{
  "_id": "6a1f2c36b401979e73425b43",
  "Package": "mosdef",
  "Title": "MOSt frequently used and useful Differential Expression\nFunctions",
  "Version": "1.9.0",
  "Authors@R": "c(\nperson(\ngiven = \"Leon\", family = \"Dammer\", role = c(\"aut\"),\nemail = \"lc.dammer@gmail.com\", comment = c(ORCID = \"0009-0008-4132-7639\")\n),\nperson(\ngiven = \"Federico\", family = \"Marini\", role = c(\"aut\", \"cre\"),\nemail = \"marinif@uni-mainz.de\", comment = c(ORCID = \"0000-0003-3252-7758\")\n)\n)",
  "Description": "This package provides functionality to run a number of\ntasks in the differential expression analysis workflow. This\nencompasses the most widely used steps, from running various\nenrichment analysis tools with a unified interface to creating\nplots and beautifying table components linking to external\nwebsites and databases. This streamlines the generation of\ncomprehensive analysis reports.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.3",
  "VignetteBuilder": "knitr",
  "URL": "https://github.com/imbeimainz/mosdef",
  "BugReports": "https://github.com/imbeimainz/mosdef/issues",
  "Config/testthat/edition": "3",
  "biocViews": "GeneExpression, Software, Transcription, Transcriptomics,\nDifferentialExpression, Visualization, ReportWriting,\nGeneSetEnrichment, GO",
  "Config/pak/sysreqs": "libcairo2-dev cmake libfontconfig1-dev\nlibfreetype6-dev libglpk-dev make libbz2-dev libicu-dev\nliblzma-dev libpng-dev libuv1-dev libxml2-dev libssl-dev\nxz-utils zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 13:03:03 UTC",
  "RemoteUrl": "https://github.com/bioc/mosdef",
  "RemoteRef": "HEAD",
  "RemoteSha": "be5ac3c55d564b8fa242236568a29e147a05f3f4",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-15 10:07:43 UTC",
    "User": "root"
  },
  "Author": "Leon Dammer [aut] (ORCID: <https://orcid.org/0009-0008-4132-7639>),\nFederico Marini [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-3252-7758>)",
  "Maintainer": "Federico Marini <marinif@uni-mainz.de>",
  "MD5sum": "1fc24a191177a3d8b89032ad905bddfd",
  "_user": "bioc",
  "_type": "src",
  "_file": "mosdef_1.9.0.tar.gz",
  "_fileid": "fa0a2845cb90ba707e9bdca7c6a2f8190e2a233276499b95b1db0c29d73b0bb9",
  "_filesize": 4432655,
  "_sha256": "fa0a2845cb90ba707e9bdca7c6a2f8190e2a233276499b95b1db0c29d73b0bb9",
  "_created": "2026-05-15T10:07:43.000Z",
  "_published": "2026-06-02T19:17:10.172Z",
  "_jobs": [
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      "job": 79151797356,
      "time": 326,
      "config": "bioc-checks",
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  "_bioccheck": {
    "error": 0,
    "warning": 2,
    "note": 8
  },
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/25911809325",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/mosdef",
  "_commit": {
    "id": "be5ac3c55d564b8fa242236568a29e147a05f3f4",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777381383
  },
  "_maintainer": {
    "name": "Federico Marini",
    "email": "marinif@uni-mainz.de",
    "login": "federicomarini",
    "bluesky": "@federicomarini.bsky.social",
    "linkedin": "in/federico-marini",
    "orcid": "0000-0003-3252-7758",
    "twitter": "@FedeBioinfo",
    "uuid": 7447478
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.4.0",
      "role": "Depends"
    },
    {
      "package": "DT",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "ggforce",
      "role": "Imports"
    },
    {
      "package": "ggrepel",
      "role": "Imports"
    },
    {
      "package": "graphics",
      "role": "Imports"
    },
    {
      "package": "grDevices",
      "role": "Imports"
    },
    {
      "package": "htmltools",
      "role": "Imports"
    },
    {
      "package": "methods",
      "role": "Imports"
    },
    {
      "package": "AnnotationDbi",
      "role": "Imports"
    },
    {
      "package": "topGO",
      "role": "Imports"
    },
    {
      "package": "GO.db",
      "role": "Imports"
    },
    {
      "package": "clusterProfiler",
      "role": "Imports"
    },
    {
      "package": "goseq",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "RColorBrewer",
      "role": "Imports"
    },
    {
      "package": "rlang",
      "role": "Imports"
    },
    {
      "package": "DESeq2",
      "role": "Imports"
    },
    {
      "package": "scales",
      "role": "Imports"
    },
    {
      "package": "SummarizedExperiment",
      "role": "Imports"
    },
    {
      "package": "S4Vectors",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "macrophage",
      "role": "Suggests"
    },
    {
      "package": "org.Hs.eg.db",
      "role": "Suggests"
    },
    {
      "package": "GeneTonic",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "TxDb.Hsapiens.UCSC.hg38.knownGene",
      "role": "Suggests"
    },
    {
      "package": "BiocStyle",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 4,
  "_updates": [
    {
      "week": "2025-20",
      "n": 1
    },
    {
      "week": "2025-49",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.9.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.8.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "geneexpression",
    "software",
    "transcription",
    "transcriptomics",
    "differentialexpression",
    "visualization",
    "reportwriting",
    "genesetenrichment",
    "go"
  ],
  "_stars": 0,
  "_contributors": [
    {
      "user": "ldammer",
      "count": 308,
      "uuid": 147632279
    },
    {
      "user": "federicomarini",
      "count": 207,
      "uuid": 7447478
    },
    {
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      "count": 8,
      "uuid": 1744257
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 518,
    "source": "https://www.bioconductor.org/packages/stats/bioc/mosdef"
  },
  "_devurl": "https://github.com/imbeimainz/mosdef",
  "_searchresults": 1,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/mosdef.html",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/imbeimainz/mosdef",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "buttonifier",
    "create_link_dbPTM",
    "create_link_ENSEMBL",
    "create_link_GeneCards",
    "create_link_GO",
    "create_link_GTEX",
    "create_link_HPA",
    "create_link_NCBI",
    "create_link_PubMed",
    "create_link_UniProt",
    "de_table_painter",
    "de_volcano",
    "deresult_to_df",
    "gene_plot",
    "geneinfo_to_html",
    "get_annotation_orgdb",
    "get_expr_values",
    "go_to_html",
    "go_volcano",
    "map_to_color",
    "mosdef_de_container_check",
    "mosdef_res_check",
    "pair_corr",
    "plot_ma",
    "run_cluPro",
    "run_goseq",
    "run_topGO",
    "styleColorBar_divergent"
  ],
  "_datasets": [
    {
      "name": "res_enrich_macrophage_cluPro",
      "title": "A sample enrichment object",
      "object": "res_enrich_macrophage_cluPro",
      "file": "res_enrich_macrophage_cluPro.RData",
      "class": [
        "enrichResult"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    },
    {
      "name": "res_enrich_macrophage_goseq",
      "title": "A sample enrichment object",
      "object": "res_enrich_macrophage_goseq",
      "file": "res_enrich_macrophage_goseq.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "category",
        "over_represented_pvalue",
        "under_represented_pvalue",
        "numDEInCat",
        "numInCat",
        "term",
        "ontology",
        "p.adj",
        "genes",
        "genesymbols"
      ],
      "rows": 14789,
      "table": true,
      "tojson": true
    },
    {
      "name": "res_enrich_macrophage_topGO",
      "title": "A sample enrichment object",
      "object": "res_enrich_macrophage_topGO",
      "file": "res_enrich_macrophage_topGO.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "GO.ID",
        "Term",
        "Annotated",
        "Significant",
        "Expected",
        "Rank in p.value_classic",
        "p.value_elim",
        "p.value_classic",
        "genes"
      ],
      "rows": 6116,
      "table": true,
      "tojson": true
    },
    {
      "name": "res_macrophage_IFNg_vs_naive",
      "title": "A sample 'DESeqResults' object",
      "object": "res_de_macrophage",
      "file": "res_de_macrophage.RData",
      "class": [
        "DESeqResults"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
  ],
  "_help": [
    {
      "page": "dot-info_enrichrun",
      "title": "Printing some info before the enrichment runs",
      "topics": [
        ".info_enrichrun"
      ]
    },
    {
      "page": "buttonifier",
      "title": "Create sets of buttons for gene symbols",
      "topics": [
        "buttonifier"
      ]
    },
    {
      "page": "create_link_dbPTM",
      "title": "Link to dbPTM database",
      "topics": [
        "create_link_dbPTM"
      ]
    },
    {
      "page": "create_link_ENSEMBL",
      "title": "Link to ENSEMBL database",
      "topics": [
        "create_link_ENSEMBL"
      ]
    },
    {
      "page": "create_link_genecards",
      "title": "Link to the GeneCards database",
      "topics": [
        "create_link_GeneCards"
      ]
    },
    {
      "page": "create_link_GO",
      "title": "Link to AMIGO database",
      "topics": [
        "create_link_GO"
      ]
    },
    {
      "page": "create_link_GTEX",
      "title": "Link to the GTEx Portal",
      "topics": [
        "create_link_GTEX"
      ]
    },
    {
      "page": "create_link_HPA",
      "title": "Link to the Human Protein Atlas",
      "topics": [
        "create_link_HPA"
      ]
    },
    {
      "page": "create_link_NCBI",
      "title": "Link to NCBI database",
      "topics": [
        "create_link_NCBI"
      ]
    },
    {
      "page": "create_link_pubmed",
      "title": "Link to Pubmed",
      "topics": [
        "create_link_PubMed"
      ]
    },
    {
      "page": "create_link_UniProt",
      "title": "Link to UniProt database",
      "topics": [
        "create_link_UniProt"
      ]
    },
    {
      "page": "de_table_painter",
      "title": "DE table painter",
      "topics": [
        "de_table_painter"
      ]
    },
    {
      "page": "de_volcano",
      "title": "Generates a volcano plot using ggplot2",
      "topics": [
        "de_volcano"
      ]
    },
    {
      "page": "deresult_to_df",
      "title": "Generate a table from the 'DESeq2' results",
      "topics": [
        "deresult_to_df"
      ]
    },
    {
      "page": "gene_plot",
      "title": "Plot expression values for a gene",
      "topics": [
        "gene_plot"
      ]
    },
    {
      "page": "geneinfo_to_html",
      "title": "Information on a gene",
      "topics": [
        "geneinfo_to_html"
      ]
    },
    {
      "page": "get_annotation_orgdb",
      "title": "Get an annotation data frame from org db packages",
      "topics": [
        "get_annotation_orgdb"
      ]
    },
    {
      "page": "get_expr_values",
      "title": "Get expression values",
      "topics": [
        "get_expr_values"
      ]
    },
    {
      "page": "go_to_html",
      "title": "Information on a Gene Ontology identifier",
      "topics": [
        "go_to_html"
      ]
    },
    {
      "page": "go_volcano",
      "title": "Generates a volcano plot using ggplot2 This function generates a base volcano plot highlighting genes associated with a certain GOterm that can then be expanded upon using further ggplot functions.",
      "topics": [
        "go_volcano"
      ]
    },
    {
      "page": "map_to_color",
      "title": "Maps numeric values to color values",
      "topics": [
        "map_to_color"
      ]
    },
    {
      "page": "mosdef_de_container_check",
      "title": "A function checking if your 'de_container' contains everything you need",
      "topics": [
        "mosdef_de_container_check"
      ]
    },
    {
      "page": "mosdef_res_check",
      "title": "A function checking if your res_de contains everything you need",
      "topics": [
        "mosdef_res_check"
      ]
    },
    {
      "page": "pair_corr",
      "title": "Pairwise scatter plot matrix and correlation plot of counts",
      "topics": [
        "pair_corr"
      ]
    },
    {
      "page": "plot_ma",
      "title": "MA-plot from base means and log fold changes",
      "topics": [
        "plot_ma"
      ]
    },
    {
      "page": "res_enrich_macrophage_cluPro",
      "title": "A sample enrichment object",
      "topics": [
        "res_enrich_macrophage_cluPro"
      ]
    },
    {
      "page": "res_enrich_macrophage_goseq",
      "title": "A sample enrichment object",
      "topics": [
        "res_enrich_macrophage_goseq"
      ]
    },
    {
      "page": "res_enrich_macrophage_topGO",
      "title": "A sample enrichment object",
      "topics": [
        "res_enrich_macrophage_topGO"
      ]
    },
    {
      "page": "res_macrophage_IFNg_vs_naive",
      "title": "A sample 'DESeqResults' object",
      "topics": [
        "res_macrophage_IFNg_vs_naive"
      ]
    },
    {
      "page": "run_cluPro",
      "title": "Extract functional terms enriched in the DE genes, based on clusterProfiler",
      "concept": [
        "Enrichment functions"
      ],
      "topics": [
        "run_cluPro"
      ]
    },
    {
      "page": "run_goseq",
      "title": "Extract functional terms enriched in the DE genes, based on goseq",
      "concept": [
        "Enrichment functions"
      ],
      "topics": [
        "run_goseq"
      ]
    },
    {
      "page": "run_topGO",
      "title": "Extract functional terms enriched in the DE genes, based on topGO",
      "concept": [
        "Enrichment functions"
      ],
      "topics": [
        "run_topGO"
      ]
    },
    {
      "page": "styleColorBar_divergent",
      "title": "Style DT color bars",
      "topics": [
        "styleColorBar_divergent"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/mosdef/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "aisdk",
    "AnnotationDbi",
    "ape",
    "aplot",
    "askpass",
    "base64enc",
    "BH",
    "BiasedUrn",
    "Biobase",
    "BiocBaseUtils",
    "BiocFileCache",
    "BiocGenerics",
    "BiocIO",
    "BiocParallel",
    "biomaRt",
    "Biostrings",
    "bit",
    "bit64",
    "bitops",
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    "bslib",
    "cachem",
    "callr",
    "cigarillo",
    "cli",
    "cluster",
    "clusterProfiler",
    "codetools",
    "cpp11",
    "crayon",
    "crosstalk",
    "curl",
    "DBI",
    "dbplyr",
    "DelayedArray",
    "DESeq2",
    "digest",
    "DOSE",
    "dplyr",
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    "evaluate",
    "farver",
    "fastmap",
    "filelock",
    "fontawesome",
    "fontBitstreamVera",
    "fontLiberation",
    "fontquiver",
    "formatR",
    "fs",
    "futile.logger",
    "futile.options",
    "gdtools",
    "geneLenDataBase",
    "generics",
    "GenomeInfoDb",
    "GenomicAlignments",
    "GenomicFeatures",
    "GenomicRanges",
    "ggforce",
    "ggfun",
    "ggiraph",
    "ggnewscale",
    "ggplot2",
    "ggplotify",
    "ggrepel",
    "ggtangle",
    "ggtree",
    "glue",
    "GO.db",
    "GOSemSim",
    "goseq",
    "graph",
    "gridGraphics",
    "gson",
    "gtable",
    "highr",
    "hms",
    "htmltools",
    "htmlwidgets",
    "httr",
    "httr2",
    "igraph",
    "IRanges",
    "isoband",
    "jquerylib",
    "jsonlite",
    "KEGGREST",
    "knitr",
    "labeling",
    "lambda.r",
    "later",
    "lattice",
    "lazyeval",
    "lifecycle",
    "locfit",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixGenerics",
    "matrixStats",
    "memoise",
    "mgcv",
    "mime",
    "nlme",
    "openssl",
    "otel",
    "patchwork",
    "pillar",
    "pkgconfig",
    "plyr",
    "png",
    "polyclip",
    "prettyunits",
    "processx",
    "progress",
    "promises",
    "ps",
    "purrr",
    "qvalue",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "RCurl",
    "reshape2",
    "restfulr",
    "Rhtslib",
    "rjson",
    "rlang",
    "rmarkdown",
    "Rsamtools",
    "RSQLite",
    "rtracklayer",
    "S4Arrays",
    "S4Vectors",
    "S7",
    "sass",
    "scales",
    "scatterpie",
    "Seqinfo",
    "snow",
    "SparseArray",
    "SparseM",
    "stringi",
    "stringr",
    "SummarizedExperiment",
    "sys",
    "systemfonts",
    "tibble",
    "tidydr",
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      "source": "mosdef_userguide.Rmd",
      "filename": "mosdef_userguide.html",
      "title": "The mosdef User's Guide",
      "author": "Leon Dammer, Federico Marini",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Required input",
        "Demonstrating mosdef on the macrophage data",
        "Installation",
        "Getting started",
        "Load the data",
        "Generating enrichment results with a unified API",
        "mosdef and topGO",
        "mosdef and goseq",
        "mosdef and clusterProfiler",
        "Alternative ways to run enrichment analyses, within mosdef",
        "Plotting expression values in the context of DE",
        "Individual genes - gene_plot()",
        "All genes at once - Volcano plots",
        "All genes at once - MA plots",
        "Beautifying and enhancing analysis reports",
        "More information on features/genes",
        "More information on GO terms",
        "Session Info",
        "References"
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      "created": "2021-10-01 09:33:29",
      "modified": "2024-09-13 13:51:15",
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