Package: GDCRNATools 1.25.0

Ruidong Li

GDCRNATools: GDCRNATools: an R/Bioconductor package for integrative analysis of lncRNA, mRNA, and miRNA data in GDC

This is an easy-to-use package for downloading, organizing, and integrative analyzing RNA expression data in GDC with an emphasis on deciphering the lncRNA-mRNA related ceRNA regulatory network in cancer. Three databases of lncRNA-miRNA interactions including spongeScan, starBase, and miRcode, as well as three databases of mRNA-miRNA interactions including miRTarBase, starBase, and miRcode are incorporated into the package for ceRNAs network construction. limma, edgeR, and DESeq2 can be used to identify differentially expressed genes/miRNAs. Functional enrichment analyses including GO, KEGG, and DO can be performed based on the clusterProfiler and DO packages. Both univariate CoxPH and KM survival analyses of multiple genes can be implemented in the package. Besides some routine visualization functions such as volcano plot, bar plot, and KM plot, a few simply shiny apps are developed to facilitate visualization of results on a local webpage.

Authors:Ruidong Li, Han Qu, Shibo Wang, Julong Wei, Le Zhang, Renyuan Ma, Jianming Lu, Jianguo Zhu, Wei-De Zhong, Zhenyu Jia

GDCRNATools_1.25.0.tar.gz
GDCRNATools_1.25.0.zip(r-4.5)GDCRNATools_1.25.0.zip(r-4.4)GDCRNATools_1.25.0.zip(r-4.3)
GDCRNATools_1.25.0.tgz(r-4.4-any)GDCRNATools_1.25.0.tgz(r-4.3-any)
GDCRNATools_1.25.0.tar.gz(r-4.5-noble)GDCRNATools_1.25.0.tar.gz(r-4.4-noble)
GDCRNATools_1.25.0.tgz(r-4.4-emscripten)GDCRNATools_1.25.0.tgz(r-4.3-emscripten)
GDCRNATools.pdf |GDCRNATools.html
GDCRNATools/json (API)
NEWS

# Install 'GDCRNATools' in R:
install.packages('GDCRNATools', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • DEGAll - Output of 'gdcDEAnalysis' for downstream analysis
  • enrichOutput - Output of 'gdcEnrichAnalysis' for visualization
  • lncTarget - MiRNA-lncRNA interactions
  • mirCounts - MiRNA counts data of TCGA-CHOL
  • pcTarget - MiRNA-mRNA interactions
  • rnaCounts - RNAseq counts data of TCGA-CHOL

On BioConductor:GDCRNATools-1.25.0(bioc 3.20)GDCRNATools-1.24.0(bioc 3.19)

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

bioconductor-package

24 exports 1.08 score 216 dependencies 48 mentions

Last updated 2 months agofrom:fd0461c12e

Exports:gdcBarPlotgdcCEAnalysisgdcClinicalDownloadgdcClinicalMergegdcCorPlotgdcDEAnalysisgdcDEReportgdcEnrichAnalysisgdcEnrichPlotgdcExportNetworkgdcFilterDuplicategdcFilterSampleTypegdcHeatmapgdcKMPlotgdcMatchSamplesgdcParseMetadatagdcRNADownloadgdcRNAMergegdcSurvivalAnalysisgdcVolcanoPlotgdcVoomNormalizationshinyCorPlotshinyKMPlotshinyPathview

Dependencies:abindAnnotationDbiapeaplotaskpassbackportsbase64encBHBiobaseBiocFileCacheBiocGenericsBiocParallelbiomaRtBiostringsbitbit64bitopsblobbootbroombslibcachemcarcarDatacaToolsclicliprclusterProfilercodetoolscolorspacecommonmarkcorrplotcowplotcpp11crayoncrosstalkcurldata.tableDBIdbplyrDelayedArrayDESeq2digestDOSEdownloaderdplyrDTedgeRenrichplotevaluateexactRankTestsfansifarverfastmapfastmatchfgseafilelockfontawesomeformatRfsfutile.loggerfutile.optionsgenericsGenomeInfoDbGenomeInfoDbDataGenomicDataCommonsGenomicRangesggforceggfunggnewscaleggplot2ggplotifyggpubrggraphggrepelggsciggsignifggtextggtreeglueGO.dbGOSemSimgplotsgraphgraphlayoutsgridExtragridGraphicsgridtextgsongtablegtoolsHDO.dbhighrhmshtmltoolshtmlwidgetshttpuvhttrhttr2igraphIRangesisobandjpegjquerylibjsonliteKEGGgraphKEGGRESTKernSmoothkm.ciKMsurvknitrlabelinglambda.rlaterlatticelazyevallifecyclelimmalme4locfitmagrittrmarkdownMASSMatrixMatrixGenericsMatrixModelsmatrixStatsmaxstatmemoisemgcvmimeminqamunsellmvtnormnlmenloptrnnetnumDerivopensslorg.Hs.eg.dbpatchworkpathviewpbkrtestpillarpkgconfigplogrplyrpngpolyclippolynomprettyunitsprogresspromisespurrrquantregqvalueR6rappdirsRColorBrewerRcppRcppArmadilloRcppEigenRCurlreadrreshape2RgraphvizrjsonrlangrmarkdownRSQLiterstatixS4ArraysS4VectorssassscalesscatterpieshadowtextshinysnowsourcetoolsSparseArraySparseMstatmodstringistringrSummarizedExperimentsurvivalsurvminersurvMiscsyssystemfontstibbletidygraphtidyrtidyselecttidytreetinytextreeiotweenrtzdbUCSC.utilsutf8vctrsviridisviridisLitevroomwithrxfunXMLxml2xtableXVectoryamlyulab.utilszlibbioczoo

GDCRNATools: integrative analysis of protein coding genes, long non-coding genes, and microRNAs in GDC

Rendered fromindex.Rmdusingknitr::rmarkdownon Jun 21 2024.

Last update: 2017-12-01
Started: 2017-12-01

Readme and manuals

Help Manual

Help pageTopics
This is an easy-to-use package for downloading, organizing, and integrative analyzing RNA expression data in GDC with an emphasis on deciphering the lncRNA-mRNA related ceRNA regulatory network in cancer.GDCRNATools-package GDCRNATools
Output of 'gdcDEAnalysis' for downstream analysisDEGAll
Output of 'gdcEnrichAnalysis' for visualizationenrichOutput
Bar plot of differentially expressed genes/miRNAsgdcBarPlot
Competing endogenous RNAs (ceRNAs) analysisgdcCEAnalysis
Download clinical data in GDCgdcClinicalDownload
Merge clinical datagdcClinicalMerge
Correlation plot of two genes/miRNAsgdcCorPlot
Differential gene expression analysisgdcDEAnalysis
Report differentially expressed genes/miRNAsgdcDEReport
Functional enrichment analysisgdcEnrichAnalysis
Plots for enrichment analysisgdcEnrichPlot
Export network for CytoscapegdcExportNetwork
Filter out duplicated samplesgdcFilterDuplicate
Filter out other type of samplesgdcFilterSampleType
Heatmap of differentially expressed genes/miRNAsgdcHeatmap
Kaplan Meier plotgdcKMPlot
Match samples in metadata and expression matrixgdcMatchSamples
Parse metadatagdcParseMetadata
Download RNA data in GDCgdcRNADownload
Merge RNA/miRNAs raw counts datagdcRNAMerge
Univariate survival analysis of multiple genesgdcSurvivalAnalysis
Volcano plot of differentially expressed genes/miRNAsgdcVolcanoPlot
TMM normalization and voom transformationgdcVoomNormalization
miRNA-lncRNA interactionslncTarget
miRNA counts data of TCGA-CHOLmirCounts
miRNA-mRNA interactionspcTarget
RNAseq counts data of TCGA-CHOLrnaCounts
Shiny correlation plotshinyCorPlot
Shiny Kaplan Meier (KM) plotshinyKMPlot
Shiny pathviewshinyPathview