Package: SomaticSignatures 2.49.0

Julian Gehring

SomaticSignatures: Somatic Signatures

The SomaticSignatures package identifies mutational signatures of single nucleotide variants (SNVs). It provides a infrastructure related to the methodology described in Nik-Zainal (2012, Cell), with flexibility in the matrix decomposition algorithms.

Authors:Julian Gehring

SomaticSignatures_2.49.0.tar.gz
SomaticSignatures_2.49.0.zip(r-4.7)SomaticSignatures_2.49.0.zip(r-4.6)SomaticSignatures_2.49.0.zip(r-4.5)
SomaticSignatures_2.49.0.tgz(r-4.6-any)SomaticSignatures_2.49.0.tgz(r-4.5-any)
SomaticSignatures_2.49.0.tar.gz(r-4.7-any)SomaticSignatures_2.49.0.tar.gz(r-4.6-any)
manual.pdf |manual.html✨
card.svg |card.png
SomaticSignatures/json (API)
NEWS

# Install 'SomaticSignatures' in R:

install.packages('SomaticSignatures', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/juliangehring/somaticsignatures/issues

Datasets:

k3we - Kmer datasets
k3wg - Kmer datasets
sca_mm - SomaticCancerAlterations Results
sca_motifs_tiny - SomaticCancerAlterations Results
signatures21 - 21 Signatures
sigs_nmf - SomaticCancerAlterations Results
sigs_pca - SomaticCancerAlterations Results

On BioConductor:SomaticSignatures-2.49.0(bioc 3.24)SomaticSignatures-2.48.0(bioc 3.23)

sequencing somaticmutation visualization clustering genomicvariation statisticalmethod

7.18 score 23 stars 1 packages 73 scripts 558 downloads 32 mentions 37 exports 137 dependencies

Last updated from:4a8c707c3c. Checks:3 ERROR, 5 NOTE, 1 OK, 1 FAIL. Indexed: yes.

Target	Result	Time
bioc-checks	ERROR	291
linux-devel-x86_64	NOTE	672
source / vignettes	OK	481
linux-release-x86_64	NOTE	624
macos-release-arm64	ERROR	504
macos-oldrel-arm64	ERROR	376
windows-devel	NOTE	537
windows-release	NOTE	516
windows-oldrel	NOTE	509
wasm-release	FAIL	261

Exports:assessNumberSignatures clusterSpectrum fitted gcContent hsAllosomes hsAutosomes hsLinear hsToplevel identifySignatures kmerFrequency motifMatrix mutationContext mutationContextMutect mutationDistance ncbi nmfDecomposition nmfSignatures normalizeMotifs observed pcaDecomposition pcaSignatures plotFittedSpectrum plotMutationSpectrum plotNumberSignatures plotObservedSpectrum plotRainfall plotSampleMap plotSamples plotSignatureMap plotSignatures plotVariantAbundance readMutect samples seqchar show signatures ucsc

Dependencies:abind AnnotationDbi AnnotationFilter askpass backports base64enc BH Biobase BiocBaseUtils BiocGenerics BiocIO BiocManager BiocParallel Biostrings biovizBase bit bit64 bitops blob BSgenome bslib cachem checkmate cigarillo cli cluster codetools colorspace cpp11 crayon curl data.table DBI DelayedArray dichromat digest doParallel ensembldb evaluate farver fastmap fontawesome foreach foreign formatR Formula fs futile.logger futile.options generics GenomeInfoDb GenomicAlignments GenomicFeatures GenomicRanges ggbio ggplot2 glue graph gridBase gridExtra gtable highr Hmisc htmlTable htmltools htmlwidgets httr IRanges isoband iterators jquerylib jsonlite KEGGREST knitr labeling lambda.r lattice lazyeval lifecycle magrittr MASS Matrix MatrixGenerics matrixStats memoise mime NMF nnet openssl OrganismDbi pcaMethods pkgconfig plyr png ProtGenerics proxy R6 rappdirs RBGL RColorBrewer Rcpp RCurl registry reshape2 restfulr Rhtslib rjson rlang rmarkdown rngtools rpart Rsamtools RSQLite rstudioapi rtracklayer S4Arrays S4Vectors S7 sass scales Seqinfo snow SparseArray stringi stringr SummarizedExperiment sys tinytex UCSC.utils VariantAnnotation vctrs viridisLite withr xfun XML XVector yaml

SomaticSignatures

Rendered fromSomaticSignatures-vignette.Rhtmlusingknitr::knitron Jun 10 2026.

Last update: 2025-07-22
Started: 2014-03-30

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Cluster Mutational Spectrum	cluster-spectrum clusterSpectrum
Decomposition Functions for Somatic Signatures	decomposition-signatures nmfDecomposition nmfSignatures pcaDecomposition pcaSignatures
GC Content	gcContent
GRanges converter functions	ncbi seqchar ucsc
Human Chromosome Names	hs-chrs hsAllosomes hsAutosomes hsLinear hsToplevel
Kmer Frequency	kmerFrequency
Kmer datasets	k3we k3wg kmers kmers-data
Group somatic moticfs	motifMatrix
Distributions of mutational locations.	mutationDistance plotRainfall
Normalize Somatic Motifs	mutational-normalization normalizeMotifs
Mutational Plots	mutational-plots plotVariantAbundance
Estimate Somatic Signatures	findSignatures identifySignatures mutational-signatures
'MutationalSignatures' class and methods	fitted fitted,MutationalSignatures-method MutationalSignatures MutationalSignatures-class observed observed,MutationalSignatures-method samples samples,MutationalSignatures-method show show,MutationalSignatures-method signatures signatures,MutationalSignatures-method
mutationContext functions	mutationContext mutationContextMutect
Number of Signatures	assessNumberSignatures plotNumberSignatures
readMutect	readMutect
SomaticCancerAlterations Results	sca-data sca_mm sca_motifs_tiny sca_sigs sigs_nmf sigs_pca
Plot Mutational Signatures	plotFittedSpectrum plotMutationSpectrum plotObservedSpectrum plotSampleMap plotSamples plotSignatureMap plotSignatures
21 Signatures	signatures21 signatures21-data
SomaticSignatures package	SomaticSignatures-package SomaticSignatures
Utility functions	dfConvertColumns variants-utils