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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "crisprDesign" in publications use:'
type: software
license: MIT
title: 'crisprDesign: Comprehensive design of CRISPR gRNAs for nucleases and base
  editors'
version: 1.7.2
abstract: 'Provides a comprehensive suite of functions to design and annotate CRISPR
  guide RNA (gRNAs) sequences. This includes on- and off-target search, on-target
  efficiency scoring, off-target scoring, full gene and TSS contextual annotations,
  and SNP annotation (human only). It currently support five types of CRISPR modalities
  (modes of perturbations): CRISPR knockout, CRISPR activation, CRISPR inhibition,
  CRISPR base editing, and CRISPR knockdown. All types of CRISPR nucleases are supported,
  including DNA- and RNA-target nucleases such as Cas9, Cas12a, and Cas13d. All types
  of base editors are also supported. gRNA design can be performed on reference genomes,
  transcriptomes, and custom DNA and RNA sequences. Both unpaired and paired gRNA
  designs are enabled.'
authors:
- family-names: Fortin
  given-names: Jean-Philippe
  email: fortin946@gmail.com
- family-names: Hoberecht
  given-names: Luke
  email: lukehob3@gmail.com
preferred-citation:
  type: article
  title: A comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs
    across nucleases and technologies
  authors:
  - family-names: Hoberecht
    given-names: Luke
    email: lukehob3@gmail.com
  - family-names: Perampalam
    given-names: Pirunthan
  - family-names: Lun
    given-names: Aaron
  - family-names: Fortin
    given-names: Jean-Philippe
    email: fortin946@gmail.com
  journal: Nature Communications
  volume: '13'
  issue: '1'
  year: '2022'
  start: '6568'
repository: https://bioc.r-universe.dev
repository-code: https://github.com/crisprVerse/crisprDesign
url: https://github.com/crisprVerse/crisprDesign
contact:
- family-names: Fortin
  given-names: Jean-Philippe
  email: fortin946@gmail.com