Package: tadar 1.5.0
Lachlan Baer
tadar: Transcriptome Analysis of Differential Allelic Representation
This package provides functions to standardise the analysis of Differential Allelic Representation (DAR). DAR compromises the integrity of Differential Expression analysis results as it can bias expression, influencing the classification of genes (or transcripts) as being differentially expressed. DAR analysis results in an easy-to-interpret value between 0 and 1 for each genetic feature of interest, where 0 represents identical allelic representation and 1 represents complete diversity. This metric can be used to identify features prone to false-positive calls in Differential Expression analysis, and can be leveraged with statistical methods to alleviate the impact of such artefacts on RNA-seq data.
Authors:
tadar_1.5.0.tar.gz
tadar_1.5.0.zip(r-4.5)tadar_1.5.0.zip(r-4.4)tadar_1.3.2.zip(r-4.3)
tadar_1.5.0.tgz(r-4.4-any)tadar_1.3.2.tgz(r-4.3-any)
tadar_1.5.0.tar.gz(r-4.5-noble)tadar_1.5.0.tar.gz(r-4.4-noble)
tadar_1.5.0.tgz(r-4.4-emscripten)tadar_1.3.2.tgz(r-4.3-emscripten)
tadar.pdf |tadar.html✨
tadar/json (API)
NEWS
| # Install 'tadar' in R: |
| install.packages('tadar', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/baerlachlan/tadar/issues
- chr1_genes - Genomic feature example data
- chr1_tt - Differential expression example data
On BioConductor:tadar-1.5.0(bioc 3.21)tadar-1.4.0(bioc 3.20)
sequencingrnaseqsnpgenomicvariationvariantannotationdifferentialexpression
Last updated 2 months agofrom:9f7bb4f9c7. Checks:OK: 5 WARNING: 2. Indexed: yes.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Nov 28 2024 |
| R-4.5-win | OK | Nov 28 2024 |
| R-4.5-linux | OK | Nov 28 2024 |
| R-4.4-win | OK | Nov 28 2024 |
| R-4.4-mac | OK | Nov 28 2024 |
| R-4.3-win | WARNING | Sep 24 2024 |
| R-4.3-mac | WARNING | Sep 24 2024 |
Exports:assignFeatureDarcountAllelescountsToPropsdarfilterLociflipRangesmodPplotChrDarplotDarECDFreadGenotypesunphaseGT
Dependencies:abindAnnotationDbiAnnotationFilteraskpassbackportsbase64encBHBiobaseBiocFileCacheBiocGenericsBiocIOBiocParallelbiomaRtBiostringsbiovizBasebitbit64bitopsblobBSgenomebslibcachemcheckmatecliclustercodetoolscolorspacecpp11crayoncurldata.tableDBIdbplyrDelayedArraydeldirdichromatdigestdplyrensembldbevaluatefansifarverfastmapfilelockfontawesomeforeignformatRFormulafsfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicFeaturesGenomicRangesggplot2gluegridExtragtableGvizhighrHmischmshtmlTablehtmltoolshtmlwidgetshttrhttr2interpIRangesisobandjpegjquerylibjsonliteKEGGRESTknitrlabelinglambda.rlatticelatticeExtralazyevallifecyclemagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemunsellnlmennetopensslpillarpkgconfigplogrpngprettyunitsprogressProtGenericspurrrR6rappdirsRColorBrewerRcppRcppEigenRCurlrestfulrRhtslibrjsonrlangrmarkdownrpartRsamtoolsRSQLiterstudioapirtracklayerS4ArraysS4VectorssassscalessnowSparseArraystringistringrSummarizedExperimentsystibbletidyrtidyselecttinytexUCSC.utilsutf8VariantAnnotationvctrsviridisviridisLitewithrxfunXMLxml2XVectoryamlzlibbioc
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Assign DAR values to genomic features | assignFeatureDar assignFeatureDar,GRangesList,GRanges-method |
| Genomic feature example data | chr1_genes |
| Differential expression example data | chr1_tt |
| Count alleles within each experimental group | countAlleles countAlleles,GRanges,list-method |
| Convert allele counts to proportions | countsToProps countsToProps,GRangesList-method |
| Calculate Differential Allelic Representation (DAR) | dar dar,GRangesList,matrix-method |
| Filter loci | filterLoci filterLoci,GRangesList-method |
| Convert DAR origin ranges to DAR region ranges, or vice versa | flipRanges flipRanges,GRangesList-method |
| DAR-moderated _p_-values | modP modP,numeric,numeric-method |
| Plot DAR across a chromosome | plotChrDar plotChrDar,GRanges-method |
| Plot the Empirical Cumulative Distribution Function of DAR | plotDarECDF plotDarECDF,GRanges-method |
| Read genotypes from a VCF file | readGenotypes readGenotypes,character-method readGenotypes,TabixFile-method |
| Unphase genotypes | unphaseGT unphaseGT,data.frame-method unphaseGT,matrix-method |
