Package: ModCon 1.15.0

Johannes Ptok

ModCon: Modifying splice site usage by changing the mRNP code, while maintaining the genetic code

Collection of functions to calculate a nucleotide sequence surrounding for splice donors sites to either activate or repress donor usage. The proposed alternative nucleotide sequence encodes the same amino acid and could be applied e.g. in reporter systems to silence or activate cryptic splice donor sites.

Authors:Johannes Ptok [aut, cre]

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ModCon.pdf |ModCon.html
ModCon/json (API)
NEWS

# Install 'ModCon' in R:
install.packages('ModCon', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/caggtaagtat/modcon/issues

Datasets:
  • Codons - Table of codons and encoded amino acids
  • cds - CDS of firefly luciferase
  • hbg - Donor sequences and their HBS
  • hex - Hexamers and Z scores

On BioConductor:ModCon-1.15.0(bioc 3.21)ModCon-1.14.0(bioc 3.20)

functionalgenomicsalternativesplicing

4.00 score 1 stars 2 scripts 190 downloads 21 exports 1 dependencies

Last updated 5 months agofrom:b573fd3f61. Checks:8 OK. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKFeb 27 2025
R-4.5-winOKFeb 27 2025
R-4.5-macOKFeb 27 2025
R-4.5-linuxOKFeb 27 2025
R-4.4-winOKFeb 27 2025
R-4.4-macOKFeb 27 2025
R-4.3-winOKFeb 27 2025
R-4.3-macOKFeb 27 2025

Exports:calculateHZEIintcalculateMaxEntScanScorechangeSequenceHZEICodonscreateCodonMatrixcreateFilialSequencePopulationdecreaseGTsiteStrengthdegradeSAsdegradeSDsgenerateRandomCodonsPerAAgetOverlappingVectorsFromVectorhbghexincreaseGTsiteStrengthModConmutatePopulationrecombineTwoSequencesselectBestAndMeanselectMatingIndividualsslidingWindowHZEImanipulationstartModConApp

Dependencies:data.table

Designing SD context with ModCon

Rendered fromModCon.Rmdusingknitr::rmarkdownon Feb 27 2025.

Last update: 2021-01-19
Started: 2020-10-21