MSstatsResponse: A package for detecting drug-protein interactions in dose-response mass spectrometry-based proteomics experiments
Introduction | Statistical framework | Analysis workflow | Installation and setup | Install MSstatsResponse | Load required libraries | Data preprocessing with MSstats | Example MSstats workflow | Loading example data | Data preparation for dose-response analysis | Converting GROUP labels to numeric doses | Formatting data with MSstatsPrepareDoseResponseFit() | Drug-protein interaction detection | Isotonic regression | Running doseResponseFit() | Interpreting results | IC50 estimation | Understanding IC50 calculation | Running predictIC50() | Parallel processing for large datasets | Visualization | Individual protein dose-response curves | Comparing log2 vs ratio scale | Predicting at other response levels | Experimental design planning | Simulating future experiments | Sweeping experimental design parameters | Session information | References