Package: RVS 1.35.0

Introduction | Setting up Pedigree Data | Loading a Pedigree | Plotting a Pedigree | Calculating Sharing Probabilities | Sharing Probability for One Family, One Variant | P-Value for Multiple Families, One Variant | P-Value for Multiple Families, Multiple Variants | Correcting for Multiple Testing Using Potential P-values | Minor Allele Frequency Sensitivity Analysis | Related Founders Correction | Joint analysis of multiple variants | Enrichment Test | Gene-based analysis | Partial sharing test | Precomputing Sharing Probabilities and Number of Carriers for all Possible Carrier Subsets | Example of Analysis of the Rare Variants in the Genomic Sequence of a Gene | Appendix | Rare Variant Sharing Probability Assuming One Founder Introduces the Variant | Rare Variant Sharing Probabilities for a Subset of Affected Pedigree Members | Using Monte Carlo Simulation | Correcting for Related Founders | Computation of Approximate Correction Based on Kinship Coefficient | Estimating Mean Kinship Coefficient Among Founders | References