{
  "_id": "6a1afe081d7bb097a09fe3af",
  "Package": "recountmethylation",
  "Version": "1.23.0",
  "Title": "Access and analyze public DNA methylation array data\ncompilations",
  "Authors@R": "c(person(c(\"Sean\", \"K\"), \"Maden\", role = c(\"cre\", \"aut\"),\nemail = \"maden@ohsu.edu\", comment = c(ORCID = \"0000-0002-2212-4894\")),\nperson(\"Brian\", \"Walsh\", role = \"aut\", email = \"walsbr@ohsu.edu\", comment = c(ORCID = \"0000-0003-0913-1528\")),\nperson(\"Kyle\", \"Ellrott\", role = \"aut\", email = \"kellrott@gmail.com\", comment = c(ORCID = \"0000-0002-6573-5900\")),\nperson(\"Kasper D\", \"Hansen\", role = \"aut\", email = \"hansen@jhsph.edu\", comment = c(ORCID = \"0000-0003-0086-0687\")),\nperson(\"Reid F\", \"Thompson\", role = \"aut\", comment = c(ORCID = \"0000-0003-3661-5296\")),\nperson(\"Abhinav\", \"Nellore\", role = \"aut\", email = \"nellore@ohsu.edu\", comment = c(ORCID = \"0000-0001-8145-1484\")))",
  "Description": "Resources for cross-study analyses of public DNAm array\ndata from NCBI GEO repo, produced using Illumina's Infinium\nHumanMethylation450K (HM450K) and MethylationEPIC (EPIC)\nplatforms. Provided functions enable download, summary, and\nfiltering of large compilation files. Vignettes detail\nbackground about file formats, example analyses, and more. Note\nthe disclaimer on package load and consult the main manuscripts\nfor further info.",
  "License": "Artistic-2.0",
  "Encoding": "UTF-8",
  "URL": "https://github.com/metamaden/recountmethylation",
  "BugReports": "https://github.com/metamaden/recountmethylation/issues",
  "VignetteBuilder": "knitr",
  "biocViews": "DNAMethylation, Epigenetics, Microarray, MethylationArray,\nExperimentHub",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:53:34 UTC",
  "RemoteUrl": "https://github.com/bioc/recountmethylation",
  "RemoteRef": "HEAD",
  "RemoteSha": "ca15d3a6cfe6ed5c8b1e6bb6558ad58d4dd52a2c",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-30 09:52:19 UTC",
    "User": "root"
  },
  "Author": "Sean K Maden [cre, aut] (ORCID:\n<https://orcid.org/0000-0002-2212-4894>),\nBrian Walsh [aut] (ORCID: <https://orcid.org/0000-0003-0913-1528>),\nKyle Ellrott [aut] (ORCID: <https://orcid.org/0000-0002-6573-5900>),\nKasper D Hansen [aut] (ORCID: <https://orcid.org/0000-0003-0086-0687>),\nReid F Thompson [aut] (ORCID: <https://orcid.org/0000-0003-3661-5296>),\nAbhinav Nellore [aut] (ORCID: <https://orcid.org/0000-0001-8145-1484>)",
  "Maintainer": "Sean K Maden <maden@ohsu.edu>",
  "MD5sum": "bf107cfa2252cf0f1302b0793423acac",
  "_user": "bioc",
  "_type": "src",
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  "_created": "2026-05-30T09:52:19.000Z",
  "_published": "2026-05-30T15:11:04.243Z",
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  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/26676618146",
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  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/recountmethylation",
  "_commit": {
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    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
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    "linkedin": "in/sean-maden-41623640",
    "orcid": "0000-0002-2212-4894",
    "twitter": "@MadenSean",
    "description": "25-11-24: See my LinkedIn. ",
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  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
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      "week": "2025-44",
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  "_topics": [
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    "epigenetics",
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  "_stars": 9,
  "_contributors": [
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    "description": "Software for the analysis and comprehension of high-throughput genomic data"
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      "topics": [
        "data_mdpost"
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    },
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      "page": "gds_idat2rg",
      "title": "Get IDATs as an RGChannelSet from GEO/GDS",
      "topics": [
        "gds_idat2rg"
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    },
    {
      "page": "gds_idatquery",
      "title": "Query and download IDATs from GEO Data Sets",
      "topics": [
        "gds_idatquery"
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    },
    {
      "page": "get_crossreactive_cpgs",
      "title": "get_crossreactive_cpgs",
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    {
      "page": "get_rmdl",
      "title": "Get DNAm assay data.",
      "topics": [
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      "topics": [
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  "_vignettes": [
    {
      "source": "recountmethylation_data_analyses.Rmd",
      "filename": "recountmethylation_data_analyses.html",
      "title": "Data Analyses",
      "author": "Sean K. Maden, Reid F. Thompson, Kasper D. Hansen, Abhinav Nellore",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Overview",
        "Analysis script and limited chunk evaluation",
        "Datasets and data objects",
        "Example 1: Comparing mined and predicted age",
        "Make new variables and filter samples",
        "Analyses and summary statistics",
        "Scatter plots of study errors and sample ages",
        "Example 2: Signal comparison of FFPE and frozen samples",
        "Get samples with storage type information",
        "Use blocking to calculate signal log2 medians",
        "Signals plotted by storage type",
        "Example 3: Identify and analyze tissue-specific probes with the highest",
        "Sample identification and summary",
        "Calculate log2 methylated and unmethylated signal medians",
        "Perform linear correction on DNAm for study IDs",
        "Perform array-wide ANOVAs and filter probes",
        "Get probe DNAm summary statistics and analyze variances",
        "Violin plots and heatmaps of probe set DNAm means and variances",
        "Conclusions",
        "Session info",
        "Works Cited"
      ],
      "created": "2020-07-13 18:32:37",
      "modified": "2023-03-27 00:20:03",
      "commits": 10
    },
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      "source": "recountmethylation_glint.Rmd",
      "filename": "recountmethylation_glint.html",
      "title": "Determine population ancestry from DNAm arrays",
      "author": "Sean K. Maden",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Obtain the GLINT software",
        "Virtual environment setup",
        "Process example DNAm array data",
        "Further reading",
        "Session Info",
        "Works Cited"
      ],
      "created": "2022-03-04 01:23:59",
      "modified": "2022-03-04 01:23:59",
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    {
      "source": "recountmethylation_search_index.Rmd",
      "filename": "recountmethylation_search_index.html",
      "title": "Nearest neighbors analysis for DNAm arrays",
      "author": "Sean K. Maden",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Background: search indexes for biological data",
        "Index samples on dimension-reduced data",
        "Virtual environment setup",
        "Perform dimensionality reduction on DNAm data",
        "Make a new HNSW search index",
        "Query nearest neighbors in the search index",
        "Get nearest neighbors from search index queries",
        "Inspect query results",
        "Plot metadata labels among nearest neighbors",
        "Metadata label frequency among neighbors from a single query",
        "Distribution of neighbors labeled whole blood across queries",
        "Distributions of multiple labels and queries",
        "Session Info",
        "Works Cited"
      ],
      "created": "2022-02-28 20:20:16",
      "modified": "2023-03-27 00:20:03",
      "commits": 5
    },
    {
      "source": "recountmethylation_pwrewas.Rmd",
      "filename": "recountmethylation_pwrewas.html",
      "title": "Power analysis for DNAm arrays",
      "author": "Sean K. Maden",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Source the revised function, pwrEWAS_itable()",
        "Generate DNAm summary statistics",
        "Run pwrEWAS_itable()",
        "Run power simulations with 2 cores",
        "Access the power analysis results",
        "Plot smooths with errors using ggplot2",
        "Next steps and further reading",
        "Session Info",
        "Works Cited"
      ],
      "created": "2022-02-28 20:20:16",
      "modified": "2022-03-04 01:21:43",
      "commits": 3
    },
    {
      "source": "cpg_probe_annotations.Rmd",
      "filename": "cpg_probe_annotations.html",
      "title": "Practical uses for provided CpG probe annotations",
      "author": "Sean K. Maden",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Probe manifest background",
        "Getting the HM450K manifest annotations from an RGChannelSet",
        "Getting the EPIC manifest annotations from an RGChannelSet",
        "Annotation-based probe filters",
        "Filtering on common SNPs",
        "Filtering on cross-reactive CpG probes",
        "Querying and quantifying genome regions and functional groups",
        "Find probes mapping to a gene",
        "Viewing gene functional region frequencies",
        "Identifying promoter-mapping and gene body-mapping CpG probes",
        "CG Island annotations",
        "Conclusions"
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