Changes in version 0.99.3                        

Bug fixes

  - Improve overall stability.

                       Changes in version 0.99.2                        

Bug fixes

  - Improve overall stability.

                       Changes in version 0.99.1                        

Bug fixes

  - Removed inst/CITATION file lacking a DOI (Bioconductor BiocCheck
    WARNING).
  - Updated R version dependency from 4.5.0 to 4.6.0 to match
    Bioconductor 3.23.

                       Changes in version 0.99.0                        

New features

  - Initial release submitted to Bioconductor.
  - filterSparseDonors(): remove donors below a minimum cell count
    threshold per cell type before pseudo-bulk aggregation.
  - fastPseudobulk(): build donor-weighted pseudo-bulk profiles from a
    SingleCellExperiment using vectorised sparse matrix operations.
    Supports aggregation per donor (unpaired) or per donor × condition
    pair (paired).
  - fastDE(): run vectorised differential expression across all genes
    simultaneously using limma-voom with donor cell-count weights.
    Automatically detects paired designs (same donors in multiple
    conditions) and uses a ~ 0 + condition + donor blocking model.
  - plotDEResults(): volcano plot with significance colouring and
    top-gene labelling.
  - FDEResult S4 class for structured storage of DE results.