Package: dearseq 1.25.0

Boris P. Hejblum

dearseq: Differential Expression Analysis for RNA-seq data through a robust variance component test

Differential Expression Analysis RNA-seq data with variance component score test accounting for data heteroscedasticity through precision weights. Perform both gene-wise and gene set analyses, and can deal with repeated or longitudinal data. Methods are detailed in: i) Agniel D & Hejblum BP (2017) Variance component score test for time-course gene set analysis of longitudinal RNA-seq data, Biostatistics, 18(4):589-604 ; and ii) Gauthier M, Agniel D, Thiébaut R & Hejblum BP (2020) dearseq: a variance component score test for RNA-Seq differential analysis that effectively controls the false discovery rate, NAR Genomics and Bioinformatics, 2(4):lqaa093.

Authors:Denis Agniel [aut], Boris P. Hejblum [aut, cre], Marine Gauthier [aut], Mélanie Huchon [ctb]

dearseq_1.25.0.tar.gz
dearseq_1.25.0.zip(r-4.7)dearseq_1.25.0.zip(r-4.6)dearseq_1.25.0.zip(r-4.5)
dearseq_1.25.0.tgz(r-4.6-any)dearseq_1.25.0.tgz(r-4.5-any)
dearseq_1.25.0.tar.gz(r-4.7-any)dearseq_1.25.0.tar.gz(r-4.6-any)
dearseq_1.25.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
dearseq/json (API)
NEWS

# Install 'dearseq' in R:
install.packages('dearseq', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/borishejblum/dearseq/issues

Datasets:
  • baduel_gmt - Small portion of RNA-seq data from plant physiology study.
  • design - Small portion of RNA-seq data from plant physiology study.
  • expr_norm_corr - Small portion of RNA-seq data from plant physiology study.
  • PBT_gmt - PBT gene sets related to kidney transplant

On BioConductor:dearseq-1.25.0(bioc 3.24)dearseq-1.24.0(bioc 3.23)

biomedicalinformaticscellbiologydifferentialexpressiondnaseqgeneexpressiongeneticsgenesetenrichmentimmunooncologykeggregressionrnaseqsequencingsystemsbiologytimecoursetranscriptiontranscriptomics

6.33 score 8 stars 1 packages 15 scripts 546 downloads 15 exports 46 dependencies

Last updated from:568dec0cec. Checks:1 WARNING, 7 NOTE, 2 OK. Indexed: yes.

TargetResultTimeFilesSyslog
bioc-checksWARNING210
linux-devel-x86_64NOTE258
source / vignettesOK489
linux-release-x86_64NOTE227
macos-release-arm64NOTE155
macos-oldrel-arm64NOTE127
windows-develNOTE166
windows-releaseNOTE142
windows-oldrelNOTE148
wasm-releaseOK152

Exports:dear_seqdgsa_seqpermPvalsplot_hist_pvalsplot_ord_pvalsplot_weightssp_weightsspaghettiPlot1GSvc_scorevc_score_hvc_score_h_permvc_score_permvc_test_asymvc_test_permvoom_weights

Dependencies:cliCompQuadFormcpp11DBIdplyrfarvergenericsggplot2gluegtableisobandKernSmoothlabelinglatticelifecyclemagrittrMatrixmatrixStatsminqamitoolsnumDerivpatchworkpbapplypillarpkgconfigplyrR6RColorBrewerRcppRcppArmadilloreshape2rlangS7scalesscattermorestatmodstringistringrsurveysurvivaltibbletidyselectutf8vctrsviridisLitewithr

User guide to the dearseq R package

Rendered fromdearseqUserguide.Rmdusingknitr::rmarkdownon May 28 2026.

Last update: 2022-02-01
Started: 2019-05-16