Package: DriverNet 1.47.0

Jiarui Ding

DriverNet: Drivernet: uncovering somatic driver mutations modulating transcriptional networks in cancer

DriverNet is a package to predict functional important driver genes in cancer by integrating genome data (mutation and copy number variation data) and transcriptome data (gene expression data). The different kinds of data are combined by an influence graph, which is a gene-gene interaction network deduced from pathway data. A greedy algorithm is used to find the possible driver genes, which may mutated in a larger number of patients and these mutations will push the gene expression values of the connected genes to some extreme values.

Authors:Ali Bashashati, Reza Haffari, Jiarui Ding, Gavin Ha, Kenneth Liu, Jamie Rosner and Sohrab Shah

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DriverNet.pdf |DriverNet.html
DriverNet/json (API)

# Install 'DriverNet' in R:
install.packages('DriverNet', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:

On BioConductor:DriverNet-1.45.0(bioc 3.20)DriverNet-1.44.0(bioc 3.19)

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

network

3.30 score 7 scripts 190 downloads 8 exports 0 dependencies

Last updated 23 days agofrom:a5b4009391. Checks:OK: 1 NOTE: 6. Indexed: yes.

TargetResultDate
Doc / VignettesOKOct 30 2024
R-4.5-winNOTEOct 30 2024
R-4.5-linuxNOTEOct 30 2024
R-4.4-winNOTEOct 30 2024
R-4.4-macNOTEOct 30 2024
R-4.3-winNOTEOct 30 2024
R-4.3-macNOTEOct 30 2024

Exports:actualEventscomputeDriverscomputeRandomizedResultdriversgetPatientOutlierMatrixpreprocessMatricesresultSummarytotalEvents

Dependencies:

An introduction to DriverNet

Rendered fromDriverNet-Overview.Rnwusingutils::Sweaveon Oct 30 2024.

Last update: 2013-11-01
Started: 2013-11-01

Readme and manuals

Help Manual

Help pageTopics
Drivernet: uncovering somatic driver mutations modulating transcriptional networks in cancerDriverNet-package DriverNet
Actual events covered by driver mutationsactualEvents
Compute a list of driver mutationscomputeDrivers
Randomly compute lists of driver mutationscomputeRandomizedResult
Class '"DriverNetResult"'actualEvents,DriverNetResult-method DriverNetResult-class drivers,DriverNetResult-method totalEvents,DriverNetResult-method
List of driver mutations identified by DriverNetdrivers
Compute the patient outlier matrixgetPatientOutlierMatrix
Remove unnecessary entries from matricespreprocessMatrices
Summarize result for drivers ranking.resultSummary
Sample DriverNet resultsampleDriversList
Sample gene namessampleGeneNames
Sample influence graphsampleInfluenceGraph
Sample patient expression matrixsamplePatientExpressionMatrix
Sample patient mutation matrixsamplePatientMutationMatrix
Sample patient outlier matrixsamplePatientOutlierMatrix
Sample Result from computeRandomizedResultsampleRandomDriversResult
Total number of events in the datatotalEvents