Changes in version 0.99.5 - Vignette: how the package fits into Bioconductor and how it differs from related packages. Changes in version 0.99.4 - Removed a stray copy of the package from a subfolder. Changes in version 0.99.3 - Pairs holding only an R2 (non-descendant) relation are tested again in later sweeps; R2 in both directions makes a pair unrelated (symmetry). Changes in version 0.99.2 - README wording. Changes in version 0.99.1 - SummarizedExperiment is now imported (Bioconductor dependency). - simulateTwoTier() no longer calls set.seed(); call it before simulating. - Labelled vignette chunks, 4-space indentation, no suppressWarnings(). Changes in version 0.99.0 - Initial Bioconductor submission. - ascend() for matrices, data frames and SummarizedExperiment objects; ascendMultiAssay() for MultiAssayExperiment objects. - AscendResult class with ancestralMatrix(), ancestralEdges(), pairPValues() and ascendStats(). - simulateTwoTier(), trueAncestral() and evaluateAncestral() for simulation and benchmarking. - Results are identical to the implementation used in the paper.