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It provides efficient\nimplementations for 1.the popular synergy scoring models,\nincluding HSA, Loewe, Bliss, and ZIP to quantify the degree of\ndrug combination synergy; 2. higher order drug combination data\nanalysis and synergy landscape visualization for unlimited\nnumber of drugs in a combination; 3. statistical analysis of\ndrug combination synergy and sensitivity with confidence\nintervals and p-values; 4. synergy barometer for harmonizing\nmultiple synergy scoring methods to provide a consensus metric\nof synergy; 5. evaluation of synergy and sensitivity\nsimultaneously to provide an unbiased interpretation of the\nclinical potential of the drug combinations. Based on this\npackage, we also provide a web application\n(http://www.synergyfinder.org) for users who prefer graphical\nuser interface.", "License": "Mozilla Public License 2.0", "Encoding": "UTF-8", "URL": "http://www.synergyfinder.org", "RoxygenNote": "7.2.3", "VignetteBuilder": "knitr", "biocViews": "Software, StatisticalMethod", "Config/pak/sysreqs": "libabsl-dev cmake libfontconfig1-dev\nlibfreetype6-dev libfribidi-dev libgdal-dev gdal-bin\nlibgeos-dev make libharfbuzz-dev libicu-dev libjpeg-dev\nlibpng-dev libtiff-dev libuv1-dev libwebp-dev libxml2-dev\nlibssl-dev libproj-dev libsqlite3-dev libudunits2-dev\nlibx11-dev zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:44:14 UTC", "RemoteUrl": "https://github.com/bioc/synergyfinder", "RemoteRef": "HEAD", "RemoteSha": "ebf173dc528391196df1af73b3483a3851b4c7b0", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-30 09:47:52 UTC", "User": "root" }, "Author": "Shuyu Zheng [aut, 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combination screening", "7.1 Reshaping and pre-processing", "7.2 Drug synergy scoring", "7.3 Sensitivity scoring", "7.4 Visualization", "Citation", "For use of SynergyFinder R package or web application:", "For use of ZIP synergy scoring:", "For how to harmonize the different synergy scoring methods:", "For general ideas of drug combination therapies:", "For retrieving the most comprehensive drug combination data resources and their sensitivity and synergy results by SynergyFinder, please go to DrugComb :", "For use of combination sensitivity score:", "Reference" ], "created": "2021-05-23 11:16:40", "modified": "2022-11-01 09:10:49", "commits": 10 } ], "_score": 5.5490032620257885, "_indexed": true, "_nocasepkg": "synergyfinder", "_universes": [ "bioc", "shuyuzheng" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "3.21.0", "date": "2026-05-30T10:25:53.000Z", "distro": "noble", "commit": "ebf173dc528391196df1af73b3483a3851b4c7b0", "fileid": 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