Package: ModCon 1.15.0

Johannes Ptok

ModCon: Modifying splice site usage by changing the mRNP code, while maintaining the genetic code

Collection of functions to calculate a nucleotide sequence surrounding for splice donors sites to either activate or repress donor usage. The proposed alternative nucleotide sequence encodes the same amino acid and could be applied e.g. in reporter systems to silence or activate cryptic splice donor sites.

Authors:Johannes Ptok [aut, cre]

ModCon_1.15.0.tar.gz
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ModCon.pdf |ModCon.html
ModCon/json (API)
NEWS

# Install 'ModCon' in R:
install.packages('ModCon', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/caggtaagtat/modcon/issues

Datasets:
  • Codons - Table of codons and encoded amino acids
  • cds - CDS of firefly luciferase
  • hbg - Donor sequences and their HBS
  • hex - Hexamers and Z scores

On BioConductor:ModCon-1.15.0(bioc 3.21)ModCon-1.14.0(bioc 3.20)

functionalgenomicsalternativesplicing

4.00 score 1 stars 2 scripts 110 downloads 21 exports 1 dependencies

Last updated 2 months agofrom:b573fd3f61. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKNov 29 2024
R-4.5-winOKNov 29 2024
R-4.5-linuxOKNov 29 2024
R-4.4-winOKNov 29 2024
R-4.4-macOKNov 29 2024
R-4.3-winOKNov 29 2024
R-4.3-macOKNov 29 2024

Exports:calculateHZEIintcalculateMaxEntScanScorechangeSequenceHZEICodonscreateCodonMatrixcreateFilialSequencePopulationdecreaseGTsiteStrengthdegradeSAsdegradeSDsgenerateRandomCodonsPerAAgetOverlappingVectorsFromVectorhbghexincreaseGTsiteStrengthModConmutatePopulationrecombineTwoSequencesselectBestAndMeanselectMatingIndividualsslidingWindowHZEImanipulationstartModConApp

Dependencies:data.table

Designing SD context with ModCon

Rendered fromModCon.Rmdusingknitr::rmarkdownon Nov 29 2024.

Last update: 2021-01-19
Started: 2020-10-21