{ "_id": "6a1af04f1d7bb097a09f68e0", "Package": "synapsis", "Type": "Package", "Title": "An R package to automate the analysis of double-strand break\nrepair during meiosis", "Version": "1.19.0", "Authors@R": "c(person(given = \"Lucy\",\nfamily = \"McNeill\",\nrole = c(\"aut\", \"cre\", \"cph\"),\nemail = \"luc.mcneill@gmail.com\",\ncomment = c(ORCID = \"0000-0003-1752-4882\")),\nperson(given = \"Wayne\",\nfamily = \"Crismani\",\nrole = c(\"rev\", \"ctb\"),\ncomment = c(ORCID = \"0000-0003-0143-8293\")))", "Description": "Synapsis is a Bioconductor software package for automated\n(unbiased and reproducible) analysis of meiotic\nimmunofluorescence datasets. The primary functions of the\nsoftware can i) identify cells in meiotic prophase that are\nlabelled by a synaptonemal complex axis or central element\nprotein, ii) isolate individual synaptonemal complexes and\nmeasure their physical length, iii) quantify foci and\nco-localise them with synaptonemal complexes, iv) measure\ninterference between synaptonemal complex-associated foci. The\nsoftware has applications that extend to multiple species and\nto the analysis of other proteins that label meiotic prophase\nchromosomes. The software converts meiotic immunofluorescence\nimages into R data frames that are compatible with machine\nlearning methods. Given a set of microscopy images of meiotic\nspread slides, synapsis crops images around individual single\ncells, counts colocalising foci on strands on a per cell basis,\nand measures the distance between foci on any given strand.", "biocViews": "Software, SingleCell", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "RoxygenNote": "7.1.1", "VignetteBuilder": "knitr", "Config/testthat/edition": "3", "Config/pak/sysreqs": "cmake libfftw3-dev make libjpeg-dev libpng-dev\nlibtiff-dev libuv1-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:57:20 UTC", "RemoteUrl": "https://github.com/bioc/synapsis", "RemoteRef": "HEAD", "RemoteSha": "9930dc1dc939af0c1399393d5aa62839f00da424", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-30 09:43:32 UTC", "User": "root" }, "Author": "Lucy McNeill [aut, cre, cph] (ORCID:\n),\nWayne Crismani [rev, ctb] (ORCID:\n)", "Maintainer": "Lucy McNeill ", "MD5sum": "33c55024baa70bee73d450a1d58698f4", "_user": 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