Package: derfinder 1.41.0

Leonardo Collado-Torres

derfinder: Annotation-agnostic differential expression analysis of RNA-seq data at base-pair resolution via the DER Finder approach

This package provides functions for annotation-agnostic differential expression analysis of RNA-seq data. Two implementations of the DER Finder approach are included in this package: (1) single base-level F-statistics and (2) DER identification at the expressed regions-level. The DER Finder approach can also be used to identify differentially bounded ChIP-seq peaks.

Authors:Leonardo Collado-Torres [aut, cre], Alyssa C. Frazee [ctb], Andrew E. Jaffe [aut], Jeffrey T. Leek [aut, ths]

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derfinder.pdf |derfinder.html
derfinder/json (API)
NEWS

# Install 'derfinder' in R:
install.packages('derfinder', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/lcolladotor/derfinder/issues

Datasets:

On BioConductor:derfinder-1.39.0(bioc 3.20)derfinder-1.38.0(bioc 3.19)

differentialexpressionsequencingrnaseqchipseqdifferentialpeakcallingsoftwareimmunooncologycoverageannotation-agnosticbioconductorderfinder

9.07 score 42 stars 6 packages 77 scripts 916 downloads 26 exports 134 dependencies

Last updated 23 days agofrom:216267d650. Checks:OK: 1 NOTE: 4 ERROR: 2. Indexed: yes.

TargetResultDate
Doc / VignettesOKOct 30 2024
R-4.5-winNOTEOct 30 2024
R-4.5-linuxNOTEOct 30 2024
R-4.4-winNOTEOct 30 2024
R-4.4-macERROROct 31 2024
R-4.3-winNOTEOct 30 2024
R-4.3-macERROROct 31 2024

Exports:advancedArganalyzeChrannotateRegionscalculatePvaluescalculateStatscoerceGRcollapseFullCoveragecoverageToExoncreateBwcreateBwSampledefine_clusterextendedMapSeqlevelsfilterDatafindRegionsfullCoveragegetRegionCoveragegetTotalMappedloadCoveragemakeGenomicStatemakeModelsmergeResultspreprocessCoveragerailMatrixrawFilesregionMatrixsampleDepth

Dependencies:abindAnnotationDbiaskpassbackportsbase64encBHBiobaseBiocGenericsBiocIOBiocParallelBiostringsbitbit64bitopsblobBSgenomebslibbumphuntercachemcheckmatecliclustercodetoolscolorspacecpp11crayoncurldata.tableDBIDelayedArrayderfinderHelperdigestdoRNGevaluatefansifarverfastmapfontawesomeforeachforeignformatRFormulafsfutile.loggerfutile.optionsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicFeaturesGenomicFilesGenomicRangesggplot2gluegridExtragtablehighrHmischtmlTablehtmltoolshtmlwidgetshttrIRangesisobanditeratorsjquerylibjsonliteKEGGRESTknitrlabelinglambda.rlatticelifecyclelimmalocfitmagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemunsellnlmennetopensslpillarpkgconfigplogrplyrpngqvalueR6rappdirsRColorBrewerRcppRCurlreshape2restfulrRhtslibrjsonrlangrmarkdownrngtoolsrpartRsamtoolsRSQLiterstudioapirtracklayerS4ArraysS4VectorssassscalessnowSparseArraystatmodstringistringrSummarizedExperimentsystibbletinytexUCSC.utilsutf8VariantAnnotationvctrsviridisviridisLitewithrxfunXMLXVectoryamlzlibbioc

derfinder quick start guide

Rendered fromderfinder-quickstart.Rmdusingknitr::rmarkdownon Oct 30 2024.

Last update: 2021-05-02
Started: 2015-12-09

derfinder users guide

Rendered fromderfinder-users-guide.Rmdusingknitr::rmarkdownon Oct 30 2024.

Last update: 2020-12-17
Started: 2015-11-11

Readme and manuals

Help Manual

Help pageTopics
Run the derfinder analysis on a chromosomeanalyzeChr
Assign genomic states to regionsannotateRegions
Calculate p-values and identify regionscalculatePvalues
Calculate F-statistics at base pair resolution from a loaded BAM filescalculateStats
Coerce the coverage to a GRanges object for a given samplecoerceGR
Collapse full coverage information for efficient quantile computationscollapseFullCoverage
Extract coverage information for exonscoverageToExon
Export coverage to BigWig filescreateBw
Create a BigWig file with the coverage information for a given samplecreateBwSample
Define a cluster to use.define_cluster
Deprecated functions in package 'derfinder'advancedArg derfinder-deprecated
Change naming style for a set of sequence namesextendedMapSeqlevels
Filter the positions of interestfilterData
Find non-zero regions in a RlefindRegions
Load the unfiltered coverage information from a group of BAM files and a list of chromosomesfullCoverage
Genome samples processed datagenomeData
Genome samples processed datagenomeDataRaw
F-statistics for the example datagenomeFstats
Genome samples informationgenomeInfo
Candidate DERs for example datagenomeRegions
Genomic State for Hsapiens.UCSC.hg19.knownGenegenomicState
Extract coverage information for a set of regionsgetRegionCoverage
Calculate the total number of mapped readsgetTotalMapped
Load the coverage information from a group of BAM filesloadCoverage
Obtain the genomic state per region from annotationmakeGenomicState
Build model matrices for differential expressionmakeModels
Merge results from different chromosomesmergeResults
Transform and split the datapreprocessCoverage
Identify regions data by a coverage filter and get a count matrix from BigWig filesrailMatrix
Construct full paths to a group of raw input filesrawFiles
Identify regions data by a coverage filter and get a count matrixregionMatrix
Calculate adjustments for library sizesampleDepth