# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "fRagmentomics" in publications use:' type: software license: GPL-3.0-or-later title: 'fRagmentomics: Extract Fragmentomics Features and Mutational Status' version: 1.1.0 doi: 10.32614/CRAN.package.fRagmentomics abstract: A user-friendly R package that enables the characterization of each cfDNA fragment overlapping one or multiple mutations of interest, starting from a sequencing file containing aligned reads (BAM file). fRagmentomics supports multiple mutation input formats (e.g., VCF, TSV, or string "chr:pos:ref:alt" representation), accommodates one-based and zero-based genomic conventions, handles mutation representation ambiguities, and accepts any reference file and species in FASTA format. For each cfDNA fragment, fRagmentomics outputs its size, its 3' and 5' sequences, and its mutational status. Optionally, when users set apply_bcftools_norm = TRUE, fRagmentomics invokes the external command-line tool bcftools norm to left-align and normalize variants. If bcftools is not found on the system PATH while this option is enabled, the function errors. The package does not install external software; see the INSTALL file for per-OS instructions. authors: - family-names: Maudet given-names: Killian email: killian.maudet@gustaveroussy.fr orcid: https://orcid.org/0009-0003-3237-092X - family-names: Samaniego given-names: Juliette email: juliette.samaniego@gustaveroussy.fr orcid: https://orcid.org/0009-0002-3421-1810 - family-names: Pradat given-names: Yoann email: yoann.pradat@gustaveroussy.fr orcid: https://orcid.org/0000-0002-4647-5779 - family-names: Bernard given-names: Elsa email: elsa.bernard@gustaveroussy.fr orcid: https://orcid.org/0000-0002-2057-7187 repository: https://bioc.r-universe.dev repository-code: https://github.com/ElsaB-Lab/fRagmentomics commit: 69857f385283d4d00554d0824eecea2cf6cb5659 url: https://github.com/ElsaB-Lab/fRagmentomics date-released: '2026-04-28' contact: - family-names: Maudet given-names: Killian email: killian.maudet@gustaveroussy.fr orcid: https://orcid.org/0009-0003-3237-092X