{
  "_id": "6a494d27f6c47c4419499a93",
  "Package": "spillR",
  "Type": "Package",
  "Title": "Spillover Compensation in Mass Cytometry Data",
  "Version": "1.9.0",
  "Authors@R": "c(\nperson(\"Marco\", \"Guazzini\",\nemail= \"m.guazzini@student.maastrichtuniversity.nl\",\nrole = c(\"aut\", \"cre\"), comment = c(ORCID = \"0009-0007-8111-5772\")),\nperson(\"Alexander G.\", \"Reisach\" ,\nemail = \"alexander.reisach@u-paris.fr\",\nrole = \"aut\", comment = c(ORCID = \"0009-0003-5057-6278\")),\nperson(\"Sebastian\", \"Weichwald\",\nemail = \"sweichwald@math.ku.dk\",\nrole = \"aut\", comment = c(ORCID = \"0000-0003-0169-7244\")),\nperson(\"Christof\", \"Seiler\",\nemail = \"christof.seiler@maastrichtuniversity.nl\",\nrole = \"aut\", comment = c(ORCID = \"0000-0001-8802-3642\")))",
  "Description": "Channel interference in mass cytometry can cause spillover\nand may result in miscounting of protein markers. We develop a\nnonparametric finite mixture model and use the mixture\ncomponents to estimate the probability of spillover. We\nimplement our method using expectation-maximization to fit the\nmixture model.",
  "biocViews": "FlowCytometry, ImmunoOncology, MassSpectrometry,\nPreprocessing, SingleCell, Software, StatisticalMethod,\nVisualization, Regression",
  "License": "LGPL-3",
  "Encoding": "UTF-8",
  "Config/testthat/edition": "3",
  "RoxygenNote": "7.3.1",
  "VignetteBuilder": "knitr",
  "Config/pak/sysreqs": "cmake libfontconfig1-dev libfreetype6-dev\nlibglpk-dev make libicu-dev libpng-dev libxml2-dev libssl-dev\nperl zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 13:02:05 UTC",
  "RemoteUrl": "https://github.com/bioc/spillR",
  "RemoteRef": "HEAD",
  "RemoteSha": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-07-03 21:08:52 UTC",
    "User": "root"
  },
  "Author": "Marco Guazzini [aut, cre] (ORCID:\n<https://orcid.org/0009-0007-8111-5772>),\nAlexander G. Reisach [aut] (ORCID:\n<https://orcid.org/0009-0003-5057-6278>),\nSebastian Weichwald [aut] (ORCID:\n<https://orcid.org/0000-0003-0169-7244>),\nChristof Seiler [aut] (ORCID: <https://orcid.org/0000-0001-8802-3642>)",
  "Maintainer": "Marco Guazzini <m.guazzini@student.maastrichtuniversity.nl>",
  "_user": "bioc",
  "_type": "src",
  "_file": "spillR_1.9.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/05de610504860e88396eed7c8a74b0d0b6ee15857cf4551163ce528ff5ebd94c",
  "_filesize": 317843,
  "_sha256": "05de610504860e88396eed7c8a74b0d0b6ee15857cf4551163ce528ff5ebd94c",
  "_expires": "2026-10-12T18:12:53.000Z",
  "_created": "2026-07-03T21:08:52.000Z",
  "_published": "2026-07-04T18:12:55.345Z",
  "_bioccheck": {
    "error": 0,
    "warning": 0,
    "note": 5
  },
  "_host": "GitHub-Actions",
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444",
  "_status": "success",
  "_upstream": "https://github.com/bioc/spillR",
  "_commit": {
    "id": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777381325
  },
  "_maintainer": {
    "name": "Marco Guazzini",
    "email": "m.guazzini@student.maastrichtuniversity.nl",
    "login": "marcoguazzini",
    "description": "",
    "uuid": 79971842
  },
  "_distro": "resolute",
  "_jobs": [
    {
      "job": 85155260651,
      "time": 248,
      "config": "bioc-checks",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "8074841478"
    },
    {
      "job": 85155260521,
      "time": 544,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "8074893734"
    },
    {
      "job": 85155260630,
      "time": 528,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "8074890958"
    },
    {
      "job": 85155260370,
      "time": 261,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "8074843962"
    },
    {
      "job": 85155260365,
      "time": 280,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "8074847245"
    },
    {
      "job": 85155260132,
      "time": 319,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "8074796737"
    },
    {
      "job": 85155260525,
      "time": 221,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "8074836908"
    },
    {
      "job": 85155260482,
      "time": 404,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "8074869000"
    },
    {
      "job": 85155260667,
      "time": 402,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "8074868585"
    },
    {
      "job": 85155260486,
      "time": 365,
      "config": "windows-release",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "8074862006"
    }
  ],
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.3.0",
      "role": "Depends"
    },
    {
      "package": "SummarizedExperiment",
      "role": "Depends"
    },
    {
      "package": "CATALYST",
      "role": "Depends"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "tibble",
      "role": "Imports"
    },
    {
      "package": "tidyselect",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "tidyr",
      "role": "Imports"
    },
    {
      "package": "spatstat.univar",
      "role": "Imports"
    },
    {
      "package": "S4Vectors",
      "role": "Imports"
    },
    {
      "package": "parallel",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "cowplot",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "BiocStyle",
      "role": "Suggests"
    },
    {
      "package": "hexbin",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-44",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.9.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.8.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "flowcytometry",
    "immunooncology",
    "massspectrometry",
    "preprocessing",
    "singlecell",
    "software",
    "statisticalmethod",
    "visualization",
    "regression"
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "followers": 445,
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_searchresults": 3,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "extra/spillR.html",
    "manual.pdf"
  ],
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "compCytof",
    "generate_bead",
    "generate_real",
    "plotDiagnostics"
  ],
  "_help": [
    {
      "page": "compCytof",
      "title": "Compute spillover probability and correct for spillover",
      "topics": [
        "compCytof"
      ]
    },
    {
      "page": "compensate",
      "title": "Compute spillover probability and correct for spillover",
      "topics": [
        "compensate"
      ]
    },
    {
      "page": "compensate_naive",
      "title": "Compute spillover probability and correct for spillover from beads only",
      "topics": [
        "compensate_naive"
      ]
    },
    {
      "page": "generate_bead",
      "title": "Generate dataset for vignettes and simulation studies",
      "topics": [
        "generate_bead"
      ]
    },
    {
      "page": "generate_real",
      "title": "Generate dataset for vignettes and simulation studies",
      "topics": [
        "generate_real"
      ]
    },
    {
      "page": "plotDiagnostics",
      "title": "Compute spillover probability and correct for spillover",
      "topics": [
        "plotDiagnostics"
      ]
    },
    {
      "page": "tfm",
      "title": "Variance stabilizing transform of counts",
      "topics": [
        "tfm"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/spillR/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "ALL",
    "assorthead",
    "backports",
    "base64enc",
    "beachmat",
    "beeswarm",
    "BH",
    "Biobase",
    "BiocGenerics",
    "biocmake",
    "BiocNeighbors",
    "BiocParallel",
    "BiocSingular",
    "boot",
    "broom",
    "car",
    "carData",
    "CATALYST",
    "circlize",
    "cli",
    "clue",
    "cluster",
    "codetools",
    "colorRamps",
    "colorspace",
    "ComplexHeatmap",
    "ConsensusClusterPlus",
    "corrplot",
    "cowplot",
    "cpp11",
    "crayon",
    "cytolib",
    "DelayedArray",
    "Deriv",
    "digest",
    "dir.expiry",
    "doBy",
    "doParallel",
    "dplyr",
    "dqrng",
    "drc",
    "farver",
    "filelock",
    "flowCore",
    "FlowSOM",
    "FNN",
    "foreach",
    "forecast",
    "formatR",
    "Formula",
    "fracdiff",
    "futile.logger",
    "futile.options",
    "generics",
    "GenomicRanges",
    "GetoptLong",
    "ggbeeswarm",
    "ggforce",
    "ggnewscale",
    "ggplot2",
    "ggpubr",
    "ggrepel",
    "ggridges",
    "ggsci",
    "ggsignif",
    "GlobalOptions",
    "glue",
    "gridExtra",
    "gtable",
    "gtools",
    "igraph",
    "IRanges",
    "irlba",
    "isoband",
    "iterators",
    "jsonlite",
    "labeling",
    "lambda.r",
    "lattice",
    "lifecycle",
    "lme4",
    "lmtest",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixGenerics",
    "MatrixModels",
    "matrixStats",
    "mgcv",
    "minqa",
    "modelr",
    "multcomp",
    "mvtnorm",
    "nlme",
    "nloptr",
    "nnet",
    "nnls",
    "numDeriv",
    "pbkrtest",
    "pheatmap",
    "pillar",
    "pkgconfig",
    "plotrix",
    "plyr",
    "png",
    "polyclip",
    "polynom",
    "purrr",
    "quantreg",
    "R6",
    "rbibutils",
    "RColorBrewer",
    "Rcpp",
    "RcppAnnoy",
    "RcppArmadillo",
    "RcppEigen",
    "RcppML",
    "RcppProgress",
    "Rdpack",
    "reformulas",
    "reshape2",
    "Rhdf5lib",
    "rjson",
    "rlang",
    "RProtoBufLib",
    "RSpectra",
    "rstatix",
    "rsvd",
    "Rtsne",
    "S4Arrays",
    "S4Vectors",
    "S7",
    "sandwich",
    "ScaledMatrix",
    "scales",
    "scater",
    "scuttle",
    "Seqinfo",
    "shape",
    "SingleCellExperiment",
    "sitmo",
    "snow",
    "SparseArray",
    "SparseM",
    "spatstat.univar",
    "spatstat.utils",
    "stringi",
    "stringr",
    "SummarizedExperiment",
    "survival",
    "systemfonts",
    "TH.data",
    "tibble",
    "tidyr",
    "tidyselect",
    "timeDate",
    "tweenr",
    "urca",
    "utf8",
    "uwot",
    "vctrs",
    "vipor",
    "viridis",
    "viridisLite",
    "withr",
    "XML",
    "XVector",
    "zoo"
  ],
  "_vignettes": [
    {
      "source": "spillR-vignette.Rmd",
      "filename": "spillR-vignette.html",
      "title": "spillR Vignette",
      "author": "Marco Guazzini, Alexander G. Reisach, Sebastian Weichwald, Christof Seiler",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Installation",
        "Data",
        "Compensation Workflow",
        "Diagnostic Plot",
        "Session Info",
        "References"
      ],
      "created": "2023-06-15 13:28:22",
      "modified": "2024-03-18 15:51:23",
      "commits": 26
    }
  ],
  "_score": 4,
  "_indexed": true,
  "_nocasepkg": "spillr",
  "_universes": [
    "bioc",
    "marcoguazzini"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.9.0",
      "date": "2026-07-03T21:13:35.000Z",
      "distro": "resolute",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/3f0055d6e4b3cb45a68ca294e5cf5d026cc1683f82b46072b884d5903882593f",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "1.9.0",
      "date": "2026-07-03T21:13:30.000Z",
      "distro": "resolute",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/bb730a2ea0f623b9e29f70af5af67a029d3063df28e32eccdfff197263ce4751",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.9.0",
      "date": "2026-07-03T21:10:49.000Z",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/4a3c11f92053dfed0d67f49c39574e0af058fa44199e7d7d499764fa64549ebd",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "1.9.0",
      "date": "2026-07-03T21:10:56.000Z",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/89b878853bfe42a79020814379ec92f51c513c17b9aa3078fbd52c39af307cfd",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.9.0",
      "date": "2026-07-03T21:13:02.000Z",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/6df6abfeeed08f59ac7e7f7b935867422aa2d565fa4a3731372f2675ba9261c2",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.9.0",
      "date": "2026-07-03T21:10:52.000Z",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/9465df98e0e0758cf8884a34103ea4a2b9fa75fe77983801620d5f59fd7cc8d5",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.9.0",
      "date": "2026-07-03T21:11:06.000Z",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/00a65e6a14d64084d0a1fc4ad25bd52627351f4e5f98acabfa7a148d2118790c",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "1.9.0",
      "date": "2026-07-03T21:10:49.000Z",
      "commit": "8db8248296144dbe26d8dfd56d1b1c64298a5723",
      "fileid": "https://r2.ropensci.org/c80fa2ec48013141ed986fbe27662c4aba78ffee3d5e796907eaa173f6afb701",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/28683301444"
    }
  ]
}