{ "_id": "6a1fe3e0b401979e7343ba74", "Package": "mitch", "Title": "Multi-Contrast Gene Set Enrichment Analysis", "Version": "1.25.0", "Authors@R": "c(\nperson(given = \"Mark\",\nfamily = \"Ziemann\",\nrole = c(\"aut\",\"cre\",\"cph\"),\nemail = \"mark.ziemann@gmail.com\",\ncomment = c(ORCID=\"0000-0002-7688-6974\")),\nperson(given=\"Antony\",\nfamily=\"Kaspi\",\nrole = c(\"aut\",\"cph\"))\n)", "Description": "mitch is an R package for multi-contrast enrichment\nanalysis. At it’s heart, it uses a rank-MANOVA based\nstatistical approach to detect sets of genes that exhibit\nenrichment in the multidimensional space as compared to the\nbackground. The rank-MANOVA concept dates to work by Cox and\nMann (https://doi.org/10.1186/1471-2105-13-S16-S12). mitch is\nuseful for pathway analysis of profiling studies with one, two\nor more contrasts, or in studies with multiple omics profiling,\nfor example proteomic, transcriptomic, epigenomic analysis of\nthe same samples. mitch is perfectly suited for pathway level\ndifferential analysis of scRNA-seq data. We have an established\nroutine for pathway enrichment of Infinium Methylation Array\ndata (see vignette). The main strengths of mitch are that it\ncan import datasets easily from many upstream tools and has\nadvanced plotting features to visualise these enrichments.", "License": "CC BY-SA 4.0 + file LICENSE", "Encoding": "UTF-8", "URL": "https://github.com/markziemann/mitch", "BugReports": "https://github.com/markziemann/mitch", "LazyData": "false", "RoxygenNote": "7.3.2", "biocViews": "GeneExpression, GeneSetEnrichment, SingleCell,\nTranscriptomics, Epigenetics, Proteomics,\nDifferentialExpression, Reactome, DNAMethylation,\nMethylationArray, DataImport", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "cmake libfontconfig1-dev libfreetype6-dev\nlibfribidi-dev make libharfbuzz-dev libicu-dev libpng-dev\nlibuv1-dev libxml2-dev libssl-dev zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:51:28 UTC", "RemoteUrl": "https://github.com/bioc/mitch", "RemoteRef": "HEAD", "RemoteSha": "c194df123d058e019f8102e9fe2143f9ad2c572c", "NeedsCompilation": "no", 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