{ "_id": "6a1ae40c1d7bb097a09ef6b4", "Package": "scMET", "Type": "Package", "Title": "Bayesian modelling of cell-to-cell DNA methylation heterogeneity", "Version": "1.15.0", "Authors@R": "c(person(given = \"Andreas C.\",\nfamily = \"Kapourani\",\nrole = c(\"aut\", \"cre\"),\nemail = \"kapouranis.andreas@gmail.com\",\ncomment = c(ORCID = \"0000-0003-2303-1953\")),\nperson(given = \"John\",\nfamily = \"Riddell\",\nrole = c(\"ctb\")))", "Description": "High-throughput single-cell measurements of DNA methylomes\ncan quantify methylation heterogeneity and uncover its role in\ngene regulation. However, technical limitations and sparse\ncoverage can preclude this task. scMET is a hierarchical\nBayesian model which overcomes sparsity, sharing information\nacross cells and genomic features to robustly quantify genuine\nbiological heterogeneity. scMET can identify highly variable\nfeatures that drive epigenetic heterogeneity, and perform\ndifferential methylation and variability analyses. We\nillustrate how scMET facilitates the characterization of\nepigenetically distinct cell populations and how it enables the\nformulation of novel hypotheses on the epigenetic regulation of\ngene expression.", "License": "GPL-3", "Encoding": "UTF-8", "LazyData": "true", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.2.0", "Biarch": "true", "BugReports": "https://github.com/andreaskapou/scMET/issues", "SystemRequirements": "GNU make", "biocViews": "ImmunoOncology, DNAMethylation, DifferentialMethylation,\nDifferentialExpression, GeneExpression, GeneRegulation,\nEpigenetics, Genetics, Clustering, FeatureExtraction,\nRegression, Bayesian, Sequencing, Coverage, SingleCell", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "cmake make libuv1-dev zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:58:45 UTC", "RemoteUrl": "https://github.com/bioc/scMET", "RemoteRef": "HEAD", "RemoteSha": "be256cc3117c8bb503b95869af557f44df404f00", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-05-30 09:33:27 UTC", "User": "root" }, "Author": "Andreas C. 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