Changes in version 1.3.1 (2018-11-02)                  

    o   dmrseq now requires that input BSseq objects be ordered (as the BSseq() 
	constructor no longer automatically orders loci).

                 Changes in version 1.1.20 (2018-10-11)                 

    o   Minor bug fix for a rare situation that occured in the case of a multi-level 
	covariate of interest if the region level model fitting procedure did not 
	converge.

                 Changes in version 1.1.2 (2018-05-09)                  

    o   The newly added `chrsPerChunk` argument specifies the number of chromosomes
	to compute at a time (default is 1). 

                Changes in version 0.99.11 (2018-04-05)                 

    o   dmrseq now provides support for detecting large-scale methylation blocks. To
	use this feature, specify `block=TRUE`, and increase the smoothing span 
	parameters `minInSpan`, `bpSpan`, and `maxGapSmooth`. More details are 
	provided in the documentation and vignette.

                 Changes in version 0.99.8 (2018-03-21)                 

    o   dmrseq no longer requires balanced, two-group comparisons. To run using a 
	continuous or categorial covariate with more than two groups, simply pass in
	the name of a column in `pData` that contains this covariate. A continuous
	covariate is assmued if the data type in the `testCovariate` slot is 
	continuous, with the exception of if there are only two unique values (then a
	two group comparison is carried out).

                 Changes in version 0.99.6 (2018-03-02)                 

    o   dmrseq is now available on Bioconductor devel (3.7) !