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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "motifbreakR" in publications use:'
type: software
license: GPL-2.0-only
title: 'motifbreakR: A Package For Predicting The Disruptiveness Of Single Nucleotide
  Polymorphisms On Transcription Factor Binding Sites'
version: 2.19.0
doi: 10.1093/bioinformatics/btv470
abstract: We introduce motifbreakR, which allows the biologist to judge in the first
  place whether the sequence surrounding the polymorphism is a good match, and in
  the second place how much information is gained or lost in one allele of the polymorphism
  relative to another. MotifbreakR is both flexible and extensible over previous offerings;
  giving a choice of algorithms for interrogation of genomes with motifs from public
  sources that users can choose from; these are 1) a weighted-sum probability matrix,
  2) log-probabilities, and 3) weighted by relative entropy. MotifbreakR can predict
  effects for novel or previously described variants in public databases, making it
  suitable for tasks beyond the scope of its original design. Lastly, it can be used
  to interrogate any genome curated within Bioconductor (currently there are 32 species,
  a total of 109 versions).
authors:
- family-names: Coetzee
  given-names: Simon Gert
  email: simon.coetzee@cshs.org
- family-names: Hazelett
  given-names: Dennis J.
  email: dennis.hazelett@cshs.org
preferred-citation:
  type: article
  title: 'motifbreakR: an R/Bioconductor package for predicting variant effects at
    transcription factor binding sites'
  authors:
  - family-names: Coetzee
    given-names: Simon G.
  - family-names: Coetzee
    given-names: Gerhard A.
  - family-names: Hazelett
    given-names: Dennis J.
    email: dennis.hazelett@cshs.org
  year: '2015'
  journal: Bioinformatics
  doi: 10.1093/bioinformatics/btv470
  url: http://bioinformatics.oxfordjournals.org/content/early/2015/08/12/bioinformatics.btv470.abstract
repository: https://bioc.r-universe.dev
repository-code: https://github.com/Simon-Coetzee/motifbreakR
url: https://github.com/Simon-Coetzee/motifbreakR
contact:
- family-names: Coetzee
  given-names: Simon Gert
  email: simon.coetzee@cshs.org