Package: clipper Version: 1.53.0 Date: 2019-04-09 Title: Gene Set Analysis Exploiting Pathway Topology Author: Paolo Martini , Gabriele Sales , Chiara Romualdi Maintainer: Paolo Martini Description: Implements topological gene set analysis using a two-step empirical approach. It exploits graph decomposition theory to create a junction tree and reconstruct the most relevant signal path. In the first step clipper selects significant pathways according to statistical tests on the means and the concentration matrices of the graphs derived from pathway topologies. Then, it "clips" the whole pathway identifying the signal paths having the greatest association with a specific phenotype. Depends: R (>= 2.15.0), Matrix, graph Imports: methods, Biobase, Rcpp, igraph, gRbase (>= 1.6.6), qpgraph, KEGGgraph, corpcor Suggests: RUnit, BiocGenerics, graphite, ALL, hgu95av2.db, MASS, BiocStyle Enhances: RCy3 License: AGPL-3 Config/pak/sysreqs: libglpk-dev make libbz2-dev liblzma-dev libpng-dev libxml2-dev libssl-dev xz-utils zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:37:15 UTC RemoteUrl: https://github.com/bioc/clipper RemoteRef: HEAD RemoteSha: 19b96ff090ebfbad067ecf6ca0539c773994441f NeedsCompilation: no Packaged: 2026-07-03 06:19:02 UTC; root