Package: ModCon 1.13.0

Johannes Ptok

ModCon: Modifying splice site usage by changing the mRNP code, while maintaining the genetic code

Collection of functions to calculate a nucleotide sequence surrounding for splice donors sites to either activate or repress donor usage. The proposed alternative nucleotide sequence encodes the same amino acid and could be applied e.g. in reporter systems to silence or activate cryptic splice donor sites.

Authors:Johannes Ptok [aut, cre]

ModCon_1.13.0.tar.gz
ModCon_1.13.0.zip(r-4.5)ModCon_1.13.0.zip(r-4.4)ModCon_1.13.0.zip(r-4.3)
ModCon_1.13.0.tgz(r-4.4-any)ModCon_1.13.0.tgz(r-4.3-any)
ModCon_1.13.0.tar.gz(r-4.5-noble)ModCon_1.13.0.tar.gz(r-4.4-noble)
ModCon_1.13.0.tgz(r-4.4-emscripten)ModCon_1.13.0.tgz(r-4.3-emscripten)
ModCon.pdf |ModCon.html
ModCon/json (API)
NEWS

# Install 'ModCon' in R:
install.packages('ModCon', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/caggtaagtat/modcon/issues

Datasets:
  • Codons - Table of codons and encoded amino acids
  • cds - CDS of firefly luciferase
  • hbg - Donor sequences and their HBS
  • hex - Hexamers and Z scores

On BioConductor:ModCon-1.13.0(bioc 3.20)ModCon-1.12.0(bioc 3.19)

functionalgenomicsalternativesplicing

21 exports 1 stars 4.00 score 1 dependencies 2 scripts 92 downloads

Last updated 5 months agofrom:eec00434c6. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKSep 15 2024
R-4.5-winOKSep 15 2024
R-4.5-linuxOKSep 15 2024
R-4.4-winOKSep 15 2024
R-4.4-macOKSep 15 2024
R-4.3-winOKSep 15 2024
R-4.3-macOKSep 15 2024

Exports:calculateHZEIintcalculateMaxEntScanScorechangeSequenceHZEICodonscreateCodonMatrixcreateFilialSequencePopulationdecreaseGTsiteStrengthdegradeSAsdegradeSDsgenerateRandomCodonsPerAAgetOverlappingVectorsFromVectorhbghexincreaseGTsiteStrengthModConmutatePopulationrecombineTwoSequencesselectBestAndMeanselectMatingIndividualsslidingWindowHZEImanipulationstartModConApp

Dependencies:data.table

Designing SD context with ModCon

Rendered fromModCon.Rmdusingknitr::rmarkdownon Sep 15 2024.

Last update: 2021-01-19
Started: 2020-10-21