{ "_id": "6a1ed544b401979e7340e5b0", "Package": "motifbreakR", "Title": "A Package For Predicting The Disruptiveness Of Single Nucleotide\nPolymorphisms On Transcription Factor Binding Sites", "Version": "2.27.2", "Authors@R": "c(person(given=\"Simon Gert\", family=\"Coetzee\",\nemail=\"coetzee@uthscsa.edu\", role = c(\"aut\", \"cre\"),\ncomment=c(ORCID=\"0000-0003-4267-5930\")),\nperson(given=\"Dennis J.\", family=\"Hazelett\",\nemail=\"dennis.hazelett@cshs.org\", role = c(\"aut\")))", "Description": "We introduce motifbreakR, which allows the biologist to\njudge in the first place whether the sequence surrounding the\npolymorphism is a good match, and in the second place how much\ninformation is gained or lost in one allele of the polymorphism\nrelative to another. MotifbreakR is both flexible and\nextensible over previous offerings; giving a choice of\nalgorithms for interrogation of genomes with motifs from public\nsources that users can choose from; these are 1) a weighted-sum\nprobability matrix, 2) log-probabilities, and 3) weighted by\nrelative entropy. MotifbreakR can predict effects for novel or\npreviously described variants in public databases, making it\nsuitable for tasks beyond the scope of its original design.\nLastly, it can be used to interrogate any genome curated within\nBioconductor (currently there are 32 species, a total of 109\nversions).", "VignetteBuilder": "knitr", "Encoding": "UTF-8", "License": "GPL-2", "BugReports": "https://github.com/Simon-Coetzee/motifbreakR/issues", "biocViews": "ChIPSeq, Visualization, MotifAnnotation, Transcription", "NeedsCompilation": "no", "Config/roxygen2/version": "8.0.0", "Config/pak/sysreqs": "cmake make libgsl0-dev libbz2-dev libicu-dev\nlibjpeg-dev liblzma-dev libpng-dev libuv1-dev libxml2-dev\nlibssl-dev xz-utils zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-05-20 16:29:06 UTC", "RemoteUrl": "https://github.com/bioc/motifbreakR", "RemoteRef": "HEAD", "RemoteSha": "21d39f8cc6ed7f8ef8aebedd792ffb2ebf101a6b", "Packaged": { "Date": "2026-05-20 22:02:33 UTC", "User": "root" }, "Author": "Simon Gert Coetzee [aut, cre] (ORCID:\n),\nDennis J. Hazelett [aut]", "Maintainer": "Simon Gert Coetzee ", "MD5sum": "922ad7c8fed3e10d6bc16aeb619408fd", "_user": "bioc", "_type": "src", "_file": "motifbreakR_2.27.2.tar.gz", "_fileid": "95743ca2edd295bf8b1ca122cf18bde42ffc4464c9898abf71544e62ce6a6f60", "_filesize": 2288689, "_sha256": "95743ca2edd295bf8b1ca122cf18bde42ffc4464c9898abf71544e62ce6a6f60", "_created": "2026-05-20T22:02:33.000Z", "_published": "2026-06-02T13:06:12.354Z", "_jobs": [ { "job": 79076087824, "time": 522, "config": "bioc-checks", "r": "4.6.0", "check": "WARNING", "artifact": "7122780313" }, { "job": 79076087753, "time": 950, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "ERROR", "artifact": "7122896251" }, { "job": 79076088804, "time": 882, "config": "linux-release-x86_64", "r": "4.6.0", "check": "ERROR", "artifact": "7122878302" }, { "job": 79076087259, "time": 591, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "ERROR", "artifact": "7122799618" }, { "job": 79076087532, "time": 577, "config": 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