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Standard pseudo-bulk DE tools confound these two\nsources of signal, producing spurious DE calls when subtype\nproportions differ between conditions. scCompoundDE fits\nper-subtype limma-voom models, estimates subtype proportion\nshifts, and uses a z-score-normalized decomposition to assign\neach gene a TC_ratio score — the fraction of its DE signal\nattributable to transcription versus composition. Genes are\nthen classified as transcriptional (real biology),\ncompositional (artifact), or mixed (requires caution). 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