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cff-version: 1.2.0
message: 'To cite package "compSPOT" in publications use:'
type: software
license: Artistic-2.0
title: 'compSPOT: compSPOT: Tool for identifying and comparing significantly mutated
  genomic hotspots'
version: 1.3.0
abstract: Clonal cell groups share common mutations within cancer, precancer, and
  even clinically normal appearing tissues. The frequency and location of these mutations
  may predict prognosis and cancer risk. It has also been well established that certain
  genomic regions have increased sensitivity to acquiring mutations. Mutation-sensitive
  genomic regions may therefore serve as markers for predicting cancer risk. This
  package contains multiple functions to establish significantly mutated hotspots,
  compare hotspot mutation burden between samples, and perform exploratory data analysis
  of the correlation between hotspot mutation burden and personal risk factors for
  cancer, such as age, gender, and history of carcinogen exposure. This package allows
  users to identify robust genomic markers to help establish cancer risk.
authors:
- family-names: Grant
  given-names: Sydney
  email: Sydney.Grant@roswellpark.org
  orcid: https://orcid.org/0000-0003-1849-5921
- family-names: Sampson
  given-names: Ella
  email: ellasamp@buffalo.edu
- family-names: Rodrigues
  given-names: Rhea
  email: RheaCarmelGlen.Rodrigues@roswellpark.org
  orcid: https://orcid.org/0000-0002-8573-8658
- family-names: Paragh
  given-names: Gyorgy
  email: Gyorgy.Paragh@roswellpark.org
  orcid: https://orcid.org/0000-0002-6612-9267
repository: https://bioc.r-universe.dev
repository-code: https://github.com/sydney-grant/compSPOT
url: https://github.com/sydney-grant/compSPOT
contact:
- family-names: Grant
  given-names: Sydney
  email: Sydney.Grant@roswellpark.org
  orcid: https://orcid.org/0000-0003-1849-5921