Package: mitoClone2 1.13.0

Benjamin Story

mitoClone2: Clonal Population Identification in Single-Cell RNA-Seq Data using Mitochondrial and Somatic Mutations

This package primarily identifies variants in mitochondrial genomes from BAM alignment files. It filters these variants to remove RNA editing events then estimates their evolutionary relationship (i.e. their phylogenetic tree) and groups single cells into clones. It also visualizes the mutations and providing additional genomic context.

Authors:Benjamin Story [aut, cre], Lars Velten [aut], Gregor Mönke [aut]

mitoClone2_1.13.0.tar.gz
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mitoClone2_1.13.0.tgz(r-4.5-arm64)mitoClone2_1.13.0.tgz(r-4.4-arm64)mitoClone2_1.13.0.tgz(r-4.3-arm64)
mitoClone2_1.13.0.tar.gz(r-4.5-noble)mitoClone2_1.13.0.tar.gz(r-4.4-noble)
mitoClone2.pdf |mitoClone2.html
mitoClone2/json (API)
NEWS

# Install 'mitoClone2' in R:
install.packages('mitoClone2', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/benstory/mitoclone2/issues

Uses libs:
  • curl– Easy-to-use client-side URL transfer library
  • bzip2– High-quality block-sorting file compressor library
  • xz-utils– XZ-format compression library
  • zlib– Compression library
  • c++– GNU Standard C++ Library v3
Datasets:
  • M_P1 - Mitochondrial exclusionlist
  • M_P2 - Mitochondrial exclusionlist
  • N_P1 - Mitochondrial exclusionlist
  • N_P2 - Mitochondrial exclusionlist

On BioConductor:mitoClone2-1.13.0(bioc 3.21)mitoClone2-1.12.0(bioc 3.20)

annotationdataimportgeneticssnpsoftwaresinglecellalignmentcurlbzip2xz-utilszlibcpp

4.48 score 1 stars 9 scripts 243 downloads 19 exports 97 dependencies

Last updated 4 months agofrom:020fb39470. Checks:1 OK, 7 WARNING. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKFeb 17 2025
R-4.5-win-x86_64WARNINGFeb 17 2025
R-4.5-mac-aarch64WARNINGFeb 17 2025
R-4.5-linux-x86_64WARNINGFeb 17 2025
R-4.4-win-x86_64WARNINGFeb 17 2025
R-4.4-mac-aarch64WARNINGFeb 17 2025
R-4.3-win-x86_64WARNINGFeb 17 2025
R-4.3-mac-aarch64WARNINGFeb 17 2025

Exports:bam2R_10xbaseCountsFromBamListclusterMetaclonesgetAlleleCountgetCloneLikelihoodgetMut2ClonegetVarsCandidatemitoPlotmut2GRmutationCallsFromCohortmutationCallsFromExclusionlistmutationCallsFromMatrixoverwriteMetaclonesplotClonespullcountsVarsquick_clusterremoveWindowsetVarsCandidatevarCluster

Dependencies:abindAnnotationDbiaskpassBHBiobaseBiocGenericsBiocIOBiocParallelBiostringsbitbit64bitopsblobBSgenomecachemclicodetoolscolorspacecpp11crayoncurlDBIdeepSNVDelayedArrayfansifarverfastmapformatRfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicFeaturesGenomicRangesggplot2gluegtablehttrIRangesisobandjsonliteKEGGRESTlabelinglambda.rlatticelifecyclemagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemunsellnlmeopensslpheatmappillarpkgconfigplogrplyrpngR6RColorBrewerRcppRCurlreshape2restfulrRhtslibrjsonrlangRsamtoolsRSQLitertracklayerS4ArraysS4VectorsscalessnowSparseArraystringistringrSummarizedExperimentsystibbleUCSC.utilsutf8VariantAnnotationvctrsVGAMviridisLitewithrXMLXVectoryaml

Computation of phylogenetic trees and clustering of mutations

Rendered fromclustering.Rmdusingknitr::rmarkdownon Feb 17 2025.

Last update: 2021-07-15
Started: 2021-06-20

Variant Calling

Rendered fromoverview.Rmdusingknitr::rmarkdownon Feb 17 2025.

Last update: 2021-07-19
Started: 2021-06-20