Package: scGraphVerse 1.3.0

Francesco Cecere

scGraphVerse: scGraphVerse: A Gene Network Analysis Package

A package for inferring, comparing, and visualizing gene networks from single-cell RNA sequencing data. It integrates multiple methods (GENIE3, GRNBoost2, ZILGM, PCzinb, and JRF) for robust network inference, supports consensus building across methods or datasets, and provides tools for evaluating regulatory structure and community similarity. GRNBoost2 requires Python package 'arboreto' which can be installed using init_py(install_missing = TRUE). This package includes adapted functions from ZILGM (Park et al., 2021), JRF (Petralia et al., 2015), and learn2count (Nguyen et al. 2023) packages with proper attribution under GPL-2 license.

Authors:Francesco Cecere [aut, cre], Annamaria Carissimo [aut], Daniela De Canditiis [aut], Claudia Angelini [aut, fnd]

scGraphVerse_1.3.0.tar.gz
scGraphVerse_1.3.0.zip(r-4.7)scGraphVerse_1.3.0.zip(r-4.6)scGraphVerse_1.3.0.zip(r-4.5)
scGraphVerse_1.3.0.tgz(r-4.6-x86_64)scGraphVerse_1.3.0.tgz(r-4.6-arm64)scGraphVerse_1.3.0.tgz(r-4.5-x86_64)scGraphVerse_1.3.0.tgz(r-4.5-arm64)
scGraphVerse_1.3.0.tar.gz(r-4.7-arm64)scGraphVerse_1.3.0.tar.gz(r-4.7-x86_64)scGraphVerse_1.3.0.tar.gz(r-4.6-arm64)scGraphVerse_1.3.0.tar.gz(r-4.6-x86_64)
scGraphVerse_1.3.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
scGraphVerse/json (API)
NEWS

# Install 'scGraphVerse' in R:
install.packages('scGraphVerse', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/ngsfc/scgraphverse/issues

Pkgdown/docs site:https://ngsfc.github.io

Datasets:

On BioConductor:scGraphVerse-1.3.0(bioc 3.24)scGraphVerse-1.2.0(bioc 3.23)

generegulationnetworkinferencesinglecellrnaseqvisualizationsoftwaregraphandnetworkgenesetenrichmentnetworkenrichmentpathwayssequencingreactomenetworkkegg

5.11 score 1 stars 4 scripts 192 downloads 26 exports 94 dependencies

Last updated from:9153b37355. Checks:9 NOTE, 2 OK, 3 ERROR. Indexed: yes.

TargetResultTimeFilesSyslog
bioc-checksNOTE444
linux-devel-arm64NOTE941
linux-devel-x86_64NOTE1103
source / vignettesOK846
linux-release-arm64NOTE981
linux-release-x86_64NOTE1154
macos-release-arm64NOTE716
macos-release-x86_64NOTE1148
macos-oldrel-arm64NOTE768
macos-oldrel-x86_64NOTE1144
windows-develERROR2058
windows-releaseERROR1666
windows-oldrelERROR2088
wasm-releaseOK410

Exports:build_network_seclassify_edgescommunity_pathcommunity_similaritycompare_consensuscompute_community_metricscompute_topology_metricscreate_consensuscreate_maecutoff_adjacencydownload_Atlasearlyjedge_mininggenerate_adjacencyinfer_networksinit_pyPCzinbplot_community_comparisonplot_network_comparisonplotgplotROCpscoresselgenestringdb_adjacencysymmetrizezinb_simdata

Dependencies:abindaskpassBHBiobaseBiocBaseUtilsBiocGenericsBiocParallelbstclicodetoolscpp11curlDelayedArraydigestdistributions3doParalleldoRNGdplyrfarverforeachformatRfutile.loggerfutile.optionsgbmgenericsGENIE3GenomicRangesggplot2glmnetgluegraphgtableherehttrigraphIRangesisobanditeratorsjsonlitelabelinglambda.rlatticelifecyclemagrittrMASSMatrixMatrixGenericsmatrixStatsmimempathMultiAssayExperimentnumDerivopensslpillarpkgconfigplyrpngpsclpurrrR6rappdirsRColorBrewerRcppRcppEigenRcppTOMLreshape2reticulaterlangrngtoolsrpartrprojrootS4ArraysS4VectorsS7scalesSeqinfoshapeSingleCellExperimentsnowSparseArraystringistringrSummarizedExperimentsurvivalsystibbletidyrtidyselectutf8vctrsviridisLiteWeightSVMwithrXVector

scGraphVerse Case Study: B-cell GRN Reconstruction

Rendered fromcase_study.Rmdusingknitr::rmarkdownon May 30 2026.

Last update: 2025-10-12
Started: 2025-05-05

scGraphVerse Case Study: Zero-Inflated Simulation and GRN Inference

Rendered fromsimulation_study.Rmdusingknitr::rmarkdownon May 30 2026.

Last update: 2025-10-12
Started: 2025-05-05

Readme and manuals

Help Manual

Help pageTopics
Create a SummarizedExperiment for Network Storagebuild_network_se
Classify Edges as TP, FP, or FNclassify_edges
Community Detection and Pathway Enrichment Analysiscommunity_path
Compare Community Assignments and Topological Propertiescommunity_similarity
Compare Consensus and Reference Graphs or STRINGdb Networkscompare_consensus
Compute Community Assignment Similarity Metricscompute_community_metrics
Compute Network Topological Propertiescompute_topology_metrics
Create a Consensus Adjacency Matrix from Multiple Networkscreate_consensus
Create MultiAssayExperiment from Multiple Single-Cell Datasetscreate_mae
Threshold Adjacency Matrices Based on Shuffled Network Quantilescutoff_adjacency
Download and Load an RDS File from a URLdownload_Atlas
Modify Cell Names and Combine Datasetsearlyj
Edge Mining of Gene Interactions Using PubMededge_mining
Generate Adjacency Matrices from Gene Interaction Tablesgenerate_adjacency
Infer Gene Regulatory Networks from Expression Matricesinfer_networks
Initialize Python Environment for GRNBoost2init_py
Structure learning for count data using PC algorithmsPCzinb
Visualize Community and Topology Comparisonplot_community_comparison
Visualize Network Comparisonplot_network_comparison
Visualize Graphs from Adjacency Matricesplotg
Plot ROC Curves for Inferred NetworksplotROC
Compute Performance Scores for Predicted Adjacency Matricespscores
Select Top Expressed Genes from Single-Cell Dataselgene
Build Adjacency Matrices for Physical Interactions from STRING (POST API)stringdb_adjacency
Symmetrize Adjacency Matrices in a SummarizedExperimentsymmetrize
Toy adjacency matrix for examplestoy_adj_matrix
Toy MultiAssayExperiment for Network Inferencetoy_counts
Simulate Zero-Inflated Negative Binomial (ZINB) Count Matrices with Sequencing Depthzinb_simdata