Please cite the following works when using the 'biotmle' software package, including both the software tool and the article describing the statistical methodology.

Hejazi NS, van der Laan MJ, Hubbard AE (2026). biotmle: Targeted Learning with moderated statistics for biomarker discovery. doi:10.18129/B9.bioc.biotmle. R package version 1.37.0, https://bioconductor.org/packages/biotmle.

Hejazi NS, Cai W, Hubbard AE (2017). “biotmle: Targeted Learning for Biomarker Discovery.” The Journal of Open Source Software. doi:10.21105/joss.00295. https://doi.org/10.21105/joss.00295.

Hejazi NS, Boileau P, van der Laan MJ, Hubbard AE (2021). “A generalization of moderated statistics to data adaptive semiparametric estimation in high-dimensional biology.” arxiv. https://arxiv.org/abs/1710.05451.

Corresponding BibTeX entries:

  @Manual{,
    title = {{biotmle}: Targeted Learning with moderated statistics for
      biomarker discovery},
    author = {Nima S Hejazi and Mark J {van der Laan} and Alan E
      Hubbard},
    year = {2026},
    note = {R package version 1.37.0},
    doi = {10.18129/B9.bioc.biotmle},
    url = {https://bioconductor.org/packages/biotmle},
  }

  @Article{,
    journal = {The Journal of Open Source Software},
    title = {biotmle: Targeted Learning for Biomarker Discovery},
    author = {Nima S Hejazi and Weixin Cai and Alan E Hubbard},
    year = {2017},
    doi = {10.21105/joss.00295},
    url = {https://doi.org/10.21105/joss.00295},
  }

  @Article{,
    journal = {arxiv},
    title = {A generalization of moderated statistics to data adaptive
      semiparametric estimation in high-dimensional biology},
    author = {Nima S Hejazi and Philippe Boileau and Mark J {van der
      Laan} and Alan E Hubbard},
    year = {2021},
    url = {https://arxiv.org/abs/1710.05451},
  }