Workflow Demonstration for Deep characterization of cancer drugs
Introduction | Part I: Core Analysis | Data Loading and Preparation | Computing Similarity Between Drug Treatment and Gene Knockout | Predicting Similarity Across Known Targeted Genes and All Genes | Computing the Interaction | Interaction Assessment | Preparation for Output | In addition to the output of prediction object, we also identify drugs with low primary target expressing cell lines | Calculating Drug KO Similarities in cell lines with low primary target | Part II: Application | Finding and visualizing a drug primary target | Predicting whether the drug specifically targets the wild-type or mutated target forms | Predicting secondary target(s) that mediate its response when the primary target is not expressed | Part III: Conclusion | Session info