Calculate statistics for regions in the genomeblocksStats blocksStats,ANY,data.frame-method blocksStats,ANY,GRanges-method
Check Probe Specificity for Some RegionscheckProbes checkProbes,data.frame,data.frame-method checkProbes,GRanges,GRanges-method
Positions of Genes on Human Chromosome 21chr21genes
A function to find areas of enrichment in sequencing dataChromaBlocks ChromaBlocks,GRangesList,GRangesList-method
ChromaResults classblocks blocks,ChromaResults-method ChromaResults ChromaResults-class class:ChromaResults cutoff cutoff,ChromaResults-method FDRTable FDRTable,ChromaResults-method regions regions,ChromaResults-method show,ChromaResults-method
Plot copy number by chromosomechromosomeCNplots chromosomeCNplots,AdjustedCopyEstimate-method chromosomeCNplots,CopyEstimate-method
Container for coverage matrices with clustering results.ClusteredScoresList ClusteredScoresList,ScoresList-method ClusteredScoresList-class clusters clusters,ClusteredScoresList-method show,ClusteredScoresList-method subsetRows,ClusteredScoresList-method [,ClusteredScoresList,ANY,missing,ANY-method
Visualisation of tables of feature coverages.clusterPlots clusterPlots,ClusteredScoresList-method clusterPlots,ScoresList-method
Container for results of fold change copy number estimation.CopyEstimate CopyEstimate,GRanges,matrix,GRangesList,character-method CopyEstimate-class show,CopyEstimate-method
Boxplots of intensity, binned by Cpg DensitycpgBoxplots cpgBoxplots,AffymetrixCelSet-method cpgBoxplots,matrix-method
Calculate CpG Density in a WindowcpgDensityCalc cpgDensityCalc,data.frame,BSgenome-method cpgDensityCalc,GRanges,BSgenome-method cpgDensityCalc,GRangesList,BSgenome-method
Plot the distribution of sequencing reads CpG densities.cpgDensityPlot cpgDensityPlot,GRangesList-method
Function to determine the normalising offset f that accounts for the relative sequencing depth.determineOffset
Function to calculate prior parameters using empirical Bayes.empBayes
Calculate sequencing enrichmentenrichmentCalc enrichmentCalc,GRanges-method enrichmentCalc,GRangesList-method
Plot the distribution of sequencing enrichment.enrichmentPlot enrichmentPlot,GRangesList-method
Vector of expression differencesexpr
FastQC and associated classesBasic_Statistics Basic_Statistics,FastQC-method Basic_Statistics,SequenceQC-method Basic_Statistics,SequenceQCSet-method class:FastQC class:SequenceQC class:SequenceQCSet FastQC-class Mismatches Mismatches,SequenceQC-method Mismatches,SequenceQCSet-method MismatchTable MismatchTable,SequenceQC-method MismatchTable,SequenceQCSet-method Overrepresented_sequences Overrepresented_sequences,FastQC-method Overrepresented_sequences,SequenceQC-method Overrepresented_sequences,SequenceQCSet-method Per_base_GC_content Per_base_GC_content,FastQC-method Per_base_GC_content,SequenceQC-method Per_base_GC_content,SequenceQCSet-method Per_base_N_content Per_base_N_content,FastQC-method Per_base_N_content,SequenceQC-method Per_base_N_content,SequenceQCSet-method Per_base_sequence_content Per_base_sequence_content,FastQC-method Per_base_sequence_content,SequenceQC-method Per_base_sequence_content,SequenceQCSet-method Per_base_sequence_quality Per_base_sequence_quality,FastQC-method Per_base_sequence_quality,SequenceQC-method Per_base_sequence_quality,SequenceQCSet-method Per_sequence_GC_content Per_sequence_GC_content,FastQC-method Per_sequence_GC_content,SequenceQC-method Per_sequence_GC_content,SequenceQCSet-method Per_sequence_quality_scores Per_sequence_quality_scores,FastQC-method Per_sequence_quality_scores,SequenceQC-method Per_sequence_quality_scores,SequenceQCSet-method readFastQC SequenceQC-class SequenceQCSet SequenceQCSet-class Sequence_Duplication_Levels Sequence_Duplication_Levels,FastQC-method Sequence_Duplication_Levels,SequenceQC-method Sequence_Duplication_Levels,SequenceQCSet-method Sequence_Length_Distribution Sequence_Length_Distribution,FastQC-method Sequence_Length_Distribution,SequenceQC-method Sequence_Length_Distribution,SequenceQCSet-method show,FastQC-method show,SequenceQC-method show,SequenceQCSet-method [,SequenceQCSet,ANY,missing,ANY-method
Make windows for distances around a reference point.featureBlocks featureBlocks,data.frame-method featureBlocks,GRanges-method
Get scores at regular sample points around genomic features.featureScores featureScores,ANY,data.frame-method featureScores,ANY,GRanges-method
Find Clusters Epigenetically Modified GenesfindClusters
Calculate Absolute Copy Number from Sequencing CountsGCadjustCopy GCadjustCopy,data.frame,matrix,GCAdjustParams-method GCadjustCopy,GRanges,matrix,GCAdjustParams-method
Container for parameters for mappability and GC content adjusted absolute copy number estimation.GCAdjustParams GCAdjustParams,BSgenome,MappabilitySource-method GCAdjustParams-class
Plot GC content vs. Read Counts Before Normalising, and GC content vs. Copy Estimates After Normalising.GCbiasPlots GCbiasPlots,AdjustedCopyEstimate-method
Calculate The gcContent of a RegiongcContentCalc gcContentCalc,data.frame,BSgenome-method gcContentCalc,GRanges,BSgenome-method
Creates bins across a genome.genomeBlocks genomeBlocks,BSgenome-method genomeBlocks,numeric-method
Plot Quality Checking Information for Sequencing DatagenQC genQC,character-method genQC,SequenceQCSet-method
Translate Affymetrix probe information in a table.getProbePositionsDf getProbePositionsDf,AffymetrixCdfFile-method
Calculates the sample-specific offsets, using the neutral stategetSampleOffsets
Masking files for hg19hcRegions
Gaussian hypergeometric function for vectorial argumentshyperg2F1_vec
A routine to read Nimblegen tiling array intensitiesloadPairFile
A routine to read Nimblegen tiling array intensitiesloadSampleDirectory
Using the output of 'annotationLookup', create a tabular storage of the indicesmakeWindowLookupTable
Calculate The Mappability of a RegionmappabilityCalc mappabilityCalc,data.frame,MappabilitySource-method mappabilityCalc,GRanges,MappabilitySource-method
Superclass for datatypes that can refer to genome mappability data.MappabilitySource MappabilitySource-class
Function to mask suspicious regions.maskOut
Merge GRanges that are of replicate experiments.mergeReplicates mergeReplicates,GRangesList-method
Function to derive regional methylation estimates.methylEst
Superfigure plotsmultiHeatmap
Plot Scores of Cluster RegionsplotClusters plotClusters,data.frame-method plotClusters,GRanges-method
Plotting the response of qDNA-seq data by CNVplotQdnaByCN
Reads in a Nimblegen microarray design file (NDF)processNDF
Create line plots of averaged signal across a promoter for gene sets, compared to random sampling.profilePlots profilePlots,ScoresList-method
A container for quantitative DNA sequencing data for ABCD-DNA analysesclass:QdnaData QdnaData QdnaData-class show,QdnaData-method
Find Regions of significance in microarray dataclass:RegionStats regionStats regionStats,AffymetrixCelSet-method regionStats,matrix-method RegionStats-class show,RegionStats-method
Calculate and Segment Relative Copy Number From Sequencing CountsrelativeCN relativeCN,data.frame,matrix-method relativeCN,GRanges,matrix-method
Short Reads from Cancer and NormalsamplesList
Container for 'featureScores()' output.length,ScoresList-method names,ScoresList-method names<-,ScoresList-method ScoresList ScoresList-class show,ScoresList-method subsetRows subsetRows,ScoresList-method tables tables,ScoresList-method [,ScoresList,ANY,missing,ANY-method
Find occurences of a DNA patternsequenceCalc sequenceCalc,data.frame,BSgenome-method sequenceCalc,GRanges,BSgenome-method
Set the CNVOffsets of a 'QdnaData' objectsetCNVOffsets
Subtract scores of different samples.summarizeScores summarizeScores,ScoresList,matrix-method
Writes sequencing data out into wiggle fileswriteWig writeWig,AffymetrixCelSet-method writeWig,GRangesList-method