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  "Package": "topGO",
  "Type": "Package",
  "Title": "Enrichment Analysis for Gene Ontology",
  "Version": "2.65.0",
  "Date": "2025-06-23",
  "Authors@R": "c(\nperson(\ngiven = \"Adrian\", family = \"Alexa\", role = c(\"aut\"),\nemail = \"adrian.alexa@gmail.com\"\n),\nperson(\ngiven = \"Jörg\", family = \"Rahnenführer\", role = c(\"aut\")\n),\nperson(\ngiven = \"Federico\", family = \"Marini\", role = c(\"cre\"),\nemail = \"marinif@uni-mainz.de\", comment = c(ORCID = \"0000-0003-3252-7758\")\n)\n)",
  "Description": "topGO package provides tools for testing GO terms while\naccounting for the topology of the GO graph. Different test\nstatistics and different methods for eliminating local\nsimilarities and dependencies between GO terms can be\nimplemented and applied.",
  "License": "LGPL",
  "Encoding": "UTF-8",
  "Collate": "AllClasses.R topGOmethods.R topGOgraph.R topGOalgo.R\ntopGOfunctions.R topGOannotations.R topGOtests.R topGOviz.R\nzzz.R",
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  "biocViews": "GeneExpression, Transcriptomics, GeneSetEnrichment, GO,\nAnnotation, Pathways, SystemsBiology, Microarray, Sequencing,\nVisualization, Software",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:32:13 UTC",
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  "NeedsCompilation": "no",
  "Packaged": {
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    "User": "root"
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  "Author": "Adrian Alexa [aut],\nJörg Rahnenführer [aut],\nFederico Marini [cre] (ORCID: <https://orcid.org/0000-0003-3252-7758>)",
  "Maintainer": "Federico Marini <marinif@uni-mainz.de>",
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  "_created": "2026-11-01T12:55:36.000Z",
  "_published": "2026-11-01T13:53:57.041Z",
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    "annFUN.file",
    "annFUN.gene2GO",
    "annFUN.GO2genes",
    "annFUN.org",
    "attrInTerm",
    "buildLevels",
    "combineResults",
    "contTable",
    "countGenesInTerm",
    "cutOff",
    "cutOff<-",
    "depth",
    "depth<-",
    "description",
    "description<-",
    "elim",
    "elim<-",
    "expressionMatrix",
    "feasible",
    "feasible<-",
    "geneData",
    "geneData<-",
    "genes",
    "geneScore",
    "geneSelectionFun",
    "geneSelectionFun<-",
    "genesInTerm",
    "GenTable",
    "getGraphRoot",
    "getNoOfLevels",
    "getPvalues",
    "getSigGroups",
    "getSigRatio",
    "GOFisherTest",
    "GOglobalTest",
    "GOKSTest",
    "GOKSTiesTest",
    "GOplot",
    "GOSumTest",
    "GOtTest",
    "graph",
    "graph<-",
    "groupGOTerms",
    "inducedGraph",
    "initialize",
    "inverseList",
    "joinFun",
    "members",
    "members<-",
    "membersExpr",
    "membersScore",
    "Name",
    "Name<-",
    "nodesInInducedGraph",
    "numAllMembers",
    "numGenes",
    "numMembers",
    "numSigAll",
    "numSigGenes",
    "numSigMembers",
    "ontology",
    "ontology<-",
    "penalise",
    "permSumStats",
    "permSumStats.all",
    "phenotype",
    "print",
    "printGenes",
    "printGraph",
    "pType",
    "pType<-",
    "rankMembers",
    "readMappings",
    "reverseArch",
    "runTest",
    "score",
    "score<-",
    "scoreOrder",
    "scoresInTerm",
    "show",
    "showGroupDensity",
    "showSigOfNodes",
    "sigAllMembers",
    "sigGenes",
    "sigMembers",
    "sigMembers<-",
    "sigRatio<-",
    "termStat",
    "testName",
    "testName<-",
    "testStatistic",
    "testStatPar",
    "updateGenes",
    "updateGroup",
    "updateTerm<-",
    "usedGO",
    "Weights",
    "Weights<-",
    "whichAlgorithms",
    "whichTests"
  ],
  "_datasets": [
    {
      "name": "affyLib",
      "title": "A toy example of a list of gene identifiers and the respective p-values",
      "object": "geneList",
      "file": "geneList.rda",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "geneList",
      "title": "A toy example of a list of gene identifiers and the respective p-values",
      "object": "geneList",
      "file": "geneList.rda",
      "class": [
        "numeric"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "GOdata",
      "title": "Sample topGOdata and topGOresult objects",
      "object": "GOdata",
      "file": "GOdata.rda",
      "class": [
        "topGOdata"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    },
    {
      "name": "resultFisher",
      "title": "Sample topGOdata and topGOresult objects",
      "object": "results.tGO",
      "file": "results.tGO.rda",
      "class": [
        "topGOresult"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    },
    {
      "name": "resultKS",
      "title": "Sample topGOdata and topGOresult objects",
      "object": "results.tGO",
      "file": "results.tGO.rda",
      "class": [
        "topGOresult"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    },
    {
      "name": "topDiffGenes",
      "title": "A toy example of a list of gene identifiers and the respective p-values",
      "object": "geneList",
      "file": "geneList.rda",
      "class": [
        "function"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "topGO-package",
      "title": "Enrichment analysis for Gene Ontology",
      "topics": [
        "topGO-package",
        "topGO"
      ]
    },
    {
      "page": "annFUN",
      "title": "Functions which map gene identifiers to GO terms",
      "topics": [
        "annFUN",
        "annFUN.db",
        "annFUN.file",
        "annFUN.gene2GO",
        "annFUN.GO2genes",
        "annFUN.org",
        "inverseList",
        "readMappings"
      ]
    },
    {
      "page": "classicCount-class",
      "title": "Class \"classicCount\"",
      "topics": [
        "classicCount-class",
        "contTable",
        "contTable,classicCount-method",
        "GOFisherTest,classicCount-method",
        "initialize,classicCount-method",
        "numSigAll",
        "numSigAll,classicCount-method",
        "numSigMembers",
        "numSigMembers,classicCount-method",
        "sigAllMembers",
        "sigAllMembers,classicCount-method",
        "sigMembers",
        "sigMembers,classicCount-method",
        "sigMembers<-",
        "sigMembers<-,classicCount-method"
      ]
    },
    {
      "page": "classicExpr-class",
      "title": "Class \"classicExpr\"",
      "topics": [
        "allMembers<-,classicExpr-method",
        "classicExpr-class",
        "emptyExpr,classicExpr-method",
        "GOglobalTest,classicExpr-method",
        "initialize,classicExpr-method",
        "membersExpr",
        "membersExpr,classicExpr-method",
        "pType",
        "pType,classicExpr-method",
        "pType<-",
        "pType<-,classicExpr-method"
      ]
    },
    {
      "page": "classicScore-class",
      "title": "Class \"classicScore\"",
      "topics": [
        "allScore",
        "allScore,classicScore,logical-method",
        "allScore,classicScore,missing-method",
        "classicScore-class",
        "GOKSTest,classicScore-method",
        "GOKSTiesTest,classicScore-method",
        "GOSumTest,classicScore-method",
        "GOtTest,classicScore-method",
        "initialize,classicScore-method",
        "membersScore",
        "membersScore,classicScore-method",
        "rankMembers",
        "rankMembers,classicScore-method",
        "score<-",
        "score<-,classicScore-method",
        "scoreOrder",
        "scoreOrder,classicScore-method"
      ]
    },
    {
      "page": "dagFunctions",
      "title": "Utility functions to work with Directed Acyclic Graphs (DAG)",
      "topics": [
        "buildLevels",
        "getGraphRoot",
        "getNoOfLevels",
        "reverseArch"
      ]
    },
    {
      "page": "diagnosticMethods",
      "title": "Diagnostic functions for topGOdata and topGOresult objects.",
      "topics": [
        "GenTable",
        "GenTable,topGOdata-method",
        "printGenes",
        "printGenes,topGOdata,character,character-method",
        "printGenes,topGOdata,character,missing-method",
        "printGenes-methods",
        "showGroupDensity"
      ]
    },
    {
      "page": "elimCount-class",
      "title": "Classes \"elimCount\" and \"weight01Count\"",
      "topics": [
        "contTable,elimCount-method",
        "cutOff",
        "cutOff,elimCount-method",
        "cutOff<-",
        "cutOff<-,elimCount-method",
        "depth",
        "depth,leaCount-method",
        "depth<-",
        "depth<-,leaCount-method",
        "elim",
        "elim,elimCount-method",
        "elim,weight01Count-method",
        "elim<-",
        "elim<-,elimCount-method",
        "elim<-,weight01Count-method",
        "elimCount-class",
        "GOFisherTest,elimCount-method",
        "initialize,elimCount-method",
        "initialize,leaCount-method",
        "initialize,weight01Count-method",
        "leaCount-class",
        "numAllMembers,elimCount-method",
        "numAllMembers,weight01Count-method",
        "numMembers,elimCount-method",
        "numMembers,weight01Count-method",
        "numSigAll,elimCount-method",
        "numSigAll,weight01Count-method",
        "numSigMembers,elimCount-method",
        "numSigMembers,weight01Count-method",
        "sigAllMembers,elimCount-method",
        "sigAllMembers,weight01Count-method",
        "sigMembers,elimCount-method",
        "sigMembers,weight01Count-method",
        "sigMembers<-,elimCount-method",
        "weight01Count-class"
      ]
    },
    {
      "page": "elimExpr-class",
      "title": "Class \"elimExpr\"",
      "topics": [
        "allMembers,weight01Expr-method",
        "cutOff,elimExpr-method",
        "cutOff<-,elimExpr-method",
        "depth,leaExpr-method",
        "depth<-,leaExpr-method",
        "elim,weight01Expr-method",
        "elim<-,weight01Expr-method",
        "elimExpr-class",
        "initialize,elimExpr-method",
        "initialize,leaExpr-method",
        "initialize,weight01Expr-method",
        "leaExpr-class",
        "members,weight01Expr,missing-method",
        "numAllMembers,weight01Expr-method",
        "numMembers,weight01Expr-method",
        "weight01Expr-class"
      ]
    },
    {
      "page": "elimScore-class",
      "title": "Classes \"elimScore\" and \"weight01Score\"",
      "topics": [
        "allMembers,elimScore-method",
        "allMembers,weight01Score-method",
        "allScore,elimScore,logical-method",
        "allScore,elimScore,missing-method",
        "allScore,weight01Score,logical-method",
        "allScore,weight01Score,missing-method",
        "alternative,elimScore-method",
        "cutOff,elimScore-method",
        "cutOff<-,elimScore-method",
        "depth,leaScore-method",
        "depth<-,leaScore-method",
        "elim,elimScore-method",
        "elim,weight01Score-method",
        "elim<-,elimScore-method",
        "elim<-,weight01Score-method",
        "elimScore-class",
        "initialize,elimScore-method",
        "initialize,leaScore-method",
        "initialize,weight01Score-method",
        "leaScore-class",
        "members,elimScore-method",
        "members,weight01Score,missing-method",
        "membersScore,elimScore-method",
        "membersScore,weight01Score-method",
        "numAllMembers,elimScore-method",
        "numAllMembers,weight01Score-method",
        "numMembers,elimScore-method",
        "numMembers,weight01Score-method",
        "rankMembers,elimScore-method",
        "rankMembers,weight01Score-method",
        "score<-,elimScore-method",
        "weight01Score-class"
      ]
    },
    {
      "page": "GOTests",
      "title": "Gene set tests statistics",
      "topics": [
        "GOFisherTest",
        "GOglobalTest",
        "GOKSTest",
        "GOKSTiesTest",
        "GOSumTest",
        "GOtTest",
        "permSumStats",
        "permSumStats.all"
      ]
    },
    {
      "page": "geneList",
      "title": "A toy example of a list of gene identifiers and the respective p-values",
      "topics": [
        "affyLib",
        "geneList",
        "topDiffGenes"
      ]
    },
    {
      "page": "getPvalues",
      "title": "Convenient function to compute p-values from a gene expression matrix.",
      "topics": [
        "getPvalues"
      ]
    },
    {
      "page": "getSigGroups",
      "title": "Interfaces for running the enrichment tests",
      "topics": [
        "getSigGroups",
        "getSigGroups,topGOdata,classicCount-method",
        "getSigGroups,topGOdata,classicExpr-method",
        "getSigGroups,topGOdata,classicScore-method",
        "getSigGroups,topGOdata,elimCount-method",
        "getSigGroups,topGOdata,elimExpr-method",
        "getSigGroups,topGOdata,elimScore-method",
        "getSigGroups,topGOdata,leaCount-method",
        "getSigGroups,topGOdata,leaExpr-method",
        "getSigGroups,topGOdata,leaScore-method",
        "getSigGroups,topGOdata,parentChild-method",
        "getSigGroups,topGOdata,pC-method",
        "getSigGroups,topGOdata,weight01Count-method",
        "getSigGroups,topGOdata,weight01Expr-method",
        "getSigGroups,topGOdata,weight01Score-method",
        "getSigGroups,topGOdata,weightCount-method",
        "getSigGroups-methods",
        "runTest",
        "runTest,topGOdata,character,character-method",
        "runTest,topGOdata,missing,character-method",
        "whichAlgorithms",
        "whichTests"
      ]
    },
    {
      "page": "GOdata",
      "title": "Sample topGOdata and topGOresult objects",
      "topics": [
        "GOdata",
        "resultFisher",
        "resultKS"
      ]
    },
    {
      "page": "groupGOTerms",
      "title": "Grouping of GO terms into the three ontologies",
      "topics": [
        "GOBPTerm",
        "GOCCTerm",
        "GOMFTerm",
        "groupGOTerms"
      ]
    },
    {
      "page": "groupStats-class",
      "title": "Class \"groupStats\"",
      "topics": [
        "allMembers",
        "allMembers,groupStats-method",
        "allMembers<-",
        "allMembers<-,groupStats-method",
        "groupStats-class",
        "initialize,groupStats-method",
        "members",
        "members,groupStats,missing-method",
        "members<-",
        "members<-,groupStats-method",
        "Name",
        "Name,groupStats-method",
        "Name<-",
        "Name<-,groupStats-method",
        "numAllMembers",
        "numAllMembers,groupStats-method",
        "numMembers",
        "numMembers,groupStats-method",
        "runTest,groupStats,missing,missing-method",
        "runTest,groupStats-method",
        "testStatistic",
        "testStatistic,groupStats-method",
        "testStatPar",
        "testStatPar,groupStats-method",
        "updateGroup",
        "updateGroup,groupStats,character,character-method"
      ]
    },
    {
      "page": "inducedGraph",
      "title": "The subgraph induced by a set of nodes.",
      "topics": [
        "inducedGraph",
        "nodesInInducedGraph"
      ]
    },
    {
      "page": "parentChild-class",
      "title": "Classes \"parentChild\" and \"pC\"",
      "topics": [
        "allMembers,parentChild-method",
        "allMembers<-,parentChild-method",
        "allMembers<-,pC-method",
        "allParents",
        "allParents,parentChild-method",
        "initialize,parentChild-method",
        "initialize,pC-method",
        "joinFun",
        "joinFun,parentChild-method",
        "numAllMembers,parentChild-method",
        "numSigAll,parentChild-method",
        "parentChild-class",
        "pC-class",
        "sigAllMembers,parentChild-method",
        "sigMembers<-,parentChild-method",
        "sigMembers<-,pC-method",
        "updateGroup,parentChild,missing,character-method",
        "updateGroup,pC,missing,character-method",
        "updateGroup,pC,missing,missing-method"
      ]
    },
    {
      "page": "printGraph-methods",
      "title": "Visualisation functions",
      "topics": [
        "GOplot",
        "printGraph",
        "printGraph,topGOdata,topGOresult,numeric,missing-method",
        "printGraph,topGOdata,topGOresult,numeric,topGOresult-method",
        "printGraph-methods",
        "showSigOfNodes"
      ]
    },
    {
      "page": "topGOdata-class",
      "title": "Class \"topGOdata\"",
      "topics": [
        "allGenes",
        "allGenes,topGOdata-method",
        "attrInTerm",
        "attrInTerm,topGOdata,character,character-method",
        "attrInTerm,topGOdata,character,missing-method",
        "countGenesInTerm",
        "countGenesInTerm,topGOdata,character-method",
        "countGenesInTerm,topGOdata,missing-method",
        "description",
        "description,topGOdata-method",
        "description<-",
        "description<-,topGOdata,ANY-method",
        "expressionMatrix",
        "expressionMatrix,topGOdata-method",
        "feasible",
        "feasible,topGOdata-method",
        "feasible<-",
        "feasible<-,topGOdata-method",
        "genes",
        "genes,topGOdata-method",
        "geneScore",
        "geneScore,topGOdata,character-method",
        "geneScore,topGOdata,missing-method",
        "geneScore,topGOdata-method",
        "geneSelectionFun",
        "geneSelectionFun,topGOdata-method",
        "geneSelectionFun<-",
        "geneSelectionFun<-,topGOdata-method",
        "genesInTerm",
        "genesInTerm,topGOdata,character-method",
        "genesInTerm,topGOdata,missing-method",
        "graph",
        "graph,topGOdata-method",
        "graph<-",
        "graph<-,topGOdata-method",
        "initialize,topGOdata-method",
        "numGenes",
        "numGenes,topGOdata-method",
        "numSigGenes",
        "numSigGenes,topGOdata-method",
        "ontology",
        "ontology,topGOdata-method",
        "ontology<-",
        "ontology<-,topGOdata-method",
        "phenotype",
        "phenotype,topGOdata-method",
        "print,topGOdata-method",
        "scoresInTerm",
        "scoresInTerm,topGOdata,character-method",
        "scoresInTerm,topGOdata,missing-method",
        "show,topGOdata-method",
        "sigGenes",
        "sigGenes,topGOdata-method",
        "termStat",
        "termStat,topGOdata,character-method",
        "termStat,topGOdata,missing-method",
        "topGOdata-class",
        "updateGenes",
        "updateGenes,topGOdata,factor,missing-method",
        "updateGenes,topGOdata,numeric,function-method",
        "updateTerm<-",
        "updateTerm<-,topGOdata,character-method",
        "usedGO",
        "usedGO,topGOdata-method"
      ]
    },
    {
      "page": "topGOresult-class",
      "title": "Class \"topGOresult\"",
      "topics": [
        "algorithm",
        "algorithm,topGOresult-method",
        "algorithm<-",
        "algorithm<-,topGOresult-method",
        "combineResults",
        "description,topGOresult-method",
        "description<-,topGOresult,ANY-method",
        "geneData",
        "geneData,topGOresult-method",
        "geneData<-",
        "geneData<-,topGOresult-method",
        "initialize,topGOresult-method",
        "print,topGOresult-method",
        "score",
        "score,topGOresult-method",
        "score<-,topGOresult-method",
        "show,topGOresult-method",
        "testName",
        "testName,topGOresult-method",
        "testName<-",
        "testName<-,topGOresult-method",
        "topGOresult-class"
      ]
    },
    {
      "page": "weightCount-class",
      "title": "Class \"weightCount\"",
      "topics": [
        "allMembers,weightCount-method",
        "getSigRatio",
        "getSigRatio,weightCount-method",
        "initialize,weightCount-method",
        "members,weightCount-method",
        "Name,weightCount-method",
        "numAllMembers,weightCount-method",
        "numMembers,weightCount-method",
        "numSigAll,weightCount-method",
        "numSigMembers,weightCount-method",
        "penalise",
        "penalise,weightCount,numeric,numeric-method",
        "roundFun",
        "roundFun,weightCount-method",
        "significant",
        "significant,weightCount-method",
        "sigRatio",
        "sigRatio,weightCount-method",
        "sigRatio<-",
        "sigRatio<-,weightCount-method",
        "testStatistic,weightCount-method",
        "testStatPar,weightCount-method",
        "updateGroup,weightCount,character,character-method",
        "weightCount-class",
        "Weights",
        "Weights,weightCount,logical-method",
        "Weights,weightCount,missing-method",
        "Weights,weightCount-method",
        "Weights<-",
        "Weights<-,weightCount-method"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/topGO/raw/HEAD/README.md",
  "_rundeps": [
    "AnnotationDbi",
    "askpass",
    "Biobase",
    "BiocBaseUtils",
    "BiocGenerics",
    "Biostrings",
    "bit",
    "bit64",
    "blob",
    "cachem",
    "cli",
    "cpp11",
    "crayon",
    "curl",
    "DBI",
    "fastmap",
    "generics",
    "glue",
    "GO.db",
    "graph",
    "httr",
    "IRanges",
    "jsonlite",
    "KEGGREST",
    "lattice",
    "lifecycle",
    "matrixStats",
    "memoise",
    "mime",
    "openssl",
    "pkgconfig",
    "png",
    "R6",
    "rlang",
    "RSQLite",
    "S4Vectors",
    "Seqinfo",
    "SparseM",
    "sys",
    "vctrs",
    "XVector"
  ],
  "_vignettes": [
    {
      "source": "topGO_manual.Rmd",
      "filename": "topGO_manual.html",
      "title": "Gene set enrichment analysis with topGO",
      "author": "Adrian Alexa, Jörg Rahnenführer, Federico Marini",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Installation",
        "Quick start guide",
        "Data preparation",
        "Performing the enrichment tests",
        "Analysis of results",
        "The gene universe and the set of  interesting genes",
        "The topGOdata object",
        "Custom annotations",
        "Predefined list of interesting genes",
        "Using the genes score",
        "Filtering and missing GO annotations",
        "Working with the topGOdata object",
        "Running the enrichment tests",
        "Defining and running the test",
        "The groupStats classes",
        "Performing the test",
        "The adjustment of $p$-values",
        "runTest: a high-level interface for testing",
        "Interpretation and visualization of results",
        "The topGOresult object",
        "Summarising the results",
        "Analysing individual GOs",
        "Visualising the GO structure",
        "Session Information",
        "References"
      ],
      "created": "2025-07-18 12:19:37",
      "modified": "2025-07-18 12:19:37",
      "commits": 1
    }
  ],
  "_score": 11.127412921441458,
  "_indexed": true,
  "_nocasepkg": "topgo",
  "_universes": [
    "bioc",
    "federicomarini"
  ],
  "_binaries": [
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