Package: vmrseq Type: Package Title: Probabilistic Modeling of Single-cell Methylation Heterogeneity Version: 1.5.1 Authors@R: c(person("Keegan", "Korthauer", , "kkorthauer@cmmt.ubc.ca", role = c("aut", "cre"), comment = c(ORCID = "0000-0002-4565-1654")), person("Ning", "Shen", , "ning.shen.wk@gmail.com", role = c("aut"), comment = c(ORCID = "0000-0002-2974-1086"))) Description: High-throughput single-cell measurements of DNA methylation allows studying inter-cellular epigenetic heterogeneity, but this task faces the challenges of sparsity and noise. We present vmrseq, a statistical method that overcomes these challenges and identifies variably methylated regions accurately and robustly. License: MIT + file LICENSE Encoding: UTF-8 RoxygenNote: 7.2.3 biocViews: Software, ImmunoOncology, DNAMethylation, Epigenetics, SingleCell, Sequencing, WholeGenome Depends: R (>= 4.5.0) Imports: bumphunter, dplyr, BiocParallel, DelayedArray, GenomicRanges, ggplot2, methods, tidyr, locfit, gamlss.dist, recommenderlab, HDF5Array, data.table, SummarizedExperiment, IRanges, S4Vectors, devtools Suggests: knitr, rmarkdown, testthat (>= 3.0.0) Config/testthat/edition: 3 VignetteBuilder: knitr URL: https://github.com/nshen7/vmrseq BugReports: https://github.com/nshen7/vmrseq/issues Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev libfribidi-dev git make libharfbuzz-dev libbz2-dev libgit2-dev libicu-dev libjpeg-dev liblzma-dev libpng-dev libtiff-dev libuv1-dev libwebp-dev libxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-08-06 19:18:23 UTC RemoteUrl: https://github.com/bioc/vmrseq RemoteRef: HEAD RemoteSha: f4be463ab3c3d9acee7fb97edc504937c6e1d11a NeedsCompilation: no Packaged: 2026-10-06 11:00:27 UTC; root Author: Keegan Korthauer [aut, cre] (ORCID: ), Ning Shen [aut] (ORCID: ) Maintainer: Keegan Korthauer