Package: mitoClone2 1.13.0

Benjamin Story

mitoClone2: Clonal Population Identification in Single-Cell RNA-Seq Data using Mitochondrial and Somatic Mutations

This package primarily identifies variants in mitochondrial genomes from BAM alignment files. It filters these variants to remove RNA editing events then estimates their evolutionary relationship (i.e. their phylogenetic tree) and groups single cells into clones. It also visualizes the mutations and providing additional genomic context.

Authors:Benjamin Story [aut, cre], Lars Velten [aut], Gregor Mönke [aut]

mitoClone2_1.13.0.tar.gz
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mitoClone2_1.13.0.tgz(r-4.4-arm64)mitoClone2_1.13.0.tgz(r-4.3-arm64)
mitoClone2_1.13.0.tar.gz(r-4.5-noble)mitoClone2_1.13.0.tar.gz(r-4.4-noble)
mitoClone2.pdf |mitoClone2.html
mitoClone2/json (API)
NEWS

# Install 'mitoClone2' in R:
install.packages('mitoClone2', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/benstory/mitoclone2/issues

Uses libs:
  • curl– Easy-to-use client-side URL transfer library
  • bzip2– High-quality block-sorting file compressor library
  • xz-utils– XZ-format compression library
  • zlib– Compression library
  • c++– GNU Standard C++ Library v3
Datasets:
  • M_P1 - Mitochondrial exclusionlist
  • M_P2 - Mitochondrial exclusionlist
  • N_P1 - Mitochondrial exclusionlist
  • N_P2 - Mitochondrial exclusionlist

On BioConductor:mitoClone2-1.13.0(bioc 3.21)mitoClone2-1.12.0(bioc 3.20)

annotationdataimportgeneticssnpsoftwaresinglecellalignmentcurlbzip2xz-utilszlibcpp

4.48 score 1 stars 8 scripts 204 downloads 19 exports 98 dependencies

Last updated 2 months agofrom:020fb39470. Checks:OK: 1 WARNING: 6. Indexed: yes.

TargetResultDate
Doc / VignettesOKDec 19 2024
R-4.5-win-x86_64WARNINGDec 19 2024
R-4.5-linux-x86_64WARNINGDec 19 2024
R-4.4-win-x86_64WARNINGDec 19 2024
R-4.4-mac-aarch64WARNINGDec 19 2024
R-4.3-win-x86_64WARNINGDec 19 2024
R-4.3-mac-aarch64WARNINGDec 19 2024

Exports:bam2R_10xbaseCountsFromBamListclusterMetaclonesgetAlleleCountgetCloneLikelihoodgetMut2ClonegetVarsCandidatemitoPlotmut2GRmutationCallsFromCohortmutationCallsFromExclusionlistmutationCallsFromMatrixoverwriteMetaclonesplotClonespullcountsVarsquick_clusterremoveWindowsetVarsCandidatevarCluster

Dependencies:abindAnnotationDbiaskpassBHBiobaseBiocGenericsBiocIOBiocParallelBiostringsbitbit64bitopsblobBSgenomecachemclicodetoolscolorspacecpp11crayoncurlDBIdeepSNVDelayedArrayfansifarverfastmapformatRfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicAlignmentsGenomicFeaturesGenomicRangesggplot2gluegtablehttrIRangesisobandjsonliteKEGGRESTlabelinglambda.rlatticelifecyclemagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemunsellnlmeopensslpheatmappillarpkgconfigplogrplyrpngR6RColorBrewerRcppRCurlreshape2restfulrRhtslibrjsonrlangRsamtoolsRSQLitertracklayerS4ArraysS4VectorsscalessnowSparseArraystringistringrSummarizedExperimentsystibbleUCSC.utilsutf8VariantAnnotationvctrsVGAMviridisLitewithrXMLXVectoryamlzlibbioc

Computation of phylogenetic trees and clustering of mutations

Rendered fromclustering.Rmdusingknitr::rmarkdownon Dec 19 2024.

Last update: 2021-07-15
Started: 2021-06-20

Variant Calling

Rendered fromoverview.Rmdusingknitr::rmarkdownon Dec 19 2024.

Last update: 2021-07-19
Started: 2021-06-20