Package: mslp
Type: Package
Title: Predict synthetic lethal partners of tumour mutations
Version: 1.15.0
Authors@R: person(given = "Chunxuan", family = "Shao", role = c("aut", "cre"), email = "chunxuan@outlook.com")
Description: An integrated pipeline to predict the potential synthetic
        lethality partners (SLPs) of tumour mutations, based on gene
        expression, mutation profiling and cell line genetic screens
        data. It has builtd-in support for data from cBioPortal. The
        primary SLPs correlating with muations in WT and compensating
        for the loss of function of mutations are predicted by random
        forest based methods (GENIE3) and Rank Products, respectively.
        Genetic screens are employed to identfy consensus SLPs leads to
        reduced cell viability when perturbed.
License: GPL-3
Encoding: UTF-8
LazyData: false
RoxygenNote: 7.2.3
Depends: R (>= 4.2.0)
Imports: data.table (>= 1.13.0), doRNG, fmsb, foreach, magrittr,
        org.Hs.eg.db, pROC, randomForest, RankProd, stats, utils
Suggests: BiocStyle, doFuture, future, knitr, rmarkdown, roxygen2,
        tinytest
VignetteBuilder: knitr
biocViews: Pharmacogenetics, Pharmacogenomics
Config/pak/sysreqs: libgmp3-dev libpng-dev libmpfr-dev libssl-dev
        zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2026-04-28 12:58:37 UTC
RemoteUrl: https://github.com/bioc/mslp
RemoteRef: HEAD
RemoteSha: 6b44cd84c33c4c8544cba99c3b51849d92693140
NeedsCompilation: no
Packaged: 2026-07-04 01:30:24 UTC; root
Author: Chunxuan Shao [aut, cre]
Maintainer: Chunxuan Shao <chunxuan@outlook.com>