Package: nipalsMCIA Title: Multiple Co-Inertia Analysis via the NIPALS Method Version: 1.11.0 Authors@R: c( person("Maximilian", "Mattessich", email = "maximilian.mattessich@northwestern.edu", role = "cre", comment = c(ORCID = "0000-0002-1233-1240")), person("Joaquin", "Reyna", email = "joreyna@live.com", role = "aut", comment = c(ORCID = "0000-0002-8468-2840")), person("Edel", "Aron", email = "edel.aron@yale.edu", role = "aut", comment = c(ORCID = "0000-0002-8683-4772")), person("Ferhat", "Ay", email = "ferhatay@lji.org", role = "aut", comment = c(ORCID = "0000-0002-0708-6914")), person("Steven", "Kleinstein", email = "steven.kleinstein@yale.edu", role = "aut", comment = c(ORCID = "0000-0003-4957-1544")), person("Anna", "Konstorum", email = "konstorum.anna@gmail.com", role = "aut", comment = c(ORCID = "0000-0003-4024-2058"))) Description: Computes Multiple Co-Inertia Analysis (MCIA), a dimensionality reduction (jDR) algorithm, for a multi-block dataset using a modification to the Nonlinear Iterative Partial Least Squares method (NIPALS) proposed in (Hanafi et. al, 2010). Allows multiple options for row- and table-level preprocessing, and speeds up computation of variance explained. Vignettes detail application to bulk- and single cell- multi-omics studies. License: GPL-3 URL: https://github.com/Muunraker/nipalsMCIA BugReports: https://github.com/Muunraker/nipalsMCIA/issues Depends: R (>= 4.3.0) Imports: ComplexHeatmap, dplyr, fgsea, ggplot2 (>= 3.0.0), graphics, grid, methods, MultiAssayExperiment, SummarizedExperiment, pracma, rlang, RSpectra, scales, stats Suggests: BiocFileCache, BiocStyle, circlize, ggpubr, KernSmooth, knitr, piggyback, reshape2, rmarkdown, rpart, Seurat (>= 4.0.0), spatstat.explore, stringr, survival, tidyverse, testthat (>= 3.0.0) VignetteBuilder: knitr biocViews: Software, Clustering, Classification, MultipleComparison, Normalization, Preprocessing, SingleCell Encoding: UTF-8 RoxygenNote: 7.3.2 Config/testthat/edition: 3 Config/pak/sysreqs: libicu-dev libpng-dev perl zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 13:01:33 UTC RemoteUrl: https://github.com/bioc/nipalsMCIA RemoteRef: HEAD RemoteSha: e4c24cee0df32d41e2b3cca1c4f283b169d4a939 NeedsCompilation: no Packaged: 2026-07-04 16:25:27 UTC; root Author: Maximilian Mattessich [cre] (ORCID: ), Joaquin Reyna [aut] (ORCID: ), Edel Aron [aut] (ORCID: ), Ferhat Ay [aut] (ORCID: ), Steven Kleinstein [aut] (ORCID: ), Anna Konstorum [aut] (ORCID: ) Maintainer: Maximilian Mattessich