NEWS

scFastDE 0.99.3

Initial release submitted to Bioconductor.
filterSparseDonors(): remove donors below a minimum cell count threshold per cell type before pseudo-bulk aggregation.
fastPseudobulk(): build donor-weighted pseudo-bulk profiles from a SingleCellExperiment using vectorised sparse matrix operations. Supports aggregation per donor (unpaired) or per donor × condition pair (paired).
fastDE(): run vectorised differential expression across all genes simultaneously using limma-voom with donor cell-count weights. Automatically detects paired designs (same donors in multiple conditions) and uses a ~ 0 + condition + donor blocking model.
plotDEResults(): volcano plot with significance colouring and top-gene labelling.
FDEResult S4 class for structured storage of DE results.