Package: ModCon 1.15.0

Johannes Ptok

ModCon: Modifying splice site usage by changing the mRNP code, while maintaining the genetic code

Collection of functions to calculate a nucleotide sequence surrounding for splice donors sites to either activate or repress donor usage. The proposed alternative nucleotide sequence encodes the same amino acid and could be applied e.g. in reporter systems to silence or activate cryptic splice donor sites.

Authors:Johannes Ptok [aut, cre]

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ModCon.pdf |ModCon.html
ModCon/json (API)
NEWS

# Install 'ModCon' in R:
install.packages('ModCon', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/caggtaagtat/modcon/issues

Datasets:
  • Codons - Table of codons and encoded amino acids
  • cds - CDS of firefly luciferase
  • hbg - Donor sequences and their HBS
  • hex - Hexamers and Z scores

On BioConductor:ModCon-1.15.0(bioc 3.21)ModCon-1.14.0(bioc 3.20)

functionalgenomicsalternativesplicing

4.00 score 1 stars 2 scripts 110 downloads 21 exports 1 dependencies

Last updated 3 months agofrom:b573fd3f61. Checks:7 OK. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKDec 29 2024
R-4.5-winOKDec 29 2024
R-4.5-linuxOKDec 29 2024
R-4.4-winOKDec 29 2024
R-4.4-macOKDec 29 2024
R-4.3-winOKDec 29 2024
R-4.3-macOKDec 29 2024

Exports:calculateHZEIintcalculateMaxEntScanScorechangeSequenceHZEICodonscreateCodonMatrixcreateFilialSequencePopulationdecreaseGTsiteStrengthdegradeSAsdegradeSDsgenerateRandomCodonsPerAAgetOverlappingVectorsFromVectorhbghexincreaseGTsiteStrengthModConmutatePopulationrecombineTwoSequencesselectBestAndMeanselectMatingIndividualsslidingWindowHZEImanipulationstartModConApp

Dependencies:data.table

Designing SD context with ModCon

Rendered fromModCon.Rmdusingknitr::rmarkdownon Dec 29 2024.

Last update: 2021-01-19
Started: 2020-10-21