Changes in version 1.7.2 (2020-12-17) o Removed support for NCIS normalization, which relied on a now deprecated package. Changes in version 1.3.3 (2019-11-13) o Fixed a bug which caused overlapping contiguous regions to be assigned the wrong coverage values. Changes in version 1.3.1 (2019-11-05) o Added the metagene2_heatmap function, which generates heatmap representation of the binned coverages underlying the metagene2 object. Changes in version 1.1.4 (2019-07-12) o Improved documentation of control samples in design. Changes in version 1.1.3 (2019-05-13) o When parameter validation fails, the metagene2 object will now fall back to the previous set of parameters, instead of ending up in an invalid state. Changes in version 1.1.2 (2019-05-09) o rnaseq mode now sets strand_specific to TRUE by default. Changes in version 1.1.1 (2019-05-03) o Added log2_ratio normalization option. o Fix a bug that prevented strand_specific and stitch mode to work together. Changes in version 1.1.0 (2019-04-05) o Submitted package to Bioconductor.