Package: awst Title: Asymmetric Within-Sample Transformation Version: 1.21.0 Authors@R: c(person(given = "Davide", family = "Risso", role = c("aut", "cre", "cph"), email = "risso.davide@gmail.com", comment = c(ORCID = "0000-0001-8508-5012")), person(given = "Stefano", family = "Pagnotta", role = c("aut", "cph"), email = "smpagnotta@gmail.com", comment = c(ORCID = "0000-0002-8298-9777"))) Description: We propose an Asymmetric Within-Sample Transformation (AWST) to regularize RNA-seq read counts and reduce the effect of noise on the classification of samples. AWST comprises two main steps: standardization and smoothing. These steps transform gene expression data to reduce the noise of the lowly expressed features, which suffer from background effects and low signal-to-noise ratio, and the influence of the highly expressed features, which may be the result of amplification bias and other experimental artifacts. License: MIT + file LICENSE Encoding: UTF-8 RoxygenNote: 7.1.1 URL: https://github.com/drisso/awst BugReports: https://github.com/drisso/awst/issues Imports: stats, methods, SummarizedExperiment Suggests: airway, ggplot2, testthat, EDASeq, knitr, BiocStyle, RefManageR, sessioninfo, rmarkdown biocViews: Normalization, GeneExpression, RNASeq, Software, Transcriptomics, Sequencing, SingleCell VignetteBuilder: knitr Config/pak/sysreqs: zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:55:53 UTC RemoteUrl: https://github.com/bioc/awst RemoteRef: HEAD RemoteSha: c693f862908ad025a3a1220f0a0528293bf25006 NeedsCompilation: no Packaged: 2026-06-21 09:13:33 UTC; root Author: Davide Risso [aut, cre, cph] (ORCID: ), Stefano Pagnotta [aut, cph] (ORCID: ) Maintainer: Davide Risso