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{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-83936","pathwayName":"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","pValue":7.68e-10,"pValueAdjusted":7.688e-07,"genes":"ARL2;SLC25A4;SLC29A1;SLC29A2","numCandidateGenes":4,"numBgGenes":1140,"geneRatio":0.00351,"totalGenes":2403,"topLevelPathway":"Transport small molecules"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-163841","pathwayName":"Gamma carboxylation, hypusine formation and arylsulfatase activation","pValue":8.208e-10,"pValueAdjusted":8.216e-07,"genes":"ARSK;DOHH;DPH1;DPH6;FN3KRP;SUMF2","numCandidateGenes":6,"numBgGenes":1140,"geneRatio":0.00526,"totalGenes":2403,"topLevelPathway":"Metabolism of proteins"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-446219","pathwayName":"Synthesis of substrates in N-glycan biosythesis","pValue":5.207e-09,"pValueAdjusted":5.212e-06,"genes":"AMDHD2;DOLK;FUOM;MPI;NUDT14;ST3GAL5;ST6GALNAC1","numCandidateGenes":7,"numBgGenes":1140,"geneRatio":0.00614,"totalGenes":2403,"topLevelPathway":"Metabolism of proteins"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-419408","pathwayName":"Lysosphingolipid and LPA receptors","pValue":3.418e-08,"pValueAdjusted":0.00003,"genes":"LPAR5;S1PR2;S1PR3;S1PR5","numCandidateGenes":4,"numBgGenes":1140,"geneRatio":0.00351,"totalGenes":2403,"topLevelPathway":"Signal Transduction"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-114452","pathwayName":"Activation of BH3-only proteins","pValue":3.78e-08,"pValueAdjusted":0.00004,"genes":"BBC3;BCL2;PPP1R13B;TP53;TP73","numCandidateGenes":5,"numBgGenes":1140,"geneRatio":0.00439,"totalGenes":2403,"topLevelPathway":"Programmed Cell Death"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-192105","pathwayName":"Synthesis of bile acids and bile salts","pValue":1.282e-07,"pValueAdjusted":0.00013,"genes":"CYP27A1;OSBPL3;OSBPL6;OSBPL7;SLC27A2","numCandidateGenes":5,"numBgGenes":1140,"geneRatio":0.00439,"totalGenes":2403,"topLevelPathway":"Metabolism"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-8939236","pathwayName":"RUNX1 regulates transcription of genes involved in differentiation of HSCs","pValue":3.027e-07,"pValueAdjusted":0.0003,"genes":"GATA2;GATA3;MYB;TCF3;TP73","numCandidateGenes":5,"numBgGenes":1140,"geneRatio":0.00439,"totalGenes":2403,"topLevelPathway":"Gene expression"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-216083","pathwayName":"Integrin cell surface interactions","pValue":4.755e-07,"pValueAdjusted":0.00048,"genes":"COL5A3;COL6A2;FN1;ICAM2;ITGA3;ITGB7;JAM3;MADCAM1;SPP1","numCandidateGenes":9,"numBgGenes":1140,"geneRatio":0.00789,"totalGenes":2403,"topLevelPathway":"ECM organization"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-202424","pathwayName":"Downstream TCR signaling","pValue":6.041e-07,"pValueAdjusted":0.0006,"genes":"CARD11;CD247;CD3D;CD3E;CD3G;CD4;HLA-DPA1;HLA-DPB1;HLA-DQB1;HLA-DQB2;HLA-DRA;HLA-DRB1;HLA-DRB5;LCK;PRKCQ;TRAT1","numCandidateGenes":16,"numBgGenes":1140,"geneRatio":0.01404,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-8851680","pathwayName":"Butyrophilin (BTN) family interactions","pValue":6.639e-07,"pValueAdjusted":0.00066,"genes":"BTN2A2;BTN3A2;BTN3A3","numCandidateGenes":3,"numBgGenes":1140,"geneRatio":0.00263,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Up","pathwayId":"R-HSA-156584","pathwayName":"Cytosolic sulfonation of small molecules","pValue":7.41e-07,"pValueAdjusted":0.00074,"genes":"ABHD14B;SLC35B2;SULT1A1;SULT1A2","numCandidateGenes":4,"numBgGenes":1140,"geneRatio":0.00351,"totalGenes":2403,"topLevelPathway":"Metabolism"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-6798695","pathwayName":"Neutrophil degranulation","pValue":0,"pValueAdjusted":0,"genes":"ACPP;ACTR2;ADGRG3;AGL;ALOX5;AMPD3;ARG1;ARPC5;ATP11A;ATP11B;BST1;C3AR1;CAB39;CAP1;CD177;CD44;CD55;CD58;CD59;CD63;CD93;CEACAM1;CKAP4;CLEC4D;CLEC5A;CR1;CTSC;CYSTM1;DNAJC13;FCAR;FCER1G;FGR;FPR2;GCA;GM2A;GNS;GPR84;GYG1;HK3;HP;IQGAP1;IQGAP2;LAIR1;LILRB3;LRG1;MAPK14;MCEMP1;MGAM;MMP8;MMP9;NCKAP1L;NDUFC2;NHLRC3;OSCAR;P2RX1;PADI2;PGM2;PLAC8;PTPRC;PYGL;QSOX1;RAB27A;RAB31;RAB3A;RETN;ROCK1;S100A12;S100A8;SERPINA1;SERPINB1;SIGLEC9;SIRPA;SLC2A3;SLCO4C1;STOM;TRPM2;VNN1","numCandidateGenes":77,"numBgGenes":822,"geneRatio":0.09367,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-9020702","pathwayName":"Interleukin-1 signaling","pValue":8.435e-24,"pValueAdjusted":8.443e-21,"genes":"CHUK;IL1B;IL1R1;IL1R2;IL1RAP;IL1RN;IRAK3;IRAK4;MAP2K6;MAP3K8;S100A12","numCandidateGenes":11,"numBgGenes":822,"geneRatio":0.01338,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-70221","pathwayName":"Glycogen breakdown (glycogenolysis)","pValue":6.984e-13,"pValueAdjusted":6.991e-10,"genes":"AGL;GYG1;PGM2;PHKA2;PYGL","numCandidateGenes":5,"numBgGenes":822,"geneRatio":0.00608,"totalGenes":2403,"topLevelPathway":"Metabolism"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-5621480","pathwayName":"Dectin-2 family","pValue":1.372e-09,"pValueAdjusted":1.373e-06,"genes":"CLEC4A;CLEC4D;CLEC6A;FCER1G;LYN","numCandidateGenes":5,"numBgGenes":822,"geneRatio":0.00608,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-446652","pathwayName":"Interleukin-1 family signaling","pValue":2.143e-08,"pValueAdjusted":0.00002,"genes":"ALOX5;CHUK;IL18R1;IL18RAP;IL1B;IL1R1;IL1R2;IL1RAP;IL1RN;IRAK3;IRAK4;MAP2K6;MAP3K8;PTPN12;PTPN2;S100A12","numCandidateGenes":16,"numBgGenes":822,"geneRatio":0.01946,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-198933","pathwayName":"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","pValue":6.612e-08,"pValueAdjusted":0.00007,"genes":"CD300LD;CD300LF;ICAM5;LAIR1;LILRA5;LILRB3;NECTIN2;OSCAR;PVRL2;SIGLEC10;SIGLEC12;SIGLEC7;SIGLEC9","numCandidateGenes":13,"numBgGenes":822,"geneRatio":0.01582,"totalGenes":2403,"topLevelPathway":"Immune System"}
{"comparison":"COVID Neg Over Time","direction":"Down","pathwayId":"R-HSA-2160916","pathwayName":"Hyaluronan uptake and degradation","pValue":2.48e-07,"pValueAdjusted":0.00025,"genes":"CD44;HYAL2;LYVE1","numCandidateGenes":3,"numBgGenes":822,"geneRatio":0.00365,"totalGenes":2403,"topLevelPathway":"Metabolism"}