Package: DOSE 4.7.0

Guangchuang Yu

DOSE: Disease Ontology Semantic and Enrichment analysis

This package implements five methods proposed by Resnik, Schlicker, Jiang, Lin and Wang respectively for measuring semantic similarities among DO terms and gene products. Enrichment analyses including hypergeometric model and gene set enrichment analysis are also implemented for discovering disease associations of high-throughput biological data.

Authors:Guangchuang Yu [aut, cre], Li-Gen Wang [ctb], Vladislav Petyuk [ctb], Giovanni Dall'Olio [ctb]

DOSE_4.7.0.tar.gz
DOSE_4.7.0.zip(r-4.7)DOSE_4.7.0.zip(r-4.6)DOSE_4.7.0.zip(r-4.5)
DOSE_4.7.0.tgz(r-4.6-any)DOSE_4.7.0.tgz(r-4.5-any)
DOSE_4.7.0.tar.gz(r-4.7-any)DOSE_4.7.0.tar.gz(r-4.6-any)
DOSE_4.7.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
DOSE/json (API)
NEWS

# Install 'DOSE' in R:
install.packages('DOSE', repos = c('https://bioc.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/guangchuangyu/dose/issues

Datasets:

On BioConductor:DOSE-4.7.0(bioc 3.24)DOSE-4.6.0(bioc 3.23)

annotationvisualizationmultiplecomparisongenesetenrichmentpathwayssoftwaredisease-ontologyenrichment-analysissemantic-similarity

15.24 score 126 stars 61 packages 3.3k scripts 43k downloads 138 mentions 17 exports 58 dependencies

Last updated from:0f4f367d08. Checks:8 ERROR, 2 OK. Indexed: yes.

TargetResultTimeFilesSyslog
bioc-checksERROR203
linux-devel-x86_64ERROR294
source / vignettesOK272
linux-release-x86_64ERROR282
macos-release-arm64ERROR161
macos-oldrel-arm64ERROR134
windows-develERROR201
windows-releaseERROR329
windows-oldrelERROR188
wasm-releaseOK157

Exports:clusterSimdoseSimdoSimenrichDGNenrichDGNvenrichDOenrichNCGfacet_gridgene2DOgeneSimget_organismgseDGNgseDOgseNCGmclusterSimsimplottheme_dose

Dependencies:AnnotationDbiaskpassBiobaseBiocGenericsBiostringsbitbit64blobcachemclicpp11crayoncurlDBIdigestenrichitfarverfastmapfsgenericsggplot2glueGO.dbGOSemSimgtablehttrIRangesisobandjsonliteKEGGRESTlabelinglifecyclemagrittrmemoisemimeopensslpkgconfigplyrpngR6rappdirsRColorBrewerRcppreshape2rlangRSQLiteS4VectorsS7scalesSeqinfostringistringrsysvctrsviridisLitewithrXVectoryulab.utils

DOSE: Disease Ontology Semantic and Enrichment analysis

Rendered fromDOSE.Rmdusingknitr::rmarkdownon May 29 2026.

Last update: 2020-09-09
Started: 2015-06-24

Readme and manuals

Help Manual

Help pageTopics
clusterSimclusterSim
compute information contentcomputeIC
DatasetsDataSet DGN_EXTID2PATHID DGN_PATHID2EXTID DGN_PATHID2NAME geneList NCG_EXTID2PATHID NCG_PATHID2EXTID NCG_PATHID2NAME VDGN_EXTID2PATHID VDGN_PATHID2EXTID VDGN_PATHID2NAME
Shared parameters for DOSE functionsdose_params
doseSimdoseSim doSim
Enrichment analysis based on the DisGeNET (<http://www.disgenet.org/>)enrichDGN
enrichDGNenrichDGNv
DO Enrichment AnalysisenrichDO
enrichNCGenrichNCG
convert Gene ID to DO Termsgene2DO
geneSimgeneSim
DisGeNET Gene Set Enrichment AnalysisgseDGN
DO Gene Set Enrichment AnalysisgseDO
NCG Gene Set Enrichment AnalysisgseNCG
mclusterSimmclusterSim
simplotsimplot
theme_dosetheme_dose