NEWS

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dmrseq 1.3.1 (2018-11-02)

• dmrseq now requires that input BSseq objects be ordered (as the BSseq() constructor no longer automatically orders loci).

dmrseq 1.1.20 (2018-10-11)

• Minor bug fix for a rare situation that occured in the case of a multi-level covariate of interest if the region level model fitting procedure did not converge.

dmrseq 1.1.2 (2018-05-09)

• The newly added 'chrsPerChunk' argument specifies the number of chromosomes to compute at a time (default is 1).

dmrseq 0.99.11 (2018-04-05)

• dmrseq now provides support for detecting large-scale methylation blocks. To use this feature, specify 'block=TRUE', and increase the smoothing span parameters 'minInSpan', 'bpSpan', and 'maxGapSmooth'. More details are provided in the documentation and vignette.

dmrseq 0.99.8 (2018-03-21)

• dmrseq no longer requires balanced, two-group comparisons. To run using a continuous or categorial covariate with more than two groups, simply pass in the name of a column in 'pData' that contains this covariate. A continuous covariate is assmued if the data type in the 'testCovariate' slot is continuous, with the exception of if there are only two unique values (then a two group comparison is carried out).

dmrseq 0.99.6 (2018-03-02)

• dmrseq is now available on Bioconductor devel (3.7) !