{ "_id": "6a1a0f991d7bb097a09cdcf3", "Package": "octad", "Title": "Open Cancer TherApeutic Discovery (OCTAD)", "Version": "1.15.1", "Authors@R": "c(person(given = \"E.\",\nfamily = \"Chekalin\",\nrole = c(\"aut\", \"cre\"),\nemail = \"eygen.chekalin@gmail.com\"),\nperson(given = \"S.\",\nfamily = \"Paithankar\",role =c(\"aut\")),\nperson(given = \"B.\",\nfamily = \"Zeng\",role =c(\"aut\")),\nperson(given = \"B.\",\nfamily = \"Glicksberg\",role =\"ctb\"),\nperson(given = \"P.\",\nfamily = \"Newbury\",role =\"ctb\"),\nperson(given = \"J.\",\nfamily = \"Xing\",role =\"ctb\"),\nperson(given = \"K.\",\nfamily = \"Liu\",role =\"ctb\"),\nperson(given = \"A.\",\nfamily = \"Wen\",role =\"ctb\"),\nperson(given = \"D.\",\nfamily = \"Joseph\",role =\"ctb\"),\nperson(given = \"B.\",\nfamily = \"Chen\",\nrole =\"aut\",\nemail = \"chenbi12@msu.edu\")\n)", "Description": "OCTAD provides a platform for virtually screening\ncompounds targeting precise cancer patient groups. The\nessential idea is to identify drugs that reverse the gene\nexpression signature of disease by tamping down over-expressed\ngenes and stimulating weakly expressed ones. The package offers\ndeep-learning based reference tissue selection, disease gene\nexpression signature creation, pathway enrichment analysis,\ndrug reversal potency scoring, cancer cell line selection, drug\nenrichment analysis and in silico hit validation. 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