Package: DeMAND 1.43.0

Jung Hoon Woo

DeMAND: DeMAND

DEMAND predicts Drug MoA by interrogating a cell context specific regulatory network with a small number (N >= 6) of compound-induced gene expression signatures, to elucidate specific proteins whose interactions in the network is dysregulated by the compound.

Authors:Jung Hoon Woo <[email protected]>, Yishai Shimoni <[email protected]>

DeMAND_1.43.0.tar.gz
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DeMAND_1.43.0.tgz(r-4.6-any)DeMAND_1.43.0.tgz(r-4.5-any)
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DeMAND_1.43.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
DeMAND/json (API)

# Install 'DeMAND' in R:

install.packages('DeMAND', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Datasets:

bcellAnno - Annotation for the expression data
bcellExp - B cell expression data
bcellNetwork - B cell network
caseIndex - Case sample index
controlIndex - Control sample index

On BioConductor:DeMAND-1.43.0(bioc 3.24)DeMAND-1.42.0(bioc 3.23)

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

systemsbiology networkenrichment geneexpression statisticalmethod network

4.32 score 15 scripts 332 downloads 7 mentions 3 exports 1 dependencies

Last updated from:d7eee9f2d8. Checks:1 ERROR, 7 NOTE, 2 OK. Indexed: yes.

Target	Result	Time
bioc-checks	ERROR	145
linux-devel-x86_64	NOTE	129
source / vignettes	OK	172
linux-release-x86_64	NOTE	170
macos-release-arm64	NOTE	72
macos-oldrel-arm64	NOTE	106
windows-devel	NOTE	58
windows-release	NOTE	89
windows-oldrel	NOTE	79
wasm-release	OK	87

Exports:demandClass printDeMAND runDeMAND

Dependencies:KernSmooth

Using DeMAND

Rendered fromDeMAND.Rnwusingutils::Sweave

Last update: 2018-08-30
Started: 2015-03-27

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Annotation for the expression data	bcellAnno
B cell expression data	bcellExp
B cell network	bcellNetwork
Case sample index	caseIndex
Control sample index	controlIndex
The DeMAND instance	demand-instance
The demand class constructor	demandClass
Basic methods for class demand	printDeMAND
Run DeMAND algorithm	runDeMAND