Changes in version 1.8.0                        

Features

    o   The Python implementation of profile creation has been deprecated

    o   SNV profiles are now stored as data frames, rather than GRanges objects

    o   The `create_profile` function now now reads profiles into memory, instead
	of storing them on disk. De-duplication and removal of mitochondrial
	variants is now also performed at this stage

    o   The `create_profiles` function now returns a list of data frames

    o   A new function, `write_profile`, can write profiles to disk

    o   The `read_profile` function now reads profiles without performing any
	de-duplication or removing mitochondrial chromosomes

    o   The `compare_profiles`, `compare_many` and `list_variants` functions now
	converts input profiles to GRanges internally

    o   Keep the FILTER column in created SNV profiles

    o   Add a check for the creation of zero-variant profiles

    o   Add a check for the existance of the specified input samples

    o   Removal of non-standard chromosomes and variant de-duplication is now
	optional, and filtration documentation has been extended

                        Changes in version 1.6.0                        

Features

    o   Make the variant caller-specific filtering optional (on by default) and
	rename the relevant parameter names for increased clarity

    o   Add a check to look for gVCF files as input, including the existance of
	<NON_REF> alleles (common for gVCF files)

    o   Add checks to see if input VCFs correctly contain DP, AD and GT data

                        Changes in version 1.4.0                        

Features

    o   Add convenience functions for creating and reading multiple SNV profiles

    o   Add functionality for reading general COSMIC mutational data, not just
	cell line mutational data

Fixes

    o   Fix an issue when reading COSMIC data due to new GRanges functionality

Miscellaneous

    o   Update the citation info with the now-published seqCAT-specific article

                        Changes in version 1.2.0                        

Features

    o   Add functionality for analysing VCF files containing unannotated variants

    o   Add functionality for listing non-overlapping variants between profiles

    o   Mitochondrial variants can now be optionally skipped when reading SNV
	profiles in the `read_variants` function

    o   Add the `list_variants` function for listing the genotypes of
	user-specified variants in each provided SNV profile

    o   Add the `plot_variant_list` function for plotting a genotype grid for
	each variant output by the `list_variants` function

Fixes

    o   Fix a multi-sample VCF profile creation issue (python only)

    o   Reading zero-variant profiles now properly returns a GRanges object with
	a dummy-variant profile containing the sample name

    o   Enable the `plot_impacts` function to properly analyse multi-impact SNVs

    o   Fix reading of SNV profiles containing single-quoted strings

                        Changes in version 1.0.0                        

Features

    o   Create single nucleotide variant (SNV) profiles from RNA/DNA-seq samples

    o   Characterise the biological equivalency and difference between samples

    o   Evaluate putative impacts of SNVs differing between samples

    o   Investigate and validate known variants and specific genomic regions

    o   Authenticate cell lines with a known SNV profile or the COSMIC database