NEWS

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iModMix 1.0.0

• **Initial Release** - Introduction of 'iModMix', a novel network-based approach that integrates multi-omics data, including metabolomics, proteomics, and transcriptomics data. - Ability to incorporate both identified and unidentified metabolites. - Functions for loading and preprocessing data, performing partial correlation analysis, hierarchical clustering, and module eigengene calculation. - Integration of multiple omics datasets to reveal significant associations with phenotypes of interest. - Visualization tools for dendrograms, module assignments, and network plots. - Enrichment analysis using gene symbols with support for various databases. Key Features - 'load_data()': Function to load and preprocess expression data. - 'partial_cors()': Function to perform partial correlation analysis using Graphical Lasso. - 'hierarchical_cluster()': Function to perform hierarchical clustering using TOM or partial correlation matrix. - 'cluster_assignments()': Function to assign clusters to features based on hierarchical clustering. - 'Eigengenes()': Function to calculate module eigengenes. - 'perform_classification()': Function to relate modules to phenotypes using statistical analysis. - 'Modules_correlation()': Function to integrate multiple omics datasets and calculate correlations. - 'Assigment_genes_enrichr()': Function to perform enrichment analysis using gene symbols. - Created documentation and examples for the functions. - Added vignette to demonstrate the usage of the package.