Package: ISLET 1.9.0

Hao Feng

ISLET: Individual-Specific ceLl typE referencing Tool

ISLET is a method to conduct signal deconvolution for general -omics data. It can estimate the individual-specific and cell-type-specific reference panels, when there are multiple samples observed from each subject. It takes the input of the observed mixture data (feature by sample matrix), and the cell type mixture proportions (sample by cell type matrix), and the sample-to-subject information. It can solve for the reference panel on the individual-basis and conduct test to identify cell-type-specific differential expression (csDE) genes. It also improves estimated cell type mixture proportions by integrating personalized reference panels.

Authors:Hao Feng [aut, cre], Qian Li [aut], Guanqun Meng [aut]

ISLET_1.9.0.tar.gz
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ISLET.pdf |ISLET.html✨
ISLET/json (API)
NEWS

# Install 'ISLET' in R:
install.packages('ISLET', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))
Datasets:
  • GE600_se - ISLET deconvolution example raw input data
  • GE600age_se - ISLET example datasets for slope variable testing in csDE

On BioConductor:ISLET-1.9.0(bioc 3.21)ISLET-1.8.0(bioc 3.20)

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

softwarernaseqtranscriptomicstranscriptionsequencinggeneexpressiondifferentialexpressiondifferentialmethylation

4.00 score 9 scripts 220 downloads 8 exports 56 dependencies

Last updated 4 months agofrom:7137eb91dd. Checks:3 OK, 1 WARNING, 4 NOTE. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKFeb 13 2025
R-4.5-winOKFeb 13 2025
R-4.5-macWARNINGFeb 13 2025
R-4.5-linuxOKFeb 13 2025
R-4.4-winNOTEFeb 13 2025
R-4.4-macNOTEFeb 13 2025
R-4.3-winNOTEFeb 13 2025
R-4.3-macNOTEFeb 13 2025

Exports:caseEstctrlEstdataPrepdataPrepSlopeimplyimplyDataPrepisletSolveisletTest

Dependencies:abindaskpassBHBiobaseBiocGenericsBiocParallelbootclicodetoolscpp11crayoncurlDelayedArrayformatRfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicRangesgluehttrIRangesjsonlitelambda.rlatticelifecyclelme4magrittrMASSMatrixMatrixGenericsmatrixStatsmimeminqanlmenloptrnnlsopensslpurrrR6rbibutilsRcppRcppEigenRdpackreformulasrlangS4ArraysS4VectorssnowSparseArraySummarizedExperimentsysUCSC.utilsvctrsXVector

Individual-specific and cell-type-specific deconvolution using ISLET

Hao Feng, Qian Li, Guanqun Meng

Rendered fromISLET.Rmdusingknitr::rmarkdownon Feb 13 2025.

Last update: 2023-09-15
Started: 2022-06-15