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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "methodical" in publications use:'
type: software
license: GPL-3.0-or-later
title: 'methodical: Discovering genomic regions where methylation is strongly associated
  with transcriptional activity'
version: 1.1.0
abstract: DNA methylation is generally considered to be associated with transcriptional
  silencing. However, comprehensive, genome-wide investigation of this relationship
  requires the evaluation of potentially millions of correlation values between the
  methylation of individual genomic loci and expression of associated transcripts
  in a relatively large numbers of samples. Methodical makes this process quick and
  easy while keeping a low memory footprint. It also provides a novel method for identifying
  regions where a number of methylation sites are consistently strongly associated
  with transcriptional expression. In addition, Methodical enables housing DNA methylation
  data from diverse sources (e.g. WGBS, RRBS and methylation arrays) with a common
  framework, lifting over DNA methylation data between different genome builds and
  creating base-resolution plots of the association between DNA methylation and transcriptional
  activity at transcriptional start sites.
authors:
- family-names: Heery
  given-names: Richard
  email: richardheery@gmail.com
  orcid: https://orcid.org/0000-0001-8067-3114
repository: https://bioc.r-universe.dev
repository-code: https://github.com/richardheery/methodical
url: https://github.com/richardheery/methodical
contact:
- family-names: Heery
  given-names: Richard
  email: richardheery@gmail.com
  orcid: https://orcid.org/0000-0001-8067-3114