{
  "_id": "6aabd9153d719c1f8406ff45",
  "Package": "normalize450K",
  "Type": "Package",
  "Title": "Preprocessing of Illumina Infinium 450K data",
  "Version": "1.41.0",
  "Date": "2016-11-29",
  "Author": "Jonathan Alexander Heiss",
  "Maintainer": "Jonathan Alexander Heiss <jonathan.heiss@posteo.de>",
  "Description": "Precise measurements are important for epigenome-wide\nstudies investigating DNA methylation in whole blood samples,\nwhere effect sizes are expected to be small in magnitude. The\n450K platform is often affected by batch effects and proper\npreprocessing is recommended. This package provides functions\nto read and normalize 450K '.idat' files. The normalization\ncorrects for dye bias and biases related to signal intensity\nand methylation of probes using local regression. No adjustment\nfor probe type bias is performed to avoid the trade-off of\nprecision for accuracy of beta-values.",
  "License": "BSD_2_clause + file LICENSE",
  "biocViews": "Normalization, DNAMethylation, Microarray, TwoChannel,\nPreprocessing, MethylationArray",
  "NeedsCompilation": "no",
  "Config/pak/sysreqs": "libssl-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:42:18 UTC",
  "RemoteUrl": "https://github.com/bioc/normalize450K",
  "RemoteRef": "HEAD",
  "RemoteSha": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
  "Packaged": {
    "Date": "2026-09-17 11:05:45 UTC",
    "User": "root"
  },
  "_user": "bioc",
  "_type": "src",
  "_file": "normalize450K_1.41.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/f87521dab63d9a449b4e9a41d1a609a043969f2bb01abcc870c1d33ab37a4802",
  "_filesize": 3277503,
  "_sha256": "f87521dab63d9a449b4e9a41d1a609a043969f2bb01abcc870c1d33ab37a4802",
  "_expires": "2026-12-26T12:12:02.000Z",
  "_created": "2026-09-17T11:05:45.000Z",
  "_published": "2026-09-17T12:12:04.967Z",
  "_bioccheck": {
    "error": 2,
    "warning": 3,
    "note": 15
  },
  "_host": "GitHub-Actions",
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816",
  "_status": "success",
  "_upstream": "https://github.com/bioc/normalize450K",
  "_commit": {
    "id": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777380138
  },
  "_maintainer": {
    "name": "Jonathan Alexander Heiss",
    "email": "jonathan.heiss@posteo.de"
  },
  "_distro": "resolute",
  "_jobs": [
    {
      "job": 105177757676,
      "time": 184,
      "config": "bioc-checks",
      "r": "4.6.1",
      "check": "ERROR",
      "artifact": "10493333317"
    },
    {
      "job": 105177757677,
      "time": 160,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "10493033308"
    },
    {
      "job": 105177757701,
      "time": 151,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "10494248209"
    },
    {
      "job": 105177757672,
      "time": 111,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "10496418268"
    },
    {
      "job": 105177757831,
      "time": 102,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "10496308272"
    },
    {
      "job": 105176827255,
      "time": 193,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10494042818"
    },
    {
      "job": 105177757710,
      "time": 115,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "10494302954"
    },
    {
      "job": 105177757770,
      "time": 89,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "10494132951"
    },
    {
      "job": 105177757914,
      "time": 83,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "10493138156"
    },
    {
      "job": 105177757947,
      "time": 76,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "10493003062"
    }
  ],
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.3",
      "role": "Depends"
    },
    {
      "package": "Biobase",
      "role": "Depends"
    },
    {
      "package": "illuminaio",
      "role": "Depends"
    },
    {
      "package": "quadprog",
      "role": "Depends"
    },
    {
      "package": "utils",
      "role": "Imports"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-44",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.41.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.40.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "normalization",
    "dnamethylation",
    "microarray",
    "twochannel",
    "preprocessing",
    "methylationarray"
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "followers": 467,
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 482,
    "source": "https://www.bioconductor.org/packages/stats/bioc/normalize450K"
  },
  "_searchresults": 3,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/normalize450K.html",
    "LICENSE"
  ],
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "dont_normalize450K",
    "estimateLC",
    "normalize450K",
    "read450K"
  ],
  "_help": [
    {
      "page": "estimateLC",
      "title": "Estimation of Leukocyte composition for whole blood samples",
      "topics": [
        "estimateLC"
      ]
    },
    {
      "page": "read_and_normalize450K",
      "title": "Normalization of 450K data by LOESS method",
      "topics": [
        "dont_normalize450K",
        "normalize450K",
        "read450K"
      ]
    }
  ],
  "_rundeps": [
    "askpass",
    "base64",
    "Biobase",
    "BiocGenerics",
    "generics",
    "illuminaio",
    "openssl",
    "quadprog",
    "sys"
  ],
  "_vignettes": [
    {
      "source": "read_and_normalize450K.Rnw",
      "filename": "read_and_normalize450K.pdf",
      "title": "Normalization of 450K data",
      "engine": "utils::Sweave",
      "headings": [],
      "created": "2015-12-01 22:52:06",
      "modified": "2016-04-01 09:19:21",
      "commits": 3
    }
  ],
  "_score": 3.3010299956639813,
  "_indexed": true,
  "_nocasepkg": "normalize450k",
  "_universes": [
    "bioc"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.41.0",
      "date": "2026-09-17T11:08:23.000Z",
      "distro": "resolute",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/2e7ba8cb133e4828b3fda767bdd232eea208e708298cfc0f15ca518cb2b7c2b2",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "1.41.0",
      "date": "2026-09-17T11:08:16.000Z",
      "distro": "resolute",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/c4ccbb1bc02c591385118533299461cfc3563f404ea7a80c642c9e258d103ad2",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.41.0",
      "date": "2026-09-17T12:11:06.000Z",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/9131ec37cc660460a76b8fe6ae99cfaeb88b0227f5bbbadc72cee721e995309d",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "1.41.0",
      "date": "2026-09-17T12:11:12.000Z",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/7a8ad97af55d6e129493f0a19fa3c64d7d9907830446abe29ce92d195dcc0243",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.41.0",
      "date": "2026-09-17T11:07:57.000Z",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/bc08ade3111884ca0788dccaa9cf270d5875abec45f1a5847a0bb24c5df0241e",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.41.0",
      "date": "2026-09-17T11:06:59.000Z",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/57267d08360459b3b6f832f9e83705d96e5142d3299a2d1cbd1e9fc5be121406",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.41.0",
      "date": "2026-09-17T11:07:04.000Z",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/df61a749dc41ccfad192f4cf125297c037fba2bd9720176a10e814c749ba74d6",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "1.41.0",
      "date": "2026-09-17T11:06:55.000Z",
      "commit": "b3b514ac52a07a43eed5a8fc0ef520ef98e89962",
      "fileid": "https://r2.ropensci.org/1df75b24ebbf28c2aa04c2e569d4bf1f21652c81b976a16f4cd6f6be4a477a5e",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/35213586816"
    }
  ]
}